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Acute ethanol exposure during late mouse neurodevelopment results in long-term deficits in memory retrieval, but not in social responsiveness.

Abstract Prenatal alcohol exposure can result in neurological changes in affected individuals and may result in the emergence of a broad spectrum of neurobehavioral abnormalities termed fetal alcohol spectrum disorders (FASD). The effects of ethanol exposure during development are both time and dose dependent. Although many animal models of FASD use more chronic ethanol exposure, acute developmental alcohol exposure may also cause long-lasting neuronal changes. Our research employed behavioral measures to assess the effects of a single early postnatal ethanol intoxication event in mice.
PMID
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Authors

Mayor MeshTerms
Keywords

adult behavior

binge drinking

development

ethanol

fetal alcohol spectrum disorders

learning/memory

mouse model

Journal Title brain and behavior
Publication Year Start




PMID- 28413697
OWN - NLM
STAT- In-Process
DA  - 20170417
LR  - 20170420
IS  - 2162-3279 (Electronic)
VI  - 7
IP  - 4
DP  - 2017 Apr
TI  - Acute ethanol exposure during late mouse neurodevelopment results in long-term
      deficits in memory retrieval, but not in social responsiveness.
PG  - e00636
LID - 10.1002/brb3.636 [doi]
AB  - OBJECTIVE: Prenatal alcohol exposure can result in neurological changes in
      affected individuals and may result in the emergence of a broad spectrum of
      neurobehavioral abnormalities termed fetal alcohol spectrum disorders (FASD). The
      effects of ethanol exposure during development are both time and dose dependent. 
      Although many animal models of FASD use more chronic ethanol exposure, acute
      developmental alcohol exposure may also cause long-lasting neuronal changes. Our 
      research employed behavioral measures to assess the effects of a single early
      postnatal ethanol intoxication event in mice. MATERIALS AND METHODS: Mice were
      dosed at postnatal day 6 (a 2.5 g/kg dose of ethanol or a saline control
      administered twice, 2 hr apart) as a model of third trimester binge drinking in
      humans. This exposure was followed by behavioral assessment in male mice at 1
      month (1M) and at 4 months of age (4M), using the Barnes maze (for
      learning/memory retrieval), exploratory behavior, and a social responsiveness
      task. RESULTS: Ethanol-exposed mice appeared to be less motivated to complete the
      Barnes maze at 1M, but were able to successfully learn the maze. However,
      deficits in long-term spatial memory retrieval were observed in ethanol-exposed
      mice when the Barnes maze recall was measured at 4M. No significant differences
      were found in open field behavior or social responsiveness at 1M or 4M of age.
      CONCLUSIONS: Acute ethanol exposure at P6 in mice leads to mild but long-lasting 
      deficits in long-term spatial memory. Results suggest that even brief acute
      exposure to high ethanol levels during the third trimester equivalent of human
      pregnancy may have a permanent negative impact on the neurological functioning of
      the offspring.
FAU - Houle, Katherine
AU  - Houle K
AD  - Division of Pulmonary and Critical Care MedicineMedical College of South
      CarolinaCharlestonSCUSA.
AD  - Department of BiologyRandolph-Macon CollegeAshlandVAUSA.
FAU - Abdi, Myshake
AU  - Abdi M
AD  - Department of BiologyHampden-Sydney CollegeFarmvilleVAUSA.
FAU - Clabough, Erin B D
AU  - Clabough EBD
AUID- ORCID: 0000-0003-4295-2272
AD  - Department of BiologyHampden-Sydney CollegeFarmvilleVAUSA.
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
PMC - PMC5390829
OTO - NOTNLM
OT  - adult behavior
OT  - binge drinking
OT  - development
OT  - ethanol
OT  - fetal alcohol spectrum disorders
OT  - learning/memory
OT  - mouse model
EDAT- 2017/04/18 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/18 06:00
PHST- 2016/01/04 [received]
PHST- 2016/08/30 [revised]
PHST- 2016/11/03 [accepted]
AID - 10.1002/brb3.636 [doi]
AID - BRB3636 [pii]
PST - epublish
SO  - Brain Behav. 2017 Mar 21;7(4):e00636. doi: 10.1002/brb3.636. eCollection 2017
      Apr.

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