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Hereditary Kidney Cancer Syndromes and Surgical Management of the Small Renal Mass.

Abstract The management of patients with hereditary kidney cancers presents unique challenges to clinicians. In addition to an earlier age of onset compared with patients with sporadic kidney cancer, those with hereditary kidney cancer syndromes often present with bilateral and/or multifocal renal tumors and are at risk for multiple de novo lesions. This population of patients may also present with extrarenal manifestations, which adds an additional layer of complexity. Physicians who manage these patients should be familiar with the underlying clinical characteristics of each hereditary kidney cancer syndrome and the suggested surgical approaches and recommendations of genetic testing for at-risk individuals.
PMID
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Authors

Mayor MeshTerms
Keywords

Germline alterations

Hereditary syndrome

Multifocal kidney cancer

Nephron-sparing surgery

Renal cell carcinoma

Journal Title the urologic clinics of north america
Publication Year Start




PMID- 28411908
OWN - NLM
STAT- In-Process
DA  - 20170416
LR  - 20170416
IS  - 1558-318X (Electronic)
IS  - 0094-0143 (Linking)
VI  - 44
IP  - 2
DP  - 2017 May
TI  - Hereditary Kidney Cancer Syndromes and Surgical Management of the Small Renal
      Mass.
PG  - 155-167
LID - S0094-0143(16)30129-X [pii]
LID - 10.1016/j.ucl.2016.12.002 [doi]
AB  - The management of patients with hereditary kidney cancers presents unique
      challenges to clinicians. In addition to an earlier age of onset compared with
      patients with sporadic kidney cancer, those with hereditary kidney cancer
      syndromes often present with bilateral and/or multifocal renal tumors and are at 
      risk for multiple de novo lesions. This population of patients may also present
      with extrarenal manifestations, which adds an additional layer of complexity.
      Physicians who manage these patients should be familiar with the underlying
      clinical characteristics of each hereditary kidney cancer syndrome and the
      suggested surgical approaches and recommendations of genetic testing for at-risk 
      individuals.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Nguyen, Kevin A
AU  - Nguyen KA
AD  - Department of Urology, Yale School of Medicine, 789 Howard Avenue, New Haven, CT 
      06520, USA.
FAU - Syed, Jamil S
AU  - Syed JS
AD  - Department of Urology, Yale School of Medicine, 789 Howard Avenue, New Haven, CT 
      06520, USA.
FAU - Shuch, Brian
AU  - Shuch B
AD  - Department of Radiology, Yale School of Medicine, PO Box 208058, New Haven, CT
      06520-8058, USA; Department of Urology, Yale School of Medicine, PO Box 208058,
      New Haven, CT 06520-8058, USA. Electronic address: [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170314
PL  - United States
TA  - Urol Clin North Am
JT  - The Urologic clinics of North America
JID - 0423221
OTO - NOTNLM
OT  - Germline alterations
OT  - Hereditary syndrome
OT  - Multifocal kidney cancer
OT  - Nephron-sparing surgery
OT  - Renal cell carcinoma
EDAT- 2017/04/17 06:00
MHDA- 2017/04/17 06:00
CRDT- 2017/04/17 06:00
AID - S0094-0143(16)30129-X [pii]
AID - 10.1016/j.ucl.2016.12.002 [doi]
PST - ppublish
SO  - Urol Clin North Am. 2017 May;44(2):155-167. doi: 10.1016/j.ucl.2016.12.002. Epub 
      2017 Mar 14.

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