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Serum C-reactive protein concentrations in Nova Scotia Duck Tolling Retrievers with immune-mediated rheumatic disease.

Abstract Nova Scotia Duck Tolling Retrievers (NSDTRs) are a dog breed often affected by immune-mediated rheumatic disease (IMRD), a disorder characterised by chronic stiffness and joint pain. Most, but not all, dogs with IMRD, have antinuclear antibodies (ANA), which are also commonly present in the autoimmune disease systemic lupus erythematosus (SLE). The clinical and diagnostic findings of IMRD indicate that it is an SLE-related disorder. C-reactive protein (CRP), an acute phase protein, is a quantitative marker of inflammation for many diseases and is used for diagnosing and monitoring systemic inflammation in both humans and dogs. However, in human SLE, CRP concentrations are often elevated but correlate poorly with disease activity; they can be low in individual patients with active disease. The aim of the study was to investigate CRP in a group of NSDTRs with the SLE-related disorder IMRD. The hypothesis was that CRP concentrations would be increased in dogs with IMRD compared to healthy dogs, but that the increase would be mild. Serum CRP concentrations were measured in 18 IMRD-affected NSDTRs and 19 healthy control NSDTRs using two different canine-specific CRP assays. Dogs with IMRD and ANA had higher CRP concentrations than the control dogs, but the concentrations were below the clinical decision limit for systemic inflammation for most of the IMRD dogs. These results indicate that CRP concentrations were increased in dogs with IMRD and ANA, but the increase was mild, similar to what has been observed in human SLE.
PMID
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Authors

Mayor MeshTerms
Keywords

C-reactive protein

Canine

Immune-mediated rheumatic disease

Nova Scotia Duck Tolling Retriever

Systemic lupus erythematosus

Journal Title acta veterinaria scandinavica
Publication Year Start




PMID- 28416005
OWN - NLM
STAT- MEDLINE
DA  - 20170418
DCOM- 20170426
LR  - 20170426
IS  - 1751-0147 (Electronic)
IS  - 0044-605X (Linking)
VI  - 59
IP  - 1
DP  - 2017 Apr 17
TI  - Serum C-reactive protein concentrations in Nova Scotia Duck Tolling Retrievers
      with immune-mediated rheumatic disease.
PG  - 21
LID - 10.1186/s13028-017-0289-9 [doi]
AB  - Nova Scotia Duck Tolling Retrievers (NSDTRs) are a dog breed often affected by
      immune-mediated rheumatic disease (IMRD), a disorder characterised by chronic
      stiffness and joint pain. Most, but not all, dogs with IMRD, have antinuclear
      antibodies (ANA), which are also commonly present in the autoimmune disease
      systemic lupus erythematosus (SLE). The clinical and diagnostic findings of IMRD 
      indicate that it is an SLE-related disorder. C-reactive protein (CRP), an acute
      phase protein, is a quantitative marker of inflammation for many diseases and is 
      used for diagnosing and monitoring systemic inflammation in both humans and dogs.
      However, in human SLE, CRP concentrations are often elevated but correlate poorly
      with disease activity; they can be low in individual patients with active
      disease. The aim of the study was to investigate CRP in a group of NSDTRs with
      the SLE-related disorder IMRD. The hypothesis was that CRP concentrations would
      be increased in dogs with IMRD compared to healthy dogs, but that the increase
      would be mild. Serum CRP concentrations were measured in 18 IMRD-affected NSDTRs 
      and 19 healthy control NSDTRs using two different canine-specific CRP assays.
      Dogs with IMRD and ANA had higher CRP concentrations than the control dogs, but
      the concentrations were below the clinical decision limit for systemic
      inflammation for most of the IMRD dogs. These results indicate that CRP
      concentrations were increased in dogs with IMRD and ANA, but the increase was
      mild, similar to what has been observed in human SLE.
FAU - Bremer, Hanna Dorotea
AU  - Bremer HD
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal
      Science, Swedish University of Agricultural Sciences, Box 7054, 750 07, Uppsala, 
      Sweden. [email protected]
FAU - Hillstrom, Anna
AU  - Hillstrom A
AD  - Clinical Pathology Laboratory, University Animal Hospital, Swedish University of 
      Agricultural Sciences, Uppsala, Sweden.
FAU - Kanahols, Malin
AU  - Kanahols M
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal
      Science, Swedish University of Agricultural Sciences, Box 7054, 750 07, Uppsala, 
      Sweden.
FAU - Hagman, Ragnvi
AU  - Hagman R
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal
      Science, Swedish University of Agricultural Sciences, Box 7054, 750 07, Uppsala, 
      Sweden.
FAU - Hansson-Hamlin, Helene
AU  - Hansson-Hamlin H
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal
      Science, Swedish University of Agricultural Sciences, Box 7054, 750 07, Uppsala, 
      Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170417
PL  - England
TA  - Acta Vet Scand
JT  - Acta veterinaria Scandinavica
JID - 0370400
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Animals
MH  - C-Reactive Protein/*metabolism
MH  - Dog Diseases/blood/*diagnosis/immunology
MH  - Dogs
MH  - Female
MH  - Lupus Erythematosus, Systemic/blood/diagnosis/immunology/*veterinary
MH  - Male
MH  - Rheumatic Diseases/blood/diagnosis/immunology/*veterinary
MH  - Sweden
PMC - PMC5392944
OTO - NOTNLM
OT  - C-reactive protein
OT  - Canine
OT  - Immune-mediated rheumatic disease
OT  - Nova Scotia Duck Tolling Retriever
OT  - Systemic lupus erythematosus
EDAT- 2017/04/19 06:00
MHDA- 2017/04/27 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/09/01 [received]
PHST- 2017/04/07 [accepted]
AID - 10.1186/s13028-017-0289-9 [doi]
AID - 10.1186/s13028-017-0289-9 [pii]
PST - epublish
SO  - Acta Vet Scand. 2017 Apr 17;59(1):21. doi: 10.1186/s13028-017-0289-9.

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