OWN - NLM
DA - 20170418
LR - 20170419
IS - 1559-131X (Electronic)
IS - 1357-0560 (Linking)
VI - 34
IP - 5
DP - 2017 May
TI - Radiofrequency versus microwave ablation for treatment of the lung tumours:
LUMIRA (lung microwave radiofrequency) randomized trial.
PG - 96
LID - 10.1007/s12032-017-0946-x [doi]
AB - The LUMIRA trial evaluated the effectiveness of radiofrequency (RFA) and
microwave ablation (MWA) in lung tumours ablation and defining more precisely
their fields of application. It is a controlled prospective multi-centre random
trial with 1:1 randomization. Fifty-two patients in stage IV disease (15 females
and 37 males, mean age 69 y.o., range 40-87) were included. We randomized the
patients in two different subgroups: MWA group and RFA group. For each group, we
evaluated the technical and clinical success, the overall survival and
complication rate. Inter-group difference was compared using Chi-square test or
Fisher's exact test for categorical variables and one-way ANOVA test for
continuous variables. For RFA group, there was a significant reduction in tumour
size only between 6 and 12 months (p value = 0.0014). For MWA group, there was a
significant reduction in tumour size between 6 and 12 months (p value = 0.0003)
and between pre-therapy and 12 months (p value = 0.0215). There were not
significant differences between the two groups in terms of survival time (p value
= 0.883), while the pain level in MWA group was significantly less than in RFA
group (1.79 < 3.25, p value = 0.0043). In conclusion, our trial confirms RFA and
MWA are both excellent choices in terms of efficacy and safety in lung tumour
treatments. However, when compared to RFA therapy, MWA produced a less
intraprocedural pain and a significant reduction in tumour mass.
FAU - Macchi, M
AU - Macchi M
AD - Department of Radiology, Circolo e Fondazione Macchi Hospital, Insubria
University, Varese, Italy.
FAU - Belfiore, M P
AU - Belfiore MP
AD - Department of Experimental Medicine, University of Campania "Luigi Vanvitelli",
FAU - Floridi, C
AU - Floridi C
AD - Radiology Department, Fatebenefratelli Hospital, Milan, Italy.
FAU - Serra, N
AU - Serra N
AD - Department of Radiology and Radiotherapy, University of Campania "Luigi
Vanvitelli", Naples, Italy.
FAU - Belfiore, G
AU - Belfiore G
AD - Department of Radiology, Sant'Anna e San Sebastiano Hospital, Caserta, Italy.
FAU - Carmignani, L
AU - Carmignani L
AD - Interventional Radiology Unit, San Jacopo Hospital, Pistoia, Italy.
FAU - Grasso, R F
AU - Grasso RF
AD - Department of Diagnostic and Interventional Radiology, Campus Bio-Medico
University, Rome, Italy.
FAU - Mazza, E
AU - Mazza E
AD - Interventional Radiology Unit, Careggi Hospital, Florence, Italy.
FAU - Pusceddu, C
AU - Pusceddu C
AD - Division of Interventional Radiology, Department of Oncological Radiology,
Oncological Hospital "A. Businco", Cagliari, Italy.
FAU - Brunese, L
AU - Brunese L
AD - Department of Radiology, University of Molise, Campobasso, Italy.
FAU - Carrafiello, G
AU - Carrafiello G
AD - Department of Radiology, San Paolo Hospital, University of Milan, Milan, Italy.
LA - eng
PT - Journal Article
PT - Multicenter Study
PT - Randomized Controlled Trial
DEP - 20170418
PL - United States
TA - Med Oncol
JT - Medical oncology (Northwood, London, England)
JID - 9435512
SB - IM
MH - Adult
MH - Aged
MH - Aged, 80 and over
MH - Catheter Ablation/*methods
MH - Female
MH - Humans
MH - Lung Neoplasms/pathology/*surgery
MH - Male
MH - Microwaves/*therapeutic use
MH - Middle Aged
MH - Neoplasm Staging
MH - Prospective Studies
OTO - NOTNLM
OT - *Ablation treatment
OT - *Lung cancer
OT - *Microwave
OT - *Radiofrequency
EDAT- 2017/04/19 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/19 06:00
PHST- 2017/02/27 [received]
PHST- 2017/04/04 [accepted]
AID - 10.1007/s12032-017-0946-x [doi]
AID - 10.1007/s12032-017-0946-x [pii]
PST - ppublish
SO - Med Oncol. 2017 May;34(5):96. doi: 10.1007/s12032-017-0946-x. Epub 2017 Apr 18.