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Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study.

Abstract Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as well as values of arterial stiffness differ between women with and without a history of GDM a few years after delivery. We also investigated possible effects of obesity on the results.
PMID
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Authors

Mayor MeshTerms
Keywords

Arterial compliance

Gestational diabetes mellitus

High-sensitivity C-reactive protein

Matrix metalloproteinase-8

Matrix metalloproteinase-9

Pulse wave velocity

Subclinical inflammation

Tissue inhibitor of matrix metalloproteinase-1

Journal Title cardiovascular diabetology
Publication Year Start




PMID- 28407807
OWN - NLM
STAT- MEDLINE
DA  - 20170414
DCOM- 20170418
LR  - 20170418
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Apr 13
TI  - Subclinical inflammation associated with prolonged TIMP-1 upregulation and
      arterial stiffness after gestational diabetes mellitus: a hospital-based cohort
      study.
PG  - 49
LID - 10.1186/s12933-017-0530-x [doi]
AB  - BACKGROUND: Gestational diabetes mellitus (GDM) has significant implications for 
      the future health of the mother. Some clinical studies have suggested subclinical
      inflammation and vascular dysfunction after GDM. We aimed to study whether
      concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor
      of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as
      well as values of arterial stiffness differ between women with and without a
      history of GDM a few years after delivery. We also investigated possible effects 
      of obesity on the results. METHODS: We studied two cohorts-120 women with a
      history of GDM and 120 controls-on average 3.7 years after delivery. Serum
      concentrations of hsCRP were determined by immunonephelometric and
      immunoturbidimetric methods, MMP-8 by immunofluorometric assay, and MMP-9 and
      TIMP-1 by enzyme-linked immunosorbent assays. Pulse wave velocity (PWV) was
      determined using the foot-to-foot velocity method from carotid and femoral
      waveforms by using a SphygmoCor device. Arterial compliance was measured
      non-invasively by an HDI/PulseWaveCR-2000 arterial tonometer. All 240 women were 
      also included in subgroup analyses to study the effect of obesity on the results.
      Multiple linear regression analyses were performed with adjustment for
      confounding factors. RESULTS: PWV after pregnancy complicated by GDM was
      significantly higher than after normal pregnancy, 6.44 +/- 0.83 (SD) vs. 6.17 +/-
      0.74 m/s (p = 0.009). Previous GDM was also one of the significant determinants
      of PWV in multiple linear regression analyses. On the other hand, compliance
      indices of both large (p = 0.092) and small (p = 0.681) arteries did not differ
      between the study cohorts. Serum TIMP-1 levels were significantly increased after
      previous GDM (p = 0.020). However, no differences were found in the serum levels 
      of MMP-8, MMP-9 or hsCRP. In subgroup analyses, there were significantly higher
      concentrations of hsCRP (p = 0.015) and higher PWV (p < 0.001) among obese women 
      compared with non-obese ones. CONCLUSIONS: PWV values were significantly higher
      after GDM compared with normoglycemic pregnancies and were associated with
      prolonged TIMP-1 upregulation. Cardiovascular risk factors were more common in
      participants with high BMI than in those with previous GDM.
FAU - Vilmi-Kerala, Tiina
AU  - Vilmi-Kerala T
AUID- ORCID: http://orcid.org/0000-0002-7442-0038
AD  - School of Medicine, University of Tampere, Tampere, Finland.
      [email protected]
AD  - Department of Obstetrics and Gynecology, Tampere University Hospital, Box 2000,
      33521, Tampere, Finland. [email protected]
FAU - Lauhio, Anneli
AU  - Lauhio A
AD  - Department of Infectious Diseases, Inflammation Center, Helsinki University
      Hospital, Helsinki, Finland.
AD  - Clinicum, University of Helsinki, Helsinki, Finland.
AD  - The Social Insurance Institution of Finland, Benefit Services, Helsinki, Finland.
FAU - Tervahartiala, Taina
AU  - Tervahartiala T
AD  - Department of Oral and Maxillofacial Diseases, Helsinki University and University
      Hospital, Helsinki, Finland.
FAU - Palomaki, Outi
AU  - Palomaki O
AD  - Department of Obstetrics and Gynecology, Tampere University Hospital, Box 2000,
      33521, Tampere, Finland.
FAU - Uotila, Jukka
AU  - Uotila J
AD  - School of Medicine, University of Tampere, Tampere, Finland.
AD  - Department of Obstetrics and Gynecology, Tampere University Hospital, Box 2000,
      33521, Tampere, Finland.
FAU - Sorsa, Timo
AU  - Sorsa T
AD  - Department of Oral and Maxillofacial Diseases, Helsinki University and University
      Hospital, Helsinki, Finland.
AD  - Division of Periodontology, Department of Dental Medicine, Karolinska Institutet,
      Huddinge, Sweden.
FAU - Palomaki, Ari
AU  - Palomaki A
AD  - School of Medicine, University of Tampere, Tampere, Finland.
AD  - Department of Emergency Medicine, Kanta-Hame Central Hospital, Hameenlinna,
      Finland.
LA  - eng
PT  - Journal Article
DEP - 20170413
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (TIMP1 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
SB  - IM
MH  - Adult
MH  - Blood Pressure/physiology
MH  - Cardiovascular Diseases/*blood/physiopathology
MH  - Cohort Studies
MH  - Diabetes, Gestational/*blood/diagnosis
MH  - Female
MH  - Humans
MH  - Inflammation/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Risk Factors
MH  - Tissue Inhibitor of Metalloproteinase-1/*blood
MH  - Up-Regulation
MH  - Vascular Stiffness/*drug effects/physiology
PMC - PMC5390403
OTO - NOTNLM
OT  - Arterial compliance
OT  - Gestational diabetes mellitus
OT  - High-sensitivity C-reactive protein
OT  - Matrix metalloproteinase-8
OT  - Matrix metalloproteinase-9
OT  - Pulse wave velocity
OT  - Subclinical inflammation
OT  - Tissue inhibitor of matrix metalloproteinase-1
EDAT- 2017/04/15 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/15 06:00
PHST- 2017/01/16 [received]
PHST- 2017/04/04 [accepted]
AID - 10.1186/s12933-017-0530-x [doi]
AID - 10.1186/s12933-017-0530-x [pii]
PST - epublish
SO  - Cardiovasc Diabetol. 2017 Apr 13;16(1):49. doi: 10.1186/s12933-017-0530-x.

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