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Use of Corticosteroids in the Treatment of Patients With Diabetic Macular Edema Who Have a Suboptimal Response to Anti-VEGF: Recommendations of an Expert Panel.

Abstract Guidance on the use of corticosteroids in the treatment of diabetic macular edema (DME) is lacking. This study aimed to develop a clinically recommended treatment paradigm for DME with emphasis on the role of corticosteroids.
PMID
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Authors

Mayor MeshTerms

Decision Making

Surveys and Questionnaires

Keywords
Journal Title ophthalmic surgery, lasers & imaging retina
Publication Year Start




PMID- 28419394
OWN - NLM
STAT- MEDLINE
DA  - 20170418
DCOM- 20170502
LR  - 20170502
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 48
IP  - 4
DP  - 2017 Apr 01
TI  - Use of Corticosteroids in the Treatment of Patients With Diabetic Macular Edema
      Who Have a Suboptimal Response to Anti-VEGF: Recommendations of an Expert Panel.
PG  - 291-301
LID - 10.3928/23258160-20170329-03 [doi]
AB  - BACKGROUND AND OBJECTIVE: Guidance on the use of corticosteroids in the treatment
      of diabetic macular edema (DME) is lacking. This study aimed to develop a
      clinically recommended treatment paradigm for DME with emphasis on the role of
      corticosteroids. PATIENTS AND METHODS: An expert panel of nine retinal
      specialists in the United States developed consensus recommendations for DME
      treatment through a modified Delphi process. RESULTS: The panelists typically use
      intravitreal injections of vascular endothelial growth factor (VEGF) antagonists 
      as first-line treatment of DME and switch patients with an inadequate response to
      anti-VEGF therapy (failure of best-corrected visual acuity to improve to 20/40 or
      better because of edema after three to six monthly injections, or a less-than-50%
      reduction in excess macular thickness after three to four monthly injections) to 
      intravitreal corticosteroid treatment. CONCLUSION: Intravitreal corticosteroids
      have a potentially useful role in the treatment of patients with DME who have an 
      inadequate response to intravitreal anti-VEGF therapy. [Ophthalmic Surg Lasers
      Imaging Retina. 2017;48:291-301.].
CI  - (c) 2017 Regillo, Callanan, Do, et al.
FAU - Regillo, Carl D
AU  - Regillo CD
FAU - Callanan, David G
AU  - Callanan DG
FAU - Do, Diana V
AU  - Do DV
FAU - Fine, Howard F
AU  - Fine HF
FAU - Holekamp, Nancy M
AU  - Holekamp NM
FAU - Kuppermann, Baruch D
AU  - Kuppermann BD
FAU - Singer, Michael A
AU  - Singer MA
FAU - Singh, Rishi P
AU  - Singh RP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Glucocorticoids)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Angiogenesis Inhibitors/administration & dosage
MH  - *Decision Making
MH  - Delphi Technique
MH  - Diabetic Retinopathy/complications/diagnosis/*drug therapy
MH  - Expert Testimony/*methods
MH  - Follow-Up Studies
MH  - Glucocorticoids/*administration & dosage
MH  - Humans
MH  - Intravitreal Injections
MH  - Macular Edema/diagnosis/*drug therapy/etiology
MH  - Retrospective Studies
MH  - *Surveys and Questionnaires
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/*antagonists & inhibitors
MH  - Visual Acuity
EDAT- 2017/04/19 06:00
MHDA- 2017/05/04 06:00
CRDT- 2017/04/19 06:00
PHST- 2017/02/07 [received]
PHST- 2017/03/20 [accepted]
AID - 10.3928/23258160-20170329-03 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2017 Apr 1;48(4):291-301. doi:
      10.3928/23258160-20170329-03.

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