Shape of the OGTT glucose curve and risk of impaired glucose metabolism in the EGIR-RISC cohort.
|Abstract||To study whether the shape of the oral glucose tolerance test (OGTT)-glucose curve is a stable trait over time; it is associated with differences in insulin sensitivity, ß-cell function and risk of impaired fasting glucose (IFG) and glucose tolerance (IGT) in the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) cohort.|
Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired β-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study.
|Journal Title||metabolism: clinical and experimental|
|Publication Year Start||2017-01-01|
PMID- 28403944 OWN - NLM STAT- MEDLINE DA - 20170413 DCOM- 20170419 LR - 20170419 IS - 1532-8600 (Electronic) IS - 0026-0495 (Linking) VI - 70 DP - 2017 May TI - Shape of the OGTT glucose curve and risk of impaired glucose metabolism in the EGIR-RISC cohort. PG - 42-50 LID - S0026-0495(17)30054-9 [pii] LID - 10.1016/j.metabol.2017.02.007 [doi] AB - OBJECTIVE: To study whether the shape of the oral glucose tolerance test (OGTT)-glucose curve is a stable trait over time; it is associated with differences in insulin sensitivity, ss-cell function and risk of impaired fasting glucose (IFG) and glucose tolerance (IGT) in the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) cohort. METHODS: OGTT-glucose curve shape was classified as monophasic, biphasic, triphasic and anomalous in 915 individuals. Oral glucose insulin sensitivity (OGIS), Matsuda insulin sensitivity index (ISI) and ss-cell function were assessed at baseline and 3years apart. RESULTS: The OGTT-glucose curve had the same baseline shape after 3years in 540 people (59%; kappa=0.115; p<0.0001). Seventy percent of the participants presented with monophasic OGTT-glucose curve shape at baseline and after 3years (percent positive agreement 0.74). Baseline monophasic shape was associated with significant increased risk of IFG (OR 1.514; 95% CI 1.084-2.116; p=0.015); biphasic shape with reduced risk of IGT (OR 0.539; 95% CI 0.310-0.936) and triphasic shape with reduced risk of IFG (OR 0.493; 95% CI 0.228-1.066; P=0.043) after 3years. Increased risks of IFG (OR 1.509; 95% CI 1.008-2.260; p=0.05) and IGT (OR 1.947; 95% CI 1.085-3.494; p=0.02) were found in people who kept stable monophasic morphology over time and in switchers from biphasic to monophasic shape (OR of IGT=3.085; 95% CI 1.377-6.912; p=0.001). CONCLUSION: After 3years follow-up, the OGTT-glucose shape was stable in 59% of the RISC cohort. Shapes were associated with different OGIS and ss-cell function; persistence over time of the monophasic shape and switch from biphasic to monophasic shape with increased risk of impaired glucose metabolism. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Manco, Melania AU - Manco M AD - Bambino Gesu` Children's Hospital, IRCCS, Research Unit for Multi-factorial Diseases, Obesity and Diabetes, Rome, Italy. Electronic address: [email protected] FAU - Nolfe, Giuseppe AU - Nolfe G AD - Institute of Applied Science and Intelligent Systems "E. Caianiello" (ISASI), National Research Council of Italy-CNR, Pozzuoli, Italy. Electronic address: [email protected] FAU - Pataky, Zoltan AU - Pataky Z AD - Medecin-adjointe agree, Departement de medecine communautaire et de premier recours; Hopitaux Universitaires de Geneve, Switzerland. Electronic address: [email protected] FAU - Monti, Lucilla AU - Monti L AD - Unita di Malattie Metaboliche Medicina 1, Istituto Scientifico San Raffaele, Milan, Italy.. Electronic address: [email protected] FAU - Porcellati, Francesca AU - Porcellati F AD - DiMI, University of Perugia, Italy. Electronic address: [email protected] FAU - Gabriel, Rafael AU - Gabriel R AD - Instituto de Salud Carlos III., Madrid, Spain. Electronic address: [email protected] FAU - Mitrakou, Asimina AU - Mitrakou A AD - Department of Clinical Therapeutics, Athens University Medical School, Athens, Greece. Electronic address: [email protected] FAU - Mingrone, Geltrude AU - Mingrone G AD - Department of Internal Medicine, Catholic University, School of Medicine, Rome, Italy. Electronic address: [email protected] LA - eng PT - Journal Article PT - Observational Study DEP - 20170214 PL - United States TA - Metabolism JT - Metabolism: clinical and experimental JID - 0375267 RN - 0 (Blood Glucose) SB - IM MH - Adult MH - Blood Glucose/metabolism MH - Cardiovascular Diseases/*metabolism MH - Cardiovascular System MH - Cohort Studies MH - Female MH - Follow-Up Studies MH - Glucose Intolerance/diagnosis/*metabolism MH - *Glucose Tolerance Test MH - Humans MH - Insulin Resistance MH - Insulin-Secreting Cells MH - Male MH - Middle Aged MH - Prospective Studies MH - Risk OTO - NOTNLM OT - *Glucose curve shape OT - *Glucose tolerance OT - *Insulin secretion OT - *Insulin sensitivity OT - *Oral glucose tolerance test EDAT- 2017/04/14 06:00 MHDA- 2017/04/20 06:00 CRDT- 2017/04/14 06:00 PHST- 2016/11/18 [received] PHST- 2017/01/27 [revised] PHST- 2017/02/04 [accepted] AID - S0026-0495(17)30054-9 [pii] AID - 10.1016/j.metabol.2017.02.007 [doi] PST - ppublish SO - Metabolism. 2017 May;70:42-50. doi: 10.1016/j.metabol.2017.02.007. Epub 2017 Feb 14.
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