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Increasing value and reducing waste in stroke research.

Abstract Stroke is a major burden to patients and society, and resources spent on stroke research must be used efficiently and produce good value in terms of improvements in human health. However, many instances of poor value from stroke research funding have resulted from the way in which stroke research topics have been chosen and how studies have been designed, conducted, analysed, regulated, managed, disseminated, or reported. A cooperative effort of European stroke researchers aimed to identify sources of inefficiency and waste, recommend approaches to increase value, and highlight examples of best practice in stroke research. Evidence suggests that progress has been made, but there is room for much improvement; researchers, funders, regulators, and other stakeholders in stroke research might consider these recommendations when planning new research.
PMID
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Authors

Mayor MeshTerms

Research Design

Stroke

Keywords
Journal Title the lancet. neurology
Publication Year Start




PMID- 28414653
OWN - NLM
STAT- MEDLINE
DA  - 20170417
DCOM- 20170420
LR  - 20170420
IS  - 1474-4465 (Electronic)
IS  - 1474-4422 (Linking)
VI  - 16
IP  - 5
DP  - 2017 May
TI  - Increasing value and reducing waste in stroke research.
PG  - 399-408
LID - S1474-4422(17)30078-9 [pii]
LID - 10.1016/S1474-4422(17)30078-9 [doi]
AB  - Stroke is a major burden to patients and society, and resources spent on stroke
      research must be used efficiently and produce good value in terms of improvements
      in human health. However, many instances of poor value from stroke research
      funding have resulted from the way in which stroke research topics have been
      chosen and how studies have been designed, conducted, analysed, regulated,
      managed, disseminated, or reported. A cooperative effort of European stroke
      researchers aimed to identify sources of inefficiency and waste, recommend
      approaches to increase value, and highlight examples of best practice in stroke
      research. Evidence suggests that progress has been made, but there is room for
      much improvement; researchers, funders, regulators, and other stakeholders in
      stroke research might consider these recommendations when planning new research.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Berge, Eivind
AU  - Berge E
AD  - Department of Internal Medicine and Cardiology, Oslo University Hospital, Oslo,
      Norway. Electronic address: [email protected]
FAU - Salman, Rustam Al-Shahi
AU  - Salman RA
AD  - Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
FAU - van der Worp, H Bart
AU  - van der Worp HB
AD  - Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University 
      Medical Center, Utrecht, the Netherlands.
FAU - Stapf, Christian
AU  - Stapf C
AD  - Department of Neuroscience, CRCHUM, University of Montreal, QC, Canada.
FAU - Sandercock, Peter
AU  - Sandercock P
AD  - Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
FAU - Sprigg, Nikola
AU  - Sprigg N
AD  - Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, 
      Nottingham, UK.
FAU - Macleod, Malcolm R
AU  - Macleod MR
AD  - Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
FAU - Kelly, Peter J
AU  - Kelly PJ
AD  - Stroke Service, Mater University Hospital, Dublin, Ireland; Stroke Clinical
      Trials Network Ireland, University College Dublin, Dublin, Ireland.
FAU - Nederkoorn, Paul J
AU  - Nederkoorn PJ
AD  - Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.
FAU - Ford, Gary A
AU  - Ford GA
AD  - Medical Sciences Division, University of Oxford, Oxford, UK.
CN  - European Stroke Organisation Trials Network Committee
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Lancet Neurol
JT  - The Lancet. Neurology
JID - 101139309
SB  - IM
MH  - Biomedical Research/standards
MH  - Europe
MH  - Humans
MH  - *Research Design
MH  - *Stroke
IR  - Arnold M
FIR - Arnold, Marcel
IR  - Berge E
FIR - Berge, Eivind
IR  - Diez-Tejedor E
FIR - Diez-Tejedor, Exuperio
IR  - Jatuzis D
FIR - Jatuzis, Dalius
IR  - Kelly PJ
FIR - Kelly, Peter J
IR  - Krieger DW
FIR - Krieger, Derk W
IR  - Nederkoorn PJ
FIR - Nederkoorn, Paul J
IR  - Sandercock P
FIR - Sandercock, Peter
IR  - Stapf C
FIR - Stapf, Christian
IR  - Weimar C
FIR - Weimar, Christian
IR  - Ford GA
FIR - Ford, Gary A
IR  - Salman RA
FIR - Salman, Rustam Al-Shahi
EDAT- 2017/04/18 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/18 06:00
PHST- 2016/12/01 [received]
PHST- 2017/02/06 [revised]
PHST- 2017/03/07 [accepted]
AID - S1474-4422(17)30078-9 [pii]
AID - 10.1016/S1474-4422(17)30078-9 [doi]
PST - ppublish
SO  - Lancet Neurol. 2017 May;16(5):399-408. doi: 10.1016/S1474-4422(17)30078-9.

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