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PMID- 28419138
OWN - NLM
STAT- In-Process
DA  - 20170418
LR  - 20170418
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with 
      scrub typhus.
PG  - e0175890
LID - 10.1371/journal.pone.0175890 [doi]
AB  - BACKGROUND: The aim of this study is to investigate the clinical significance of 
      neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1
      (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus. METHODS:
      From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we
      enrolled 138 patients who were followed up until renal recovery or for at least 3
      months. We measured serum and urine NGAL and KIM-1 levels and evaluated
      prognostic factors affecting scrub typhus-associated AKI. RESULTS: Of the 138
      patients, 25 had scrub typhus-associated AKI. The incidence of AKI was 18.1%; of 
      which 11.6%, 4.3%, and 2.2% were classified as risk, injury, and failure,
      respectively, according to RIFLE criteria. Compared with patients in the non-AKI 
      group, patients in the AKI group were older and showed higher total leukocyte
      counts and hypoalbuminemia or one or more comorbidities such as hypertension (72%
      vs 33%, p<0.01), diabetes (40% vs 14%, p<0.01), or chronic kidney disease (32% vs
      1%, p<0.01). In addition, serum NGAL values (404+/- 269 vs 116+/- 78 ng/mL,
      P<0.001), KIM-1 values (0.80+/- 0.52 vs 0.33+/- 0.68 ng/mL, P<0.001), urine
      NGAL/creatinine values (371+/- 672 vs 27+/- 39 ng/mg, P<0.001) and urine
      KIM-1/creatinine values (4.04+/- 2.43 vs 2.38+/- 1.89 ng/mg, P<0.001) were higher
      in the AKI group than in the non-AKI group. By multivariate logistic regression, 
      serum NGAL and the presence of chronic kidney disease were significant predictors
      of AKI. CONCLUSION: Serum NGAL might be an additive predictor for scrub
      typhus-associated AKI.
FAU - Sun, In O
AU  - Sun IO
AD  - Division of Nephrology, Department of Internal Medicine, Presbyterian Medical
      Center, Jeonju, Korea.
FAU - Shin, Sung Hye
AU  - Shin SH
AD  - Christian Medical Research Center, Presbyterian Medical Center, Jeonju, Korea.
FAU - Cho, A Young
AU  - Cho AY
AD  - Division of Nephrology, Department of Internal Medicine, Presbyterian Medical
      Center, Jeonju, Korea.
FAU - Yoon, Hyun Ju
AU  - Yoon HJ
AD  - Division of Nephrology, Department of Internal Medicine, Presbyterian Medical
      Center, Jeonju, Korea.
FAU - Chang, Mi Yok
AU  - Chang MY
AD  - Division of Infection, Department of Internal Medicine, Presbyterian Medical
      Center, Jeonju, Korea.
FAU - Lee, Kwang Young
AU  - Lee KY
AUID- ORCID: http://orcid.org/0000-0002-5754-1452
AD  - Division of Nephrology, Department of Internal Medicine, Presbyterian Medical
      Center, Jeonju, Korea.
AD  - Christian Medical Research Center, Presbyterian Medical Center, Jeonju, Korea.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2017/04/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/19 06:00
PHST- 2017/01/18 [received]
PHST- 2017/04/02 [accepted]
AID - 10.1371/journal.pone.0175890 [doi]
AID - PONE-D-17-02331 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 18;12(4):e0175890. doi: 10.1371/journal.pone.0175890.
      eCollection 2017.

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