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Course of Sodium Iodate-Induced Retinal Degeneration in Albino and Pigmented Mice.

Abstract To characterize the course of sodium iodate (SI)-induced retinal degeneration in young adult albino and pigmented mice.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28418497
OWN - NLM
STAT- In-Process
DA  - 20170418
LR  - 20170418
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 4
DP  - 2017 Apr 01
TI  - Course of Sodium Iodate-Induced Retinal Degeneration in Albino and Pigmented
      Mice.
PG  - 2239-2249
LID - 10.1167/iovs.16-21255 [doi]
AB  - Purpose: To characterize the course of sodium iodate (SI)-induced retinal
      degeneration in young adult albino and pigmented mice. Methods: Single
      intraperitoneal (IP) injections of SI (25, 50, and 100 mg/kg) were performed in
      7- to 8-week-old BALB/c and C57Bl/6J mice. Retinal function and structure was
      assessed at baseline, 24 hours, 3 days, 1, 2, 3, and 4 weeks postinjection by
      optokinetic tracking response, ERG, optical coherence tomography (OCT), and
      histologic and immunohistochemical techniques. Results: The 50 mg/kg SI dosage
      was selected after dose ranging due to consistent retinal effects and lack of
      systemic toxicity. Time-dependent deterioration in retinal function and
      morphology was consistently observed between 1 and 4 weeks in all measured
      parameters. These include reduction of ERG responses, thinning of retinal layers 
      as observed by OCT and histology, and loss of RPE nuclei. Immunohistochemistry
      revealed rapid RPE disorganization with loss of tight junctions and markedly
      reduced expression of RPE65 and rod opsin, accompanied by mislocalization of cone
      opsins. Earlier time points displayed variable results, including partial
      recovery of visual acuity at 1 week and supranormal ERG cone responses at 24
      hours, suggesting possible limitations of early intervention and assessment in
      the SI model. Conclusions: A single IP injection of 50 mg/kg SI leads to severe
      RPE injury followed by vision impairment, dysfunction, and loss of photoreceptors
      in both BALB/c and C57Bl/6J mice. This easily induced and reproducible
      noninherited model may serve as a useful tool for seeking and evaluating novel
      therapeutic modalities for the treatment of retinal degenerations caused by
      primary failure of the RPE.
FAU - Chowers, Guy
AU  - Chowers G
AD  - Center for Retinal and Macular Degenerations, Department of Ophthalmology,
      Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Cohen, Matan
AU  - Cohen M
AD  - Center for Retinal and Macular Degenerations, Department of Ophthalmology,
      Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Marks-Ohana, Devora
AU  - Marks-Ohana D
AD  - Center for Retinal and Macular Degenerations, Department of Ophthalmology,
      Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Stika, Shelly
AU  - Stika S
AD  - Center for Retinal and Macular Degenerations, Department of Ophthalmology,
      Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Eijzenberg, Ayala
AU  - Eijzenberg A
AD  - Center for Retinal and Macular Degenerations, Department of Ophthalmology,
      Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Banin, Eyal
AU  - Banin E
AD  - Center for Retinal and Macular Degenerations, Department of Ophthalmology,
      Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Obolensky, Alexey
AU  - Obolensky A
AD  - Center for Retinal and Macular Degenerations, Department of Ophthalmology,
      Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
EDAT- 2017/04/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/19 06:00
AID - 2619439 [pii]
AID - 10.1167/iovs.16-21255 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2239-2249. doi:
      10.1167/iovs.16-21255.

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