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Early-Onset Alzheimer Disease.

Abstract Early-onset Alzheimer disease (EOAD), with onset in individuals younger than 65 years, although overshadowed by the more common late-onset AD (LOAD), differs significantly from LOAD. EOAD comprises approximately 5% of AD and is associated with delays in diagnosis, aggressive course, and age-related psychosocial needs. One source of confusion is that a substantial percentage of EOAD are phenotypic variants that differ from the usual memory-disordered presentation of typical AD. The management of EOAD is similar to that for LOAD, but special emphasis should be placed on targeting the specific cognitive areas involved and more age-appropriate psychosocial support and education.
PMID
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Authors

Mayor MeshTerms

Disease Progression

Keywords

Alzheimer disease

Dementia

Early-onset dementia

Logopenic variant primary progressive aphasia

Progressive cortical atrophy

Young-onset dementia

Journal Title neurologic clinics
Publication Year Start




PMID- 28410659
OWN - NLM
STAT- MEDLINE
DA  - 20170415
DCOM- 20170420
LR  - 20170420
IS  - 1557-9875 (Electronic)
IS  - 0733-8619 (Linking)
VI  - 35
IP  - 2
DP  - 2017 May
TI  - Early-Onset Alzheimer Disease.
PG  - 263-281
LID - S0733-8619(17)30005-1 [pii]
LID - 10.1016/j.ncl.2017.01.005 [doi]
AB  - Early-onset Alzheimer disease (EOAD), with onset in individuals younger than 65
      years, although overshadowed by the more common late-onset AD (LOAD), differs
      significantly from LOAD. EOAD comprises approximately 5% of AD and is associated 
      with delays in diagnosis, aggressive course, and age-related psychosocial needs. 
      One source of confusion is that a substantial percentage of EOAD are phenotypic
      variants that differ from the usual memory-disordered presentation of typical AD.
      The management of EOAD is similar to that for LOAD, but special emphasis should
      be placed on targeting the specific cognitive areas involved and more
      age-appropriate psychosocial support and education.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Mendez, Mario F
AU  - Mendez MF
AD  - Behavioral Neurology Program, David Geffen School of Medicine at UCLA, 300
      Westwood Plaza, Suite B-200, Box 956975, Los Angeles, CA 90095, USA;
      Neurobehavior Unit, VA Greater Los Angeles Healthcare System, 11301 Wilshire
      Boulevard, Building 206, Los Angeles, CA 90073, USA. Electronic address:
      [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurol Clin
JT  - Neurologic clinics
JID - 8219232
SB  - IM
MH  - Age of Onset
MH  - Alzheimer Disease/*diagnosis/*physiopathology
MH  - *Disease Progression
MH  - Humans
OTO - NOTNLM
OT  - Alzheimer disease
OT  - Dementia
OT  - Early-onset dementia
OT  - Logopenic variant primary progressive aphasia
OT  - Progressive cortical atrophy
OT  - Young-onset dementia
EDAT- 2017/04/16 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/16 06:00
AID - S0733-8619(17)30005-1 [pii]
AID - 10.1016/j.ncl.2017.01.005 [doi]
PST - ppublish
SO  - Neurol Clin. 2017 May;35(2):263-281. doi: 10.1016/j.ncl.2017.01.005.

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