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Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study.

Abstract The "accelerator hypothesis" predicts early onset of Type 1 diabetes (T1D) in heavier children. Studies testing direction of correlation between body mass index (BMI) and age at onset of T1D in different continental populations have reported differing results-inverse, direct, and neutral. Evaluating the correlation in diverse ethnic populations is required to generalize the accelerator hypothesis.
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PMID- 28406962
OWN - NLM
STAT- In-Process
DA  - 20170413
LR  - 20170413
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Ethnic differences in association of high body mass index with early onset of
      Type 1 diabetes - Arab ethnicity as case study.
PG  - e0175728
LID - 10.1371/journal.pone.0175728 [doi]
AB  - OBJECTIVE: The "accelerator hypothesis" predicts early onset of Type 1 diabetes
      (T1D) in heavier children. Studies testing direction of correlation between body 
      mass index (BMI) and age at onset of T1D in different continental populations
      have reported differing results-inverse, direct, and neutral. Evaluating the
      correlation in diverse ethnic populations is required to generalize the
      accelerator hypothesis. METHODS: The study cohort comprised 474 Kuwaiti children 
      of Arab ethnicity diagnosed with T1D at age 6 to 18 years during 2011-2013. Age- 
      and sex-adjusted BMI z-scores were calculated by comparing the BMI measured at
      diagnosis with Kuwaiti pediatric population reference data recorded during
      comparable time-period. Multiple linear regression and Pearson correlation
      analyses were performed. RESULTS: BMI z-score was seen inversely associated with 
      onset age (r,-0.28; p-value<0.001). Children with BMI z-score>0 (i.e. BMI
      >national average) showed a stronger correlation (r,-0.38; p-value<0.001) than
      those with BMI z-score<0 (r,-0.19; p-value<0.001); the former group showed
      significantly lower mean onset age than the latter group (9.6+/-2.4 versus
      10.5+/-2.7; p-value<0.001). Observed inverse correlation was consistent with that
      seen in Anglo-saxon, central european, caucasian, and white children while
      inconsistent with that seen in Indian, New Zealander, and Australian children.
      CONCLUSIONS: The accelerator hypothesis generalizes in Arab pediatric population 
      from Kuwait.
FAU - Channanath, Arshad M
AU  - Channanath AM
AD  - Dasman Diabetes Institute, Dasman, Kuwait.
FAU - Elkum, Naser
AU  - Elkum N
AD  - Dasman Diabetes Institute, Dasman, Kuwait.
FAU - Al-Abdulrazzaq, Dalia
AU  - Al-Abdulrazzaq D
AD  - Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait.
FAU - Tuomilehto, Jaakko
AU  - Tuomilehto J
AD  - Dasman Diabetes Institute, Dasman, Kuwait.
FAU - Shaltout, Azza
AU  - Shaltout A
AD  - Dasman Diabetes Institute, Dasman, Kuwait.
FAU - Thanaraj, Thangavel Alphonse
AU  - Thanaraj TA
AUID- ORCID: http://orcid.org/0000-0002-4574-5343
AD  - Dasman Diabetes Institute, Dasman, Kuwait.
LA  - eng
PT  - Journal Article
DEP - 20170413
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2017/04/14 06:00
MHDA- 2017/04/14 06:00
CRDT- 2017/04/14 06:00
PHST- 2017/02/05 [received]
PHST- 2017/03/30 [accepted]
AID - 10.1371/journal.pone.0175728 [doi]
AID - PONE-D-17-04652 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 13;12(4):e0175728. doi: 10.1371/journal.pone.0175728.
      eCollection 2017.

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