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Frontotemporal Dementia.

Abstract Frontotemporal dementia (FTD) is a heterogeneous disorder with distinct clinical phenotypes associated with multiple neuropathologic entities. Presently, the term FTD encompasses clinical disorders that include changes in behavior, language, executive control, and often motor symptoms. The core FTD spectrum disorders include behavioral variant FTD, nonfluent/agrammatic variant primary progressive aphasia, and semantic variant PPA. Related FTD disorders include frontotemporal dementia with motor neuron disease, progressive supranuclear palsy syndrome, and corticobasal syndrome. In this article, the authors discuss the clinical presentation, diagnostic criteria, neuropathology, genetics, and treatments of these disorders.
PMID
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Frontotemporal Dementias.

Authors

Mayor MeshTerms
Keywords

Corticobasal syndrome (CBS)

Frontotemporal dementia (FTD)

Motor neuron disease

Nonfluent PPA

Primary progressive aphasia

Progressive supranuclear palsy (PSP)

Semantic PPA

Journal Title neurologic clinics
Publication Year Start




PMID- 28410663
OWN - NLM
STAT- MEDLINE
DA  - 20170415
DCOM- 20170420
LR  - 20170420
IS  - 1557-9875 (Electronic)
IS  - 0733-8619 (Linking)
VI  - 35
IP  - 2
DP  - 2017 May
TI  - Frontotemporal Dementia.
PG  - 339-374
LID - S0733-8619(17)30008-7 [pii]
LID - 10.1016/j.ncl.2017.01.008 [doi]
AB  - Frontotemporal dementia (FTD) is a heterogeneous disorder with distinct clinical 
      phenotypes associated with multiple neuropathologic entities. Presently, the term
      FTD encompasses clinical disorders that include changes in behavior, language,
      executive control, and often motor symptoms. The core FTD spectrum disorders
      include behavioral variant FTD, nonfluent/agrammatic variant primary progressive 
      aphasia, and semantic variant PPA. Related FTD disorders include frontotemporal
      dementia with motor neuron disease, progressive supranuclear palsy syndrome, and 
      corticobasal syndrome. In this article, the authors discuss the clinical
      presentation, diagnostic criteria, neuropathology, genetics, and treatments of
      these disorders.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Olney, Nicholas T
AU  - Olney NT
AD  - Department of Neurology, UCSF Memory and Aging Center, San Francisco, CA, USA.
      Electronic address: [email protected]
FAU - Spina, Salvatore
AU  - Spina S
AD  - Department of Neurology, UCSF Memory and Aging Center, San Francisco, CA, USA.
FAU - Miller, Bruce L
AU  - Miller BL
AD  - Department of Neurology, UCSF Memory and Aging Center, San Francisco, CA, USA;
      UCSF School of Medicine, San Francisco, CA, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurol Clin
JT  - Neurologic clinics
JID - 8219232
SB  - IM
MH  - Brain/metabolism/*pathology
MH  - Frontotemporal Dementia/epidemiology/history/*pathology/*physiopathology
MH  - History, 20th Century
MH  - Humans
MH  - Supranuclear Palsy, Progressive/pathology/physiopathology
OTO - NOTNLM
OT  - *Corticobasal syndrome (CBS)
OT  - *Frontotemporal dementia (FTD)
OT  - *Motor neuron disease
OT  - *Nonfluent PPA
OT  - *Primary progressive aphasia
OT  - *Progressive supranuclear palsy (PSP)
OT  - *Semantic PPA
EDAT- 2017/04/16 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/16 06:00
AID - S0733-8619(17)30008-7 [pii]
AID - 10.1016/j.ncl.2017.01.008 [doi]
PST - ppublish
SO  - Neurol Clin. 2017 May;35(2):339-374. doi: 10.1016/j.ncl.2017.01.008.

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