PubTransformer

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PMID- 28403838
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170420
LR  - 20170420
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Apr 12
TI  - A Dalbergia odorifera extract improves the survival of endotoxemia model mice by 
      inhibiting HMGB1 release.
PG  - 212
LID - 10.1186/s12906-017-1725-0 [doi]
AB  - BACKGROUND: Dalbergia odorifera T. Chen (Leguminosae) is an indigenous medicinal 
      herb that is widely used as a popular remedy in northern and eastern Asia.
      However, the cellular mechanisms underlying the biological activity of D.
      odorifera are not fully elucidated. METHODS: Anti-inflammatory effect of D.
      odorifera extract (DOE) was determined through intraperitoneal injection in a
      mouse model of endotoxemia induced by lipopolysaccharide (LPS). RAW 264.7 cells, 
      a murine macrophage, were also treated with LPS to generate a cellular model of
      inflammation, and investigated the anti-inflammatory activity and underlying
      mechanisms of DOE and its constituent isoliquiritigenin. RESULTS: DOE
      dose-dependently inhibited LPS-induced release of high mobility group box 1
      (HMGB1), a late proinflammatory cytokine, and decreased cytosolic translocation
      of HMGB1 in RAW264.7 cells. This inhibitory effect of DOE on HMGB1 release was
      observed in cells treated with DOE before or after LPS treatment, suggesting that
      DOE is effective for both treatment and prevention. In addition, DOE
      significantly inhibited LPS-induced formation of nitric oxide (NO) and expression
      of inducible NO synthase (iNOS) in a dose-dependent manner. These effects of DOE 
      were accompanied by suppression of HMGB1 release triggered by LPS, suggesting a
      possible mechanism by which DOE modulates HMGB1 release through NO signaling.
      Isoriquiritigenin, a constituent of DOE, also attenuated LPS-triggered NO
      formation and HMGB1 release in RAW264.7 cells, indicating that isoriquiritigenin 
      is an indexing molecule for the anti-inflammatory properties of DOE. Furthermore,
      c-Jun N-terminal kinase, but not extracellular signal-regulated kinase and p38,
      mediated DOE-dependent inhibition of HMGB1 release and NO/iNOS induction in RAW
      264.7 cells exposed to LPS. Notably, administration of DOE ameliorated survival
      rates in a mouse model of endotoxemia induced by LPS, where decreased level of
      circulating HMGB1 was observed. CONCLUSION: These results suggest that DOE
      confers resistance to LPS-triggered inflammation through NO-mediated inhibitory
      effects on HMGB1 release.
FAU - Choi, Hyuk Soo
AU  - Choi HS
AD  - College of Animal Bioscience & Technology, Konkuk University, 120 Neungdong-ro,
      Gwangjin-gu, Seoul, 05029, Korea.
FAU - Park, Jin-A
AU  - Park JA
AD  - Department of Veternary Pharmacology and Toxicology, College of Veterinary
      Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea.
FAU - Hwang, Jung Seok
AU  - Hwang JS
AD  - College of Animal Bioscience & Technology, Konkuk University, 120 Neungdong-ro,
      Gwangjin-gu, Seoul, 05029, Korea.
FAU - Ham, Sun Ah
AU  - Ham SA
AD  - College of Animal Bioscience & Technology, Konkuk University, 120 Neungdong-ro,
      Gwangjin-gu, Seoul, 05029, Korea.
FAU - Yoo, Taesik
AU  - Yoo T
AD  - College of Animal Bioscience & Technology, Konkuk University, 120 Neungdong-ro,
      Gwangjin-gu, Seoul, 05029, Korea.
FAU - Lee, Won Jin
AU  - Lee WJ
AD  - College of Animal Bioscience & Technology, Konkuk University, 120 Neungdong-ro,
      Gwangjin-gu, Seoul, 05029, Korea.
FAU - Paek, Kyung Shin
AU  - Paek KS
AD  - Department of Nursing, Semyung University, Semyung-ro, Jechon, Chungbuk, 390-711,
      Korea.
FAU - Shin, Ho-Chul
AU  - Shin HC
AD  - Department of Veternary Pharmacology and Toxicology, College of Veterinary
      Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea.
FAU - Lee, Chi-Ho
AU  - Lee CH
AD  - College of Animal Bioscience & Technology, Konkuk University, 120 Neungdong-ro,
      Gwangjin-gu, Seoul, 05029, Korea.
FAU - Seo, Han Geuk
AU  - Seo HG
AD  - College of Animal Bioscience & Technology, Konkuk University, 120 Neungdong-ro,
      Gwangjin-gu, Seoul, 05029, Korea. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170412
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/isolation & purification/*therapeutic use
MH  - Dalbergia/*chemistry
MH  - Disease Models, Animal
MH  - Endotoxemia/chemically induced/*drug therapy
MH  - HMGB1 Protein/*antagonists & inhibitors
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - Lipopolysaccharides
MH  - Macrophages/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nitric Oxide/metabolism
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - RAW 264.7 Cells
MH  - Signal Transduction/drug effects
PMC - PMC5389052
OTO - NOTNLM
OT  - Dalbergia Odorifera
OT  - Endotoxemia
OT  - HMGB1
OT  - Inflammation
OT  - Nitric oxide
EDAT- 2017/04/14 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/14 06:00
PHST- 2016/09/01 [received]
PHST- 2017/04/05 [accepted]
AID - 10.1186/s12906-017-1725-0 [doi]
AID - 10.1186/s12906-017-1725-0 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Apr 12;17(1):212. doi: 10.1186/s12906-017-1725-0.

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