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Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-κB.

Abstract Laryngeal carcinoma remains one of the most common malignancies, and curcumin has been proven to be effective against head and neck cancers in vitro. However, it has not yet been applied in clinical settings due to its low stability. In the current study, we synthesized 34 monocarbonyl analogues of curcumin with stable structures. CA15, which exhibited a stronger inhibited effect on laryngeal cancer cells HEp-2 but a lower toxicity on hepatic cells HL-7702 in MTT assay, was selected for further analysis. The effects of CA15 on cell viability, proliferation, migration, apoptosis, and NF-κB activation were measured using MTT, Transwell migration, flow cytometry, Western blot, and immunofluorescence assays in HEp-2 cells. An NF-κB inhibitor, BMS-345541, as well as curcumin was also tested. Results showed that CA15 induced decreased toxicity towards HL-7702 cells compared to curcumin and BMS-345541. However, similar to BMS-345541 and curcumin, CA15 not only significantly inhibited proliferation and migration and induced caspase-3-dependent apoptosis but also attenuated TNF-α-induced NF-κB activation in HEp-2 cells. These results demonstrated that curcumin analogue CA15 exhibited anticancer effects on laryngeal cancer cells via targeting of NF-κB.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28409156
OWN - NLM
STAT- MEDLINE
DA  - 20170414
DCOM- 20170428
LR  - 20170428
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting
      NF-kappaB.
PG  - 4751260
LID - 10.1155/2017/4751260 [doi]
AB  - Laryngeal carcinoma remains one of the most common malignancies, and curcumin has
      been proven to be effective against head and neck cancers in vitro. However, it
      has not yet been applied in clinical settings due to its low stability. In the
      current study, we synthesized 34 monocarbonyl analogues of curcumin with stable
      structures. CA15, which exhibited a stronger inhibited effect on laryngeal cancer
      cells HEp-2 but a lower toxicity on hepatic cells HL-7702 in MTT assay, was
      selected for further analysis. The effects of CA15 on cell viability,
      proliferation, migration, apoptosis, and NF-kappaB activation were measured using
      MTT, Transwell migration, flow cytometry, Western blot, and immunofluorescence
      assays in HEp-2 cells. An NF-kappaB inhibitor, BMS-345541, as well as curcumin
      was also tested. Results showed that CA15 induced decreased toxicity towards
      HL-7702 cells compared to curcumin and BMS-345541. However, similar to BMS-345541
      and curcumin, CA15 not only significantly inhibited proliferation and migration
      and induced caspase-3-dependent apoptosis but also attenuated TNF-alpha-induced
      NF-kappaB activation in HEp-2 cells. These results demonstrated that curcumin
      analogue CA15 exhibited anticancer effects on laryngeal cancer cells via
      targeting of NF-kappaB.
FAU - Chen, Jian
AU  - Chen J
AUID- ORCID: 0000-0002-0578-9675
AD  - Departments of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat
      Hospital, Fudan University, Shanghai, China.
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
FAU - Zhang, Linlin
AU  - Zhang L
AD  - Departments of Stomatology, The First Affiliated Hospital of Wenzhou Medical
      University, Wenzhou, Zhejiang, China.
FAU - Shu, Yilai
AU  - Shu Y
AUID- ORCID: 0000-0001-5668-5107
AD  - Departments of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat
      Hospital, Fudan University, Shanghai, China.
FAU - Chen, Liping
AU  - Chen L
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
FAU - Zhu, Min
AU  - Zhu M
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
FAU - Yao, Song
AU  - Yao S
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
FAU - Wang, Jiabing
AU  - Wang J
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
FAU - Wu, Jianzhang
AU  - Wu J
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
FAU - Liang, Guang
AU  - Liang G
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
FAU - Wu, Haitao
AU  - Wu H
AUID- ORCID: 0000-0002-7617-2832
AD  - Departments of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat
      Hospital, Fudan University, Shanghai, China.
FAU - Li, Wulan
AU  - Li W
AUID- ORCID: 0000-0001-9442-1743
AD  - Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou
      Medical University, Wenzhou, Zhejiang, China.
AD  - College of Information Science and Computer Engineering, School of the first
      Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20170320
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline)
RN  - 0 (Imidazoles)
RN  - 0 (NF-kappa B)
RN  - 0 (Quinoxalines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Apoptosis/drug effects
MH  - Carcinoma/*drug therapy/genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Curcumin/*administration & dosage/analogs & derivatives
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Imidazoles/administration & dosage
MH  - Laryngeal Neoplasms/*drug therapy/genetics/pathology
MH  - NF-kappa B/antagonists & inhibitors/*biosynthesis
MH  - Quinoxalines/administration & dosage
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
PMC - PMC5376929
EDAT- 2017/04/15 06:00
MHDA- 2017/04/30 06:00
CRDT- 2017/04/15 06:00
PHST- 2016/10/07 [received]
PHST- 2017/02/20 [revised]
PHST- 2017/02/26 [accepted]
AID - 10.1155/2017/4751260 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:4751260. doi: 10.1155/2017/4751260. Epub 2017 Mar 20.

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