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Vitamin K and osteoporosis: Myth or reality?

Abstract Vitamin K is a liposoluble vitamin. The predominant dietary form, phylloquinone or vitamin K1, is found in plants and green vegetables; whereas menaquinone, or vitamin K2, is endogenously synthesized by intestinal bacteria and includes several subtypes that differ in side chain length. Aside from its established role in blood clotting, several studies now support a critical function of vitamin K in improving bone health. Vitamin K is in fact required for osteocalcin carboxylation that in turn regulates bone mineral accretion; it seems to promote the transition of osteoblasts to osteocytes and also limits the process of osteoclastogenesis. Several observational and interventional studies have examined the relationship between vitamin K and bone metabolism, but findings are conflicting and unclear. This systematic review aims to investigate the impact of vitamin K (plasma levels, dietary intake, and oral supplementation) on bone health with a particular interest in bone remodeling, mineral density and fragility fractures.
PMID
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Authors

Mayor MeshTerms
Keywords

BMD

Fracture

Osteoporosis

Vitamin K1

Vitamin K2

Journal Title metabolism: clinical and experimental
Publication Year Start




PMID- 28403946
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170419
LR  - 20170419
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 70
DP  - 2017 May
TI  - Vitamin K and osteoporosis: Myth or reality?
PG  - 57-71
LID - S0026-0495(17)30045-8 [pii]
LID - 10.1016/j.metabol.2017.01.032 [doi]
AB  - Vitamin K is a liposoluble vitamin. The predominant dietary form, phylloquinone
      or vitamin K1, is found in plants and green vegetables; whereas menaquinone, or
      vitamin K2, is endogenously synthesized by intestinal bacteria and includes
      several subtypes that differ in side chain length. Aside from its established
      role in blood clotting, several studies now support a critical function of
      vitamin K in improving bone health. Vitamin K is in fact required for osteocalcin
      carboxylation that in turn regulates bone mineral accretion; it seems to promote 
      the transition of osteoblasts to osteocytes and also limits the process of
      osteoclastogenesis. Several observational and interventional studies have
      examined the relationship between vitamin K and bone metabolism, but findings are
      conflicting and unclear. This systematic review aims to investigate the impact of
      vitamin K (plasma levels, dietary intake, and oral supplementation) on bone
      health with a particular interest in bone remodeling, mineral density and
      fragility fractures.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Palermo, Andrea
AU  - Palermo A
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy.
FAU - Tuccinardi, Dario
AU  - Tuccinardi D
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy. Electronic address: [email protected]
FAU - D'Onofrio, Luca
AU  - D'Onofrio L
AD  - Department of Experimental Medicine, Polo Pontino, Sapienza University of Rome,
      00185 Rome, Italy.
FAU - Watanabe, Mikiko
AU  - Watanabe M
AD  - Department of Experimental Medicine, Section of Medical Physiopathology and
      Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
FAU - Maggi, Daria
AU  - Maggi D
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy.
FAU - Maurizi, Anna Rita
AU  - Maurizi AR
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy.
FAU - Greto, Valentina
AU  - Greto V
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy.
FAU - Buzzetti, Raffaella
AU  - Buzzetti R
AD  - Department of Experimental Medicine, Polo Pontino, Sapienza University of Rome,
      00185 Rome, Italy.
FAU - Napoli, Nicola
AU  - Napoli N
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy.
FAU - Pozzilli, Paolo
AU  - Pozzilli P
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy.
FAU - Manfrini, Silvia
AU  - Manfrini S
AD  - Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome,
      00128 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170204
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 12001-79-5 (Vitamin K)
SB  - IM
MH  - Aged
MH  - Bone and Bones/metabolism
MH  - Female
MH  - Fractures, Bone
MH  - Humans
MH  - Male
MH  - Nutrition Assessment
MH  - Osteoporosis/*etiology
MH  - Vitamin K/pharmacology/*physiology
OTO - NOTNLM
OT  - BMD
OT  - Fracture
OT  - Osteoporosis
OT  - Vitamin K1
OT  - Vitamin K2
EDAT- 2017/04/14 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/14 06:00
PHST- 2016/06/13 [received]
PHST- 2017/01/26 [revised]
PHST- 2017/01/28 [accepted]
AID - S0026-0495(17)30045-8 [pii]
AID - 10.1016/j.metabol.2017.01.032 [doi]
PST - ppublish
SO  - Metabolism. 2017 May;70:57-71. doi: 10.1016/j.metabol.2017.01.032. Epub 2017 Feb 
      4.

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