PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

The immunoregulatory effects of co-infection with Fasciola hepatica: From bovine tuberculosis to Johne's disease.

Abstract Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale. This review explores the immunological consequences of co-infection between F. hepatica and other bacterial infections. Arguments are presented suggesting that immunity of cattle to Mycobacterium avium subsp. paratuberculosis is also likely to be affected.
PMID
Related Publications

Mycobacterium avium subsp. paratuberculosis inhibits gamma interferon-induced signaling in bovine monocytes: insights into the cellular mechanisms of Johne's disease.

Experimental Fasciola hepatica infection alters responses to tests used for diagnosis of bovine tuberculosis.

Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response.

Mycobacterium avium subsp. paratuberculosis antibody response, fecal shedding, and antibody cross-reactivity to Mycobacterium bovis in M. avium subsp. paratuberculosis-infected cattle herds vaccinated against Johne's disease.

Co-Infection of cattle with Fasciola hepatica and Mycobacterium bovis- immunological consequences.

Authors

Mayor MeshTerms
Keywords

Bovine tuberculosis

Co-infection

Fasciolosis

Immunomodulation

Johne's disease

Journal Title veterinary journal (london, england : 1997)
Publication Year Start




PMID- 28410676
OWN - NLM
STAT- MEDLINE
DA  - 20170415
DCOM- 20170512
LR  - 20170512
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 222
DP  - 2017 Apr
TI  - The immunoregulatory effects of co-infection with Fasciola hepatica: From bovine 
      tuberculosis to Johne's disease.
PG  - 9-16
LID - S1090-0233(17)30048-5 [pii]
LID - 10.1016/j.tvjl.2017.02.007 [doi]
AB  - Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that
      causes the economically-important disease of fasciolosis in livestock. The threat
      that this disease poses extends beyond its direct effects due to the parasite's
      immunomodulatory effects. Research at this laboratory is focusing on whether this
      immunoregulation can, in animals infected with liver fluke, exert a bystander
      effect on concurrent infections in the host. It has already been established that
      F. hepatica infection reduces cell mediated immune responses to Mycobacterium
      bovis in cattle, and that the interaction between the two pathogens can be
      detected on an epidemiological scale. This review explores the immunological
      consequences of co-infection between F. hepatica and other bacterial infections. 
      Arguments are presented suggesting that immunity of cattle to Mycobacterium avium
      subsp. paratuberculosis is also likely to be affected.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Naranjo Lucena, Amalia
AU  - Naranjo Lucena A
AD  - UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4,
      Ireland. Electronic address: [email protected]
FAU - Garza Cuartero, Laura
AU  - Garza Cuartero L
AD  - UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4,
      Ireland.
FAU - Mulcahy, Grace
AU  - Mulcahy G
AD  - UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4,
      Ireland; Conway Institute, University College Dublin, Belfield, Dublin 4,
      Ireland.
FAU - Zintl, Annetta
AU  - Zintl A
AD  - UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4,
      Ireland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170302
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Cattle Diseases/*immunology/microbiology
MH  - Coinfection/immunology/*veterinary
MH  - Fasciola hepatica/immunology
MH  - Fascioliasis/immunology/*veterinary
MH  - Immunomodulation
MH  - Mycobacterium avium subsp. paratuberculosis/immunology
MH  - Paratuberculosis/*immunology
MH  - Tuberculosis, Bovine/*immunology
OTO - NOTNLM
OT  - Bovine tuberculosis
OT  - Co-infection
OT  - Fasciolosis
OT  - Immunomodulation
OT  - Johne's disease
EDAT- 2017/04/16 06:00
MHDA- 2017/05/13 06:00
CRDT- 2017/04/16 06:00
PHST- 2016/07/26 [received]
PHST- 2017/02/24 [revised]
PHST- 2017/02/27 [accepted]
AID - S1090-0233(17)30048-5 [pii]
AID - 10.1016/j.tvjl.2017.02.007 [doi]
PST - ppublish
SO  - Vet J. 2017 Apr;222:9-16. doi: 10.1016/j.tvjl.2017.02.007. Epub 2017 Mar 2.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>