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MICA diversity and linkage disequilibrium with HLA-B alleles in renal-transplant candidates in southern Brazil.

Abstract The major histocompatibility complex (MHC) class I chain-related gene A (MICA) is located centromerically to the human leukocyte antigen (HLA)-B. The short distance between these loci in the MHC indicates the presence of linkage disequilibrium (LD). Similarly to the HLA, the MICA is highly polymorphic, and this polymorphism has not been well documented in different populations. In this study, we estimated the allelic frequencies of MICA and the linkage disequilibrium with HLA-B alleles in 346 renal-transplant candidates in southern Brazil. MICA and HLA were typed using the polymerase chain reaction-sequence-specific primer method (PCR-SSO), combined with the Luminex technology. A total of 19 MICA allele groups were identified. The most frequent allele groups were MICA*008 (21.6%), MICA*002 (17.0%) and MICA*004 (14.8%). The most common haplotypes were MICA*009-B*51 (7.8%), MICA*004-B*44 (6.06%) and MICA*002-B*35 (5.63%). As expected from the proximity of the MICA and HLA-B loci, most haplotypes showed strong LD. Renal patients and healthy subjects in the same region of Brazil showed statistically significant differences in their MICA polymorphisms. The MICA*027 allele group was more frequent in renal patients (Pc = 0.018, OR: 3.421, 95% CI: 1.516-7.722), while the MICA*019 allele group was more frequent in healthy subjects (Pc = 0.001, OR: 0.027, 95% CI: 0.002-0.469). This study provided information on the distribution of MICA polymorphisms and linkage disequilibrium with HLA-B alleles in Brazilian renal-transplant candidates. This information should help to determine the mechanisms of susceptibility to different diseases in patients with chronic kidney disease, and to elucidate the mechanisms involved in allograft rejection associated with MICA polymorphisms in a Brazilian population.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 28419176
OWN - NLM
STAT- In-Process
DA  - 20170418
LR  - 20170418
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - MICA diversity and linkage disequilibrium with HLA-B alleles in renal-transplant 
      candidates in southern Brazil.
PG  - e0176072
LID - 10.1371/journal.pone.0176072 [doi]
AB  - The major histocompatibility complex (MHC) class I chain-related gene A (MICA) is
      located centromerically to the human leukocyte antigen (HLA)-B. The short
      distance between these loci in the MHC indicates the presence of linkage
      disequilibrium (LD). Similarly to the HLA, the MICA is highly polymorphic, and
      this polymorphism has not been well documented in different populations. In this 
      study, we estimated the allelic frequencies of MICA and the linkage
      disequilibrium with HLA-B alleles in 346 renal-transplant candidates in southern 
      Brazil. MICA and HLA were typed using the polymerase chain
      reaction-sequence-specific primer method (PCR-SSO), combined with the Luminex
      technology. A total of 19 MICA allele groups were identified. The most frequent
      allele groups were MICA*008 (21.6%), MICA*002 (17.0%) and MICA*004 (14.8%). The
      most common haplotypes were MICA*009-B*51 (7.8%), MICA*004-B*44 (6.06%) and
      MICA*002-B*35 (5.63%). As expected from the proximity of the MICA and HLA-B loci,
      most haplotypes showed strong LD. Renal patients and healthy subjects in the same
      region of Brazil showed statistically significant differences in their MICA
      polymorphisms. The MICA*027 allele group was more frequent in renal patients (Pc 
      = 0.018, OR: 3.421, 95% CI: 1.516-7.722), while the MICA*019 allele group was
      more frequent in healthy subjects (Pc = 0.001, OR: 0.027, 95% CI: 0.002-0.469).
      This study provided information on the distribution of MICA polymorphisms and
      linkage disequilibrium with HLA-B alleles in Brazilian renal-transplant
      candidates. This information should help to determine the mechanisms of
      susceptibility to different diseases in patients with chronic kidney disease, and
      to elucidate the mechanisms involved in allograft rejection associated with MICA 
      polymorphisms in a Brazilian population.
FAU - Yamakawa, Roger Haruki
AU  - Yamakawa RH
AD  - Department of Basic Health Science, Universidade Estadual de Maringa - Maringa,
      Parana, Brazil.
FAU - Saito, Patricia Keiko
AU  - Saito PK
AD  - Department of Basic Health Science, Universidade Estadual de Maringa - Maringa,
      Parana, Brazil.
FAU - Gelmini, Georgia Fernanda
AU  - Gelmini GF
AD  - Laboratorio de Imunogenetica e Histocompatibilidade, Department of Genetics,
      Universidade Federal do Parana - Curitiba, Parana, Brazil.
FAU - da Silva, Jose Samuel
AU  - da Silva JS
AD  - Laboratorio de Imunogenetica e Histocompatibilidade, Department of Genetics,
      Universidade Federal do Parana - Curitiba, Parana, Brazil.
FAU - Bicalho, Maria da Graca
AU  - Bicalho MDG
AD  - Laboratorio de Imunogenetica e Histocompatibilidade, Department of Genetics,
      Universidade Federal do Parana - Curitiba, Parana, Brazil.
FAU - Borelli, Sueli Donizete
AU  - Borelli SD
AD  - Department of Basic Health Science, Universidade Estadual de Maringa - Maringa,
      Parana, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2017/04/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/11/22 [received]
PHST- 2017/04/05 [accepted]
AID - 10.1371/journal.pone.0176072 [doi]
AID - PONE-D-16-46418 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 18;12(4):e0176072. doi: 10.1371/journal.pone.0176072.
      eCollection 2017.

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