PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Cerebrospinal fluid and plasma β-endorphin levels in children with cerebral malaria.

Abstract Cerebral malaria (CM) is the most lethal form of malaria, yet its pathogenesis is not fully understood. Cytoadherence, sequestration, alterations in cytokine expression, inflammation, and microvascular obstruction are all hypothesized to be important in the aetio-pathogenesis of coma which characterizes cerebral malaria and the death which sometimes result. Beta (β)-endorphin has been postulated to be involved in the pathogenetic processes of inflammation and cytokine expression, although the exact role is unknown. The aim of this study was to determine the levels of β-endorphin in cerebrospinal fluid (CSF) and plasma of children with CM and compare the levels of β-endorphin in the plasma of children with CM with that of apparently healthy age- and sex-matched controls at Ile-Ife, Nigeria.
PMID
Related Publications
Authors

Mayor MeshTerms
Keywords

beta‐endorphin

cerebral malaria

cerebrospinal fluid

plasma

Journal Title brain and behavior
Publication Year Start




PMID- 28413714
OWN - NLM
STAT- In-Process
DA  - 20170417
LR  - 20170417
IS  - 2162-3279 (Electronic)
VI  - 7
IP  - 4
DP  - 2017 Apr
TI  - Cerebrospinal fluid and plasma beta-endorphin levels in children with cerebral
      malaria.
PG  - e00673
LID - 10.1002/brb3.673 [doi]
AB  - OBJECTIVES: Cerebral malaria (CM) is the most lethal form of malaria, yet its
      pathogenesis is not fully understood. Cytoadherence, sequestration, alterations
      in cytokine expression, inflammation, and microvascular obstruction are all
      hypothesized to be important in the aetio-pathogenesis of coma which
      characterizes cerebral malaria and the death which sometimes result. Beta
      (beta)-endorphin has been postulated to be involved in the pathogenetic processes
      of inflammation and cytokine expression, although the exact role is unknown. The 
      aim of this study was to determine the levels of beta-endorphin in cerebrospinal 
      fluid (CSF) and plasma of children with CM and compare the levels of
      beta-endorphin in the plasma of children with CM with that of apparently healthy 
      age- and sex-matched controls at Ile-Ife, Nigeria. MATERIALS AND METHODS:
      Additional to the standard investigation for CM, CSF and venous blood samples
      were obtained from the subjects for the determination of beta-endorphin levels.
      RESULTS: Forty children with CM were studied along with forty age- and
      sex-matched controls. The mean CSF beta-endorphin (+/- SD) level for the children
      with CM was 1.8 +/- 0.9 pmol/L. The mean plasma beta-endorphin levels at
      admission (3.1 +/- 2.0 pmol/L) and discharge (4.1 +/- 3.3 pmol/L) were higher in 
      children with CM than in the control subjects (2.7 +/- 0.7 pmol/L). However, only
      the mean plasma beta-endorphin levels at discharge was significantly higher than 
      that of controls (p = .012). CONCLUSION: Children with CM had higher mean plasma 
      beta-endorphin levels compared to the controls and there was increased production
      of beta-endorphins in children with CM during the course of the illness.
FAU - Olorunmoteni, Oluwatosin Eunice
AU  - Olorunmoteni OE
AUID- ORCID: 0000-0001-8561-9918
AD  - Department of Paediatrics and Child Health Obafemi Awolowo UniversityIle-IfeOsun 
      StateNigeria.
FAU - Adeodu, Oluwagbemiga Oyewole
AU  - Adeodu OO
AD  - Department of Paediatrics and Child Health Obafemi Awolowo UniversityIle-IfeOsun 
      StateNigeria.
FAU - Oseni, Saheed B A
AU  - Oseni SBA
AD  - Department of Paediatrics and Child Health Obafemi Awolowo UniversityIle-IfeOsun 
      StateNigeria.
FAU - Obuotor, Efere M
AU  - Obuotor EM
AD  - Department of BiochemistryObafemi Awolowo UniversityIle-IfeOsun StateNigeria.
LA  - eng
PT  - Journal Article
DEP - 20170317
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
PMC - PMC5390846
OTO - NOTNLM
OT  - beta-endorphin
OT  - cerebral malaria
OT  - cerebrospinal fluid
OT  - plasma
CRDT- 2017/04/18 06:00
PHST- 2016/05/10 [received]
PHST- 2016/12/20 [revised]
PHST- 2017/01/26 [accepted]
AID - 10.1002/brb3.673 [doi]
AID - BRB3673 [pii]
PST - epublish
SO  - Brain Behav. 2017 Mar 17;7(4):e00673. doi: 10.1002/brb3.673. eCollection 2017
      Apr.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>