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Effect of ancestry on interleukin-10 haplotypes in chronic periodontitis.

Abstract Chronic periodontitis is caused by an inflammatory reaction of the periodontal tissues and alveolar bone. This inflammation is caused by periodontopathic bacteria located in the subgingival biofilm, resulting in inflammatory reactions that may lead to loss of attachment. This tissue destruction is a consequence of host immune and inflammatory responses to specific periodontal pathogens and their metabolic products. Cytokines modulate the immune response, altering its efficiency in the competition against pathogens and increasing periodontal susceptibility. This study investigated genetic polymorphisms in Interleukin 10 (A-1082G, C-819T and C-592A) in 205 individuals from an admixed Brazilian population. A significantly increased risk of developing chronic periodontitis was observed in individuals with low IL-10 production and Amerindian ancestry. These results suggest that the polymorphisms A-1082G, C-819T, and C-592A, which are associated with ancestry, are involved in the susceptibility to the development of chronic periodontitis in an admixed northern Brazilian population.
PMID
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Authors

Mayor MeshTerms

Haplotypes

Keywords
Journal Title frontiers in bioscience (elite edition)
Publication Year Start




PMID- 28410151
OWN - NLM
STAT- MEDLINE
DA  - 20170414
DCOM- 20170426
LR  - 20170426
IS  - 1945-0508 (Electronic)
IS  - 1945-0494 (Linking)
VI  - 9
DP  - 2017 Jun 01
TI  - Effect of ancestry on interleukin-10 haplotypes in chronic periodontitis.
PG  - 276-285
AB  - Chronic periodontitis is caused by an inflammatory reaction of the periodontal
      tissues and alveolar bone. This inflammation is caused by periodontopathic
      bacteria located in the subgingival biofilm, resulting in inflammatory reactions 
      that may lead to loss of attachment. This tissue destruction is a consequence of 
      host immune and inflammatory responses to specific periodontal pathogens and
      their metabolic products. Cytokines modulate the immune response, altering its
      efficiency in the competition against pathogens and increasing periodontal
      susceptibility. This study investigated genetic polymorphisms in Interleukin 10
      (A-1082G, C-819T and C-592A) in 205 individuals from an admixed Brazilian
      population. A significantly increased risk of developing chronic periodontitis
      was observed in individuals with low IL-10 production and Amerindian ancestry.
      These results suggest that the polymorphisms A-1082G, C-819T, and C-592A, which
      are associated with ancestry, are involved in the susceptibility to the
      development of chronic periodontitis in an admixed northern Brazilian population.
FAU - Lopes, Camile de Barros
AU  - Lopes CB
AD  - Laboratory of Human and Medical Genetics, Institute of Biological Sciences,
      Federal University of Para, Belem, PA, Brazil, [email protected]
FAU - Barroso, Regina Fatima Feio
AU  - Barroso RFF
AD  - Health Sciences Institute, Federal University of Para, Belem, PA, Brazil.
FAU - Burbano, Rommel Mario Rodrigues
AU  - Burbano RMR
AD  - Human Cytogenetics Laboratory, Federal University of Para, Belem, PA, Brazil, and
      Oncology Research Center, Federal University of Para, Belem, PA, Brazil.
FAU - Garcia, Patricia Aleixo
AU  - Garcia PA
AD  - Laboratory of Human and Medical Genetics, Institute of Biological Sciences,
      Federal University of Para, Belem, PA, Brazil.
FAU - Pinto, Pablo Diego do Carmo
AU  - Pinto PDDC
AD  - Laboratory of Human and Medical Genetics, Institute of Biological Sciences,
      Federal University of Para, Belem, PA, Brazil.
FAU - Santos, Ney Pereira Carneiro Dos
AU  - Santos NPCD
AD  - Laboratory of Human and Medical Genetics, Institute of Biological Sciences,
      Federal University of Para, Belem, PA, Brazil.
FAU - Santos, Sidney Emanuel Batista
AU  - Santos SEB
AD  - Laboratory of Human and Medical Genetics, Institute of Biological Sciences,
      Federal University of Para, Belem, PA, Brazil,and Oncology Research Center,
      Federal University of Para, Belem, PA, Brazil.
FAU - Ribeiro-Dos-Santos, Andrea Kely Campos
AU  - Ribeiro-Dos-Santos AKC
AD  - Laboratory of Human and Medical Genetics, Institute of Biological Sciences,
      Federal University of Para, Belem, PA, Brazil,and Oncology Research Center,
      Federal University of Para, Belem, PA, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170601
PL  - United States
TA  - Front Biosci (Elite Ed)
JT  - Frontiers in bioscience (Elite edition)
JID - 101485240
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - *Haplotypes
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Periodontitis/*genetics
MH  - Polymorphism, Single Nucleotide
EDAT- 2017/04/15 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/04/15 06:00
AID - 802 [pii]
PST - epublish
SO  - Front Biosci (Elite Ed). 2017 Jun 1;9:276-285.

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