PubTransformer

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PMID- 28403936
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170419
LR  - 20170419
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 70
DP  - 2017 May
TI  - The short-term and long-term effects of bariatric/metabolic surgery on
      subcutaneous adipose tissue inflammation in humans.
PG  - 12-22
LID - S0026-0495(17)30043-4 [pii]
LID - 10.1016/j.metabol.2017.01.030 [doi]
AB  - CONTEXT: The mechanisms mediating the short- and long-term improvements in
      glucose homeostasis following bariatric/metabolic surgery remain incompletely
      understood. OBJECTIVE: To investigate whether a reduction in adipose tissue
      inflammation plays a role in the metabolic improvements seen after
      bariatric/metabolic surgery, both in the short-term and longer-term. DESIGN:
      Fasting blood and subcutaneous abdominal adipose tissue were obtained before
      (n=14), at one month (n=9), and 6-12months (n=14) after bariatric/metabolic
      surgery from individuals with obesity who were not on insulin or anti-diabetes
      medication. Adipose tissue inflammation was assessed by a combination of
      whole-tissue gene expression and flow cytometry-based quantification of tissue
      leukocytes. RESULTS: One month after surgery, body weight was reduced by
      13.5+/-4.4kg (p<0.001), with improvements in glucose tolerance reflected by a
      decrease in area-under-the-curve (AUC) glucose in 3-h oral glucose tolerance
      tests (-105+/-98mmol/L * min; p=0.009) and enhanced pancreatic beta-cell function
      (insulinogenic index: +0.8+/-0.9pmol/mmol; p=0.032), but no change in estimated
      insulin sensitivity (Matsuda insulin sensitivity index [ISI]; p=0.720).
      Furthermore, although biomarkers of systemic inflammation and pro-inflammatory
      gene expression in adipose tissue remained unchanged, the number of neutrophils
      increased in adipose tissue 15-20 fold (p<0.001), with less substantial increases
      in other leukocyte populations. By the 6-12month follow-up visit, body weight was
      reduced by 34.8+/-10.8kg (p<0.001) relative to baseline, and glucose tolerance
      was further improved (AUC glucose -276+/-229; p<0.001) along with estimated
      insulin sensitivity (Matsuda ISI: +4.6+/-3.2; p<0.001). In addition, improvements
      in systemic inflammation were reflected by reductions in circulating C-reactive
      protein (CRP; -2.0+/-5.3mg/dL; p=0.002), and increased serum adiponectin
      (+1358+/-1406pg/mL; p=0.003). However, leukocyte infiltration of adipose tissue
      remained elevated relative to baseline, with pro-inflammatory cytokine mRNA
      expression unchanged, while adiponectin mRNA expression trended downward
      (p=0.069). CONCLUSION: Both the short- and longer-term metabolic improvements
      following bariatric/metabolic surgery occur without significant reductions in
      measures of adipose tissue inflammation, as assessed by measuring the expression 
      of genes encoding key mediators of inflammation and by flow cytometric
      immunophenotyping and quantification of adipose tissue leukocytes.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Hagman, Derek K
AU  - Hagman DK
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, WA 98109, USA; Diabetes Research Center, University of Washington,
      Seattle, WA 98195, USA.
FAU - Larson, Ilona
AU  - Larson I
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, WA 98109, USA.
FAU - Kuzma, Jessica N
AU  - Kuzma JN
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, WA 98109, USA.
FAU - Cromer, Gail
AU  - Cromer G
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, WA 98109, USA.
FAU - Makar, Karen
AU  - Makar K
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, WA 98109, USA.
FAU - Rubinow, Katya B
AU  - Rubinow KB
AD  - Department of Medicine, Division of Metabolism, Endocrinology & Nutrition,
      University of Washington, Seattle, WA 98195, USA.
FAU - Foster-Schubert, Karen E
AU  - Foster-Schubert KE
AD  - Department of Medicine, Division of Metabolism, Endocrinology & Nutrition,
      University of Washington, Seattle, WA 98195, USA.
FAU - van Yserloo, Brian
AU  - van Yserloo B
AD  - Department of Surgery, University of Washington, Seattle, WA 98195, USA.
FAU - Billing, Peter S
AU  - Billing PS
AD  - Puget Sound Surgical Center, Edmonds, WA 98026, USA.
FAU - Landerholm, Robert W
AU  - Landerholm RW
AD  - Puget Sound Surgical Center, Edmonds, WA 98026, USA.
FAU - Crouthamel, Matthew
AU  - Crouthamel M
AD  - Puget Sound Surgical Center, Edmonds, WA 98026, USA.
FAU - Flum, David R
AU  - Flum DR
AD  - Department of Surgery, University of Washington, Seattle, WA 98195, USA;
      Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.
FAU - Cummings, David E
AU  - Cummings DE
AD  - Department of Medicine, Division of Metabolism, Endocrinology & Nutrition,
      University of Washington, Seattle, WA 98195, USA.
FAU - Kratz, Mario
AU  - Kratz M
AD  - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
      Seattle, WA 98109, USA; Department of Medicine, Division of Metabolism,
      Endocrinology & Nutrition, University of Washington, Seattle, WA 98195, USA;
      Department of Epidemiology, University of Washington, Seattle, WA 98195, USA;
      Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.
      Electronic address: [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170202
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
SB  - IM
MH  - Bariatric Surgery/*methods
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Immunophenotyping
MH  - Inflammation/*surgery
MH  - Insulin Resistance
MH  - Leukocyte Count
MH  - Male
MH  - Metabolism
MH  - Subcutaneous Fat/*pathology/surgery
MH  - Time Factors
MH  - Weight Loss
OTO - NOTNLM
OT  - Adipose tissue inflammation
OT  - Bariatric surgery
OT  - Insulin resistance
OT  - Metabolic surgery
EDAT- 2017/04/14 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/14 06:00
PHST- 2016/09/23 [received]
PHST- 2017/01/25 [revised]
PHST- 2017/01/28 [accepted]
AID - S0026-0495(17)30043-4 [pii]
AID - 10.1016/j.metabol.2017.01.030 [doi]
PST - ppublish
SO  - Metabolism. 2017 May;70:12-22. doi: 10.1016/j.metabol.2017.01.030. Epub 2017 Feb 
      2.

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