PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28418494
OWN - NLM
STAT- MEDLINE
DA  - 20170418
DCOM- 20170426
LR  - 20170426
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 4
DP  - 2017 Apr 01
TI  - Prevalence, Natural Course, and Prognostic Role of Refractile Drusen in
      Age-Related Macular Degeneration.
PG  - 2198-2206
LID - 10.1167/iovs.16-20781 [doi]
AB  - Purpose: To report prevalence, clinical characteristics, and prognostic
      significance of refractile drusen in eyes with intermediate age-related macular
      degeneration (AMD). Methods: Presence of refractile drusen by color fundus
      photography (CFP), corresponding findings by multimodal imaging, and longitudinal
      changes with annual examinations for up to 4 years were analyzed within a
      prospective natural history study of 98 eyes with non-late AMD of 98 patients
      (Age-Related Eye Disease Study [AREDS] stages 3 and 4). Results: A total of 115
      refractile drusen were detected at baseline in 20 eyes (20.4%). Refractile drusen
      typically showed hyperreflectivity by infrared (80.9%) and blue (93.9%)
      reflectance imaging, appearing more distinct when compared to CFP. Laminar
      intense hyperreflectivity of Bruch's membrane was detected in 31 lesions by
      spectral-domain optical coherence tomography and was strongly related to atrophy 
      development (23 out of 31 lesions). Presence of refractile drusen at baseline was
      overall associated with later development of geographic atrophy (GA) (9/20 eyes
      versus 6/78 eyes, P < 0.001). Spontaneous regression without evident atrophy
      occurred in seven lesions. Conclusions: Refractile drusen are a relative common
      phenotype in intermediate AMD and appear to confer risk for the development of
      late AMD. While not all lesions develop late AMD and regression may also occur,
      distinct subphenotypes as identified by multimodal imaging may not only be
      visible earlier but also be topographically associated with the risk for GA
      development. Recognizing the characteristic pattern on multimodal imaging would
      inform physicians for identification of the lesion and its clinical history.
FAU - Oishi, Akio
AU  - Oishi A
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Thiele, Sarah
AU  - Thiele S
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Nadal, Jennifer
AU  - Nadal J
AD  - Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn,
      Bonn, Germany.
FAU - Oishi, Maho
AU  - Oishi M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Fleckenstein, Monika
AU  - Fleckenstein M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Schmid, Matthias
AU  - Schmid M
AD  - Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn,
      Bonn, Germany.
FAU - Holz, Frank G
AU  - Holz FG
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Schmitz-Valckenberg, Steffen
AU  - Schmitz-Valckenberg S
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - Fundus Oculi
MH  - Humans
MH  - Macular Degeneration/diagnosis/diagnostic imaging/*pathology
MH  - Male
MH  - Prevalence
MH  - Prognosis
MH  - Prospective Studies
MH  - Retina/diagnostic imaging/pathology
MH  - Retinal Drusen/diagnostic imaging/*epidemiology
EDAT- 2017/04/19 06:00
MHDA- 2017/04/27 06:00
CRDT- 2017/04/19 06:00
AID - 2619009 [pii]
AID - 10.1167/iovs.16-20781 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2198-2206. doi:
      10.1167/iovs.16-20781.

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