PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Shape of the OGTT glucose curve and risk of impaired glucose metabolism in the EGIR-RISC cohort.

Abstract To study whether the shape of the oral glucose tolerance test (OGTT)-glucose curve is a stable trait over time; it is associated with differences in insulin sensitivity, ß-cell function and risk of impaired fasting glucose (IFG) and glucose tolerance (IGT) in the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) cohort.
PMID
Related Publications

Shape of glucose, insulin, C-peptide curves during a 3-h oral glucose tolerance test: any relationship with the degree of glucose tolerance?

Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired β-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study.

Assessing the shape of the glucose curve during an oral glucose tolerance test.

Beta-cell function and insulin sensitivity contribute to the shape of plasma glucose curve during an oral glucose tolerance test in non-diabetic individuals.

Impaired early- but not late-phase insulin secretion in subjects with impaired fasting glucose.

Authors

Mayor MeshTerms

Glucose Tolerance Test

Keywords

Glucose curve shape

Glucose tolerance

Insulin secretion

Insulin sensitivity

Oral glucose tolerance test

Journal Title metabolism: clinical and experimental
Publication Year Start




PMID- 28403944
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170419
LR  - 20170419
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 70
DP  - 2017 May
TI  - Shape of the OGTT glucose curve and risk of impaired glucose metabolism in the
      EGIR-RISC cohort.
PG  - 42-50
LID - S0026-0495(17)30054-9 [pii]
LID - 10.1016/j.metabol.2017.02.007 [doi]
AB  - OBJECTIVE: To study whether the shape of the oral glucose tolerance test
      (OGTT)-glucose curve is a stable trait over time; it is associated with
      differences in insulin sensitivity, ss-cell function and risk of impaired fasting
      glucose (IFG) and glucose tolerance (IGT) in the Relationship between Insulin
      Sensitivity and Cardiovascular Disease (RISC) cohort. METHODS: OGTT-glucose curve
      shape was classified as monophasic, biphasic, triphasic and anomalous in 915
      individuals. Oral glucose insulin sensitivity (OGIS), Matsuda insulin sensitivity
      index (ISI) and ss-cell function were assessed at baseline and 3years apart.
      RESULTS: The OGTT-glucose curve had the same baseline shape after 3years in 540
      people (59%; kappa=0.115; p<0.0001). Seventy percent of the participants
      presented with monophasic OGTT-glucose curve shape at baseline and after 3years
      (percent positive agreement 0.74). Baseline monophasic shape was associated with 
      significant increased risk of IFG (OR 1.514; 95% CI 1.084-2.116; p=0.015);
      biphasic shape with reduced risk of IGT (OR 0.539; 95% CI 0.310-0.936) and
      triphasic shape with reduced risk of IFG (OR 0.493; 95% CI 0.228-1.066; P=0.043) 
      after 3years. Increased risks of IFG (OR 1.509; 95% CI 1.008-2.260; p=0.05) and
      IGT (OR 1.947; 95% CI 1.085-3.494; p=0.02) were found in people who kept stable
      monophasic morphology over time and in switchers from biphasic to monophasic
      shape (OR of IGT=3.085; 95% CI 1.377-6.912; p=0.001). CONCLUSION: After 3years
      follow-up, the OGTT-glucose shape was stable in 59% of the RISC cohort. Shapes
      were associated with different OGIS and ss-cell function; persistence over time
      of the monophasic shape and switch from biphasic to monophasic shape with
      increased risk of impaired glucose metabolism.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Manco, Melania
AU  - Manco M
AD  - Bambino Gesu` Children's Hospital, IRCCS, Research Unit for Multi-factorial
      Diseases, Obesity and Diabetes, Rome, Italy. Electronic address:
      [email protected]
FAU - Nolfe, Giuseppe
AU  - Nolfe G
AD  - Institute of Applied Science and Intelligent Systems "E. Caianiello" (ISASI),
      National Research Council of Italy-CNR, Pozzuoli, Italy. Electronic address:
      [email protected]
FAU - Pataky, Zoltan
AU  - Pataky Z
AD  - Medecin-adjointe agree, Departement de medecine communautaire et de premier
      recours; Hopitaux Universitaires de Geneve, Switzerland. Electronic address:
      [email protected]
FAU - Monti, Lucilla
AU  - Monti L
AD  - Unita di Malattie Metaboliche Medicina 1, Istituto Scientifico San Raffaele,
      Milan, Italy.. Electronic address: [email protected]
FAU - Porcellati, Francesca
AU  - Porcellati F
AD  - DiMI, University of Perugia, Italy. Electronic address: [email protected]
FAU - Gabriel, Rafael
AU  - Gabriel R
AD  - Instituto de Salud Carlos III., Madrid, Spain. Electronic address:
      [email protected]
FAU - Mitrakou, Asimina
AU  - Mitrakou A
AD  - Department of Clinical Therapeutics, Athens University Medical School, Athens,
      Greece. Electronic address: [email protected]
FAU - Mingrone, Geltrude
AU  - Mingrone G
AD  - Department of Internal Medicine, Catholic University, School of Medicine, Rome,
      Italy. Electronic address: [email protected]
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170214
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/*metabolism
MH  - Cardiovascular System
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/diagnosis/*metabolism
MH  - *Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk
OTO - NOTNLM
OT  - *Glucose curve shape
OT  - *Glucose tolerance
OT  - *Insulin secretion
OT  - *Insulin sensitivity
OT  - *Oral glucose tolerance test
EDAT- 2017/04/14 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/14 06:00
PHST- 2016/11/18 [received]
PHST- 2017/01/27 [revised]
PHST- 2017/02/04 [accepted]
AID - S0026-0495(17)30054-9 [pii]
AID - 10.1016/j.metabol.2017.02.007 [doi]
PST - ppublish
SO  - Metabolism. 2017 May;70:42-50. doi: 10.1016/j.metabol.2017.02.007. Epub 2017 Feb 
      14.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>