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PMID- 28407012
OWN - NLM
STAT- MEDLINE
DA  - 20170413
DCOM- 20170420
LR  - 20170420
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Relation between macular morphology and treatment frequency during twelve months 
      with ranibizumab for diabetic macular edema.
PG  - e0175809
LID - 10.1371/journal.pone.0175809 [doi]
AB  - PURPOSE: To investigate whether baseline optical coherence tomography (OCT)
      parameters can predict the treatment frequency of intravitreal ranibizumab (IVR) 
      injections during the first year in patients with diabetic macular edema (DME)
      treated with pro re nata (PRN) IVR injections. METHODS: We retrospectively
      reviewed 68 eyes of 63 patients with center-involved DME who received IVR
      injections for 12 months or longer according to three monthly IVR injections
      followed by the PRN dosing. We measured the mean retinal thicknesses in the
      individual subfields of the Early Treatment Diabetic Retinopathy Study grid and
      evaluated the qualitative and quantitative parameters on OCT sectional images. We
      investigated the relationship between these OCT parameters at baseline and the
      number of IVR injections during the 12-month follow-up. RESULTS: Three loading
      doses were administered to 10 eyes; four to seven annualized IVR injections were 
      administered to 34 eyes. The number of eyes that received IVR injections
      decreased gradually until month 6 and was almost constant from months 7 to 11. No
      relationships were seen between the treatment frequency and baseline systemic
      factors and the ophthalmic examination findings. Univariate analyses showed that 
      the number of IVR injections during the first year was associated with the mean
      retinal thickness in the individual subfields and the transverse length of the
      disrupted external limiting membrane (ELM) and ellipsoid zone of the
      photoreceptors. Multivariate analysis showed a significant association with the
      thickness in the inferior subfield alone. The treatment frequency during the
      12-month follow-up was not correlated with improved visual acuity but was
      associated with the decrease in the central subfield thickness and disrupted ELM.
      CONCLUSION: The retinal thickness in the inferior subfield predicts the treatment
      frequency during the first year in eyes with DME treated with PRN IVR injections.
FAU - Mori, Yuki
AU  - Mori Y
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Murakami, Tomoaki
AU  - Murakami T
AUID- ORCID: http://orcid.org/0000-0002-0314-8807
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Suzuma, Kiyoshi
AU  - Suzuma K
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Ishihara, Kenji
AU  - Ishihara K
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Yoshitake, Shin
AU  - Yoshitake S
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Fujimoto, Masahiro
AU  - Fujimoto M
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Dodo, Yoko
AU  - Dodo Y
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Yoshitake, Tatsuya
AU  - Yoshitake T
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Miwa, Yuko
AU  - Miwa Y
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
FAU - Tsujikawa, Akitaka
AU  - Tsujikawa A
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
      of Medicine, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170413
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Angiogenesis Inhibitors)
RN  - ZL1R02VT79 (Ranibizumab)
SB  - IM
MH  - Aged
MH  - Angiogenesis Inhibitors/*administration & dosage/therapeutic use
MH  - Diabetic Retinopathy/*drug therapy
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Intravitreal Injections
MH  - Macular Edema/diagnostic imaging/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Ranibizumab/*administration & dosage/therapeutic use
MH  - Retina/*diagnostic imaging
MH  - Retrospective Studies
MH  - Time
MH  - Tomography, Optical Coherence
MH  - Treatment Outcome
EDAT- 2017/04/14 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/14 06:00
PHST- 2017/01/20 [received]
PHST- 2017/03/31 [accepted]
AID - 10.1371/journal.pone.0175809 [doi]
AID - PONE-D-17-02709 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 13;12(4):e0175809. doi: 10.1371/journal.pone.0175809.
      eCollection 2017.

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