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Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes.

Abstract The objective of this study is to find single nucleotide polymorphisms (SNPs) associated with a risk of Type 2 diabetes (T2D) in Korean adults and to investigate the longitudinal association between these SNPs and T2D and the interaction effects of iron intake and average hemoglobin level. Data from the KoGES_Ansan and Ansung Study were used. Gene-iron interaction analysis was conducted using a two-step approach. To select candidate SNPs associated with T2D, a total of 7,935 adults at baseline were included in genome-wide association analysis (step one). After excluding T2D prevalent cases, prospective analyses were conducted with 7,024 adults aged 40-69 (step two). The association of selected SNPs and iron status with T2D and their interaction were determined using a Cox proportional hazard model. A total of 3 SNPs [rs9465871 (CDKAL1), rs10761745 (JMJD1C), and rs163177 (KCNQ1)] were selected as candidate SNPs related to T2D. Among them, rs10761745 (JMJD1C) and rs163177 (KCNQ1) were prospectively associated with T2D. High iron intake was also prospectively associated with the risk of T2D after adjusting for covariates. Average hemoglobin level was positively associated with T2D after adjusting for covariates in women. We also found significant interaction effects between rs10761745 (JMJD1C) and average hemoglobin levels on the risk of T2D among women with normal inflammation and without anemia at baseline. In conclusion, KCNQ1 and JMJD1C may prospectively contribute to the risk of T2D incidence among adults over the age of 40 and JMJD1C, but CDKAL1 may not, and iron status may interactively contribute to T2D incidence in women.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title plos one
Publication Year Start




PMID- 28406950
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170420
LR  - 20170420
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Interaction of iron status with single nucleotide polymorphisms on incidence of
      type 2 diabetes.
PG  - e0175681
LID - 10.1371/journal.pone.0175681 [doi]
AB  - The objective of this study is to find single nucleotide polymorphisms (SNPs)
      associated with a risk of Type 2 diabetes (T2D) in Korean adults and to
      investigate the longitudinal association between these SNPs and T2D and the
      interaction effects of iron intake and average hemoglobin level. Data from the
      KoGES_Ansan and Ansung Study were used. Gene-iron interaction analysis was
      conducted using a two-step approach. To select candidate SNPs associated with
      T2D, a total of 7,935 adults at baseline were included in genome-wide association
      analysis (step one). After excluding T2D prevalent cases, prospective analyses
      were conducted with 7,024 adults aged 40-69 (step two). The association of
      selected SNPs and iron status with T2D and their interaction were determined
      using a Cox proportional hazard model. A total of 3 SNPs [rs9465871 (CDKAL1),
      rs10761745 (JMJD1C), and rs163177 (KCNQ1)] were selected as candidate SNPs
      related to T2D. Among them, rs10761745 (JMJD1C) and rs163177 (KCNQ1) were
      prospectively associated with T2D. High iron intake was also prospectively
      associated with the risk of T2D after adjusting for covariates. Average
      hemoglobin level was positively associated with T2D after adjusting for
      covariates in women. We also found significant interaction effects between
      rs10761745 (JMJD1C) and average hemoglobin levels on the risk of T2D among women 
      with normal inflammation and without anemia at baseline. In conclusion, KCNQ1 and
      JMJD1C may prospectively contribute to the risk of T2D incidence among adults
      over the age of 40 and JMJD1C, but CDKAL1 may not, and iron status may
      interactively contribute to T2D incidence in women.
FAU - Kim, Jihye
AU  - Kim J
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University,
      Seoul, South Korea.
AD  - Institute for Health and Society, Hanyang University, Seoul, South Korea.
FAU - Kim, Mi Kyung
AU  - Kim MK
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University,
      Seoul, South Korea.
AD  - Institute for Health and Society, Hanyang University, Seoul, South Korea.
FAU - Jung, Sukyoung
AU  - Jung S
AD  - Department of Preventive Medicine, College of Medicine, Hanyang University,
      Seoul, South Korea.
AD  - Institute for Health and Society, Hanyang University, Seoul, South Korea.
FAU - Lim, Ji Eun
AU  - Lim JE
AD  - Department of Biomedical Engineering, School of Medicine, Kyung Hee University,
      Seoul, South Korea.
FAU - Shin, Myung-Hee
AU  - Shin MH
AD  - Social and Preventive Medicine, Sungkyunkwan University School of Medicine,
      Seoul, South Korea.
FAU - Kim, Yeon-Jung
AU  - Kim YJ
AD  - Division of Structural and Functional Genomics, Center for Genome Science, Korea 
      National Institute of Health, Chungcheongbuk-do, Korea.
FAU - Oh, Bermseok
AU  - Oh B
AD  - Department of Biomedical Engineering, School of Medicine, Kyung Hee University,
      Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20170413
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Hemoglobins)
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.14.11.- (JMJD1C protein, human)
RN  - EC 1.14.11.- (Jumonji Domain-Containing Histone Demethylases)
RN  - EC 1.5.- (Oxidoreductases, N-Demethylating)
RN  - EC 2.1.1.- (tRNA Methyltransferases)
RN  - EC 2.8.4.5 (CDKAL1 protein, human)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Asian Continental Ancestry Group/genetics
MH  - Diabetes Mellitus, Type 2/*epidemiology/genetics/metabolism
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Incidence
MH  - Iron/*metabolism
MH  - Jumonji Domain-Containing Histone Demethylases/*genetics
MH  - KCNQ1 Potassium Channel/*genetics
MH  - Male
MH  - Middle Aged
MH  - Oxidoreductases, N-Demethylating/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
MH  - Sex Factors
MH  - tRNA Methyltransferases/*genetics
EDAT- 2017/04/14 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/14 06:00
PHST- 2016/10/12 [received]
PHST- 2017/03/29 [accepted]
AID - 10.1371/journal.pone.0175681 [doi]
AID - PONE-D-16-40684 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 13;12(4):e0175681. doi: 10.1371/journal.pone.0175681.
      eCollection 2017.

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