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Fatty liver disease determines the progression of coronary artery calcification in a metabolically healthy obese population.

Abstract Metabolically healthy obese (MHO) phenotype describes an obese state with a favorable metabolic profile. However, the prognosis of this subpopulation remains controversial. We aimed to examine whether MHO phenotype is associated with progression of atherosclerotic activity, reflected as the changes in coronary artery calcification (CAC) over time. If so, we sought to determine the role of fatty liver disease (FLD), the hallmark of hepatic steatosis, in this progression.
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Mayor MeshTerms
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Journal Title plos one
Publication Year Start




PMID- 28419118
OWN - NLM
STAT- In-Process
DA  - 20170418
LR  - 20170418
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Fatty liver disease determines the progression of coronary artery calcification
      in a metabolically healthy obese population.
PG  - e0175762
LID - 10.1371/journal.pone.0175762 [doi]
AB  - OBJECTIVES: Metabolically healthy obese (MHO) phenotype describes an obese state 
      with a favorable metabolic profile. However, the prognosis of this subpopulation 
      remains controversial. We aimed to examine whether MHO phenotype is associated
      with progression of atherosclerotic activity, reflected as the changes in
      coronary artery calcification (CAC) over time. If so, we sought to determine the 
      role of fatty liver disease (FLD), the hallmark of hepatic steatosis, in this
      progression. METHODS: We enrolled 1,240 asymptomatic subjects who underwent
      repeated CAC score measurement during routine health examinations. CAC score
      progression was defined as either incident CAC in a population free of CAC at
      baseline, or an increase by >/=2.5 units between the baseline and final square
      root of CAC scores in participants with detectable CAC at baseline. Subjects were
      stratified by body mass index (cut-off, 25.0 kg/m2) and metabolic health state
      using Adult Treatment Panel-III criteria. FLD was assessed via ultrasonography.
      RESULTS: Over 2.9 years of follow-up, 25.2% of total subjects exhibited CAC score
      progression. The MHO phenotype was not significantly associated with CAC score
      progression (multivariate adjusted-odds ratio [OR], 1.45; 95% confidence interval
      [CI], 0.93-2.25), as compared to the metabolically healthy non-obese (MHNO)
      phenotype. However, subgroup analysis indicated that the MHO/FLD phenotype was
      significantly associated with CAC score progression (multivariate adjusted-OR,
      2.37; 95% CI, 1.34-4.16), as compared to the MHNO/no FLD phenotype, whereas the
      MHO/no FLD phenotype was not (multivariate adjusted OR, 1.25; 95% CI, 0.71-2.24).
      CONCLUSIONS: Obese individuals with FLD have an increased risk of atherosclerosis
      progression, despite their healthy metabolic profile. Preventive interventions
      targeting cardiometabolic risk factors should be considered in such individuals, 
      regardless of the weight status.
FAU - Kang, Yu Mi
AU  - Kang YM
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College
      of Medicine, Seoul, Republic of Korea.
FAU - Jung, Chang Hee
AU  - Jung CH
AUID- ORCID: http://orcid.org/0000-0003-4043-2396
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College
      of Medicine, Seoul, Republic of Korea.
FAU - Cho, Yun Kyung
AU  - Cho YK
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College
      of Medicine, Seoul, Republic of Korea.
FAU - Lee, Seung Eun
AU  - Lee SE
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College
      of Medicine, Seoul, Republic of Korea.
FAU - Lee, Min Jung
AU  - Lee MJ
AD  - Department of Health Screening and Promotion Center, Asan Medical Center,
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Hwang, Jenie Yoonoo
AU  - Hwang JY
AD  - Department of Health Screening and Promotion Center, Asan Medical Center,
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Eun Hee
AU  - Kim EH
AD  - Department of Health Screening and Promotion Center, Asan Medical Center,
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Park, Joong-Yeol
AU  - Park JY
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College
      of Medicine, Seoul, Republic of Korea.
FAU - Lee, Woo Je
AU  - Lee WJ
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College
      of Medicine, Seoul, Republic of Korea.
FAU - Kim, Hong-Kyu
AU  - Kim HK
AD  - Department of Health Screening and Promotion Center, Asan Medical Center,
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2017/04/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/12/25 [received]
PHST- 2017/03/30 [accepted]
AID - 10.1371/journal.pone.0175762 [doi]
AID - PONE-D-16-50987 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 18;12(4):e0175762. doi: 10.1371/journal.pone.0175762.
      eCollection 2017.

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