PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion.

Abstract A major cause of spontaneous abortions is chromosomal abnormality of foetal cells. We report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetus with Turner syndrome. The Turner syndrome villus induced pluripotent stem cell line is transgene free, retains the original XO karyotype, expresses pluripotency markers and undergoes trilineage differentiation. This pluripotent stem cell model of Turner syndrome should serve as a tool to study the developmental abnormalities of foetus and placenta that lead to early embryo lethality and profound symptoms like infertility in 45 XO survivors.
PMID
Related Publications

Human embryonic stem cells as models for aneuploid chromosomal syndromes.

No evidence for chromosomal mosaicism in multiple tissues of 10 patients with 45, XO Turner syndrome.

Result and pedigree analysis of spontaneously abortion villus chromosome detecting by FISH.

Studying early lethality of 45,XO (Turner's syndrome) embryos using human embryonic stem cells.

Chorionic villus cell culture and karyotype analysis in 110 cases of early spontaneous abortion.

Authors

Mayor MeshTerms
Keywords

45 XO embryos

Chromosomal abnormality

Early embryo lethality

Pluripotent stem cell model of Turner syndrome

Journal Title stem cell research
Publication Year Start




PMID- 28412999
OWN - NLM
STAT- In-Process
DA  - 20170417
LR  - 20170417
IS  - 1876-7753 (Electronic)
IS  - 1873-5061 (Linking)
VI  - 19
DP  - 2017 Mar
TI  - Generation of an induced pluripotent stem cell line from chorionic villi of a
      Turner syndrome spontaneous abortion.
PG  - 12-16
LID - S1873-5061(16)30215-X [pii]
LID - 10.1016/j.scr.2016.12.016 [doi]
AB  - A major cause of spontaneous abortions is chromosomal abnormality of foetal
      cells. We report the generation of an induced pluripotent stem cell line from the
      fibroblasts isolated from chorionic villi of an early spontaneously aborted
      foetus with Turner syndrome. The Turner syndrome villus induced pluripotent stem 
      cell line is transgene free, retains the original XO karyotype, expresses
      pluripotency markers and undergoes trilineage differentiation. This pluripotent
      stem cell model of Turner syndrome should serve as a tool to study the
      developmental abnormalities of foetus and placenta that lead to early embryo
      lethality and profound symptoms like infertility in 45 XO survivors.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Parveen, Shagufta
AU  - Parveen S
AD  - School of Regenerative Medicine, Manipal University, GKVK post, Bellary Road,
      Bengaluru 560065, Karnataka, India. Electronic address:
      [email protected]
FAU - Panicker, M M
AU  - Panicker MM
AD  - National Centre for Biological Sciences, (TIFR), GKVK Campus, Bellary Road,
      Bengaluru 560065, Karnataka, India. Electronic address: [email protected]
FAU - Gupta, Pawan Kumar
AU  - Gupta PK
AD  - Stempeutics Research Pvt. Ltd., Whitefield, Bengaluru 560066, Karnataka, India.
      Electronic address: [email protected]
LA  - eng
PT  - Journal Article
DEP - 20161213
PL  - England
TA  - Stem Cell Res
JT  - Stem cell research
JID - 101316957
OTO - NOTNLM
OT  - 45 XO embryos
OT  - Chromosomal abnormality
OT  - Early embryo lethality
OT  - Pluripotent stem cell model of Turner syndrome
EDAT- 2017/04/18 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/18 06:00
PHST- 2016/11/26 [received]
PHST- 2016/12/06 [accepted]
AID - S1873-5061(16)30215-X [pii]
AID - 10.1016/j.scr.2016.12.016 [doi]
PST - ppublish
SO  - Stem Cell Res. 2017 Mar;19:12-16. doi: 10.1016/j.scr.2016.12.016. Epub 2016 Dec
      13.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>