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Correlation Between Mesopic Retinal Sensitivity and Optical Coherence Tomographic Metrics of the Outer Retina in Patients With Non-Atrophic Dry Age-Related Macular Degeneration.

Abstract To determine the correlation between mesopic retinal sensitivity and optical coherence tomographic metrics of the outer retina in patients with intermediate age-related macular degeneration (AMD).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title ophthalmic surgery, lasers & imaging retina
Publication Year Start




PMID- 28419396
OWN - NLM
STAT- In-Process
DA  - 20170418
LR  - 20170418
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 48
IP  - 4
DP  - 2017 Apr 01
TI  - Correlation Between Mesopic Retinal Sensitivity and Optical Coherence Tomographic
      Metrics of the Outer Retina in Patients With Non-Atrophic Dry Age-Related Macular
      Degeneration.
PG  - 312-318
LID - 10.3928/23258160-20170329-05 [doi]
AB  - BACKGROUND AND OBJECTIVE: To determine the correlation between mesopic retinal
      sensitivity and optical coherence tomographic metrics of the outer retina in
      patients with intermediate age-related macular degeneration (AMD). PATIENTS AND
      METHODS: Participants with nonatrophic dry AMD underwent mesopic MP-3
      microperimetry (Nidek, Padova, Italy) and both Nidek and Cirrus (Carl Zeiss
      Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD-OCT). The
      volume of the outer retinal layers was measured on the Nidek SD-OCT scans using
      the automatic segmentation algorithm of Navis-EX software. In addition, drusen
      area and volume within a 5-mm circle centered on the fovea were determined using 
      the Cirrus Advanced RPE Analysis Tool. The mean retinal sensitivity at 8 degrees 
      and 10 degrees of fixation (5-mm and 6-mm circles) was calculated for every eye. 
      The correlation between retinal sensitivity and patient age, outer retinal layer 
      volume, drusen area, and drusen volume was assessed. RESULTS: Thirty-seven eyes
      from 25 patients with non-atrophic dry AMD were included in the study. The mean
      age of the patients was 76 years +/- 9 years. The mean sensitivity across the
      whole tested retinal area was 24.9 dB +/- 2.4 dB, with a sensitivity of 25.1 dB
      +/- 2.4 dB within the central 5-mm circle. Drusen area within the central 5-mm
      circle was 0.7 mm2 +/- 0.89 mm2 with a drusen volume of 0.03 mm3 +/- 0.04 mm3.
      Retinal pigment epithelium and photoreceptor outer segment (RPE + OS) volume was 
      1.96 mm3 +/- 0.1 mm3, and outer nuclear layer (ONL) volume was 1.91 mm3 +/- 0.17 
      mm3. There was a significant correlation between RPE + OS volume and retinal
      sensitivity, as well as between patients' age and retinal sensitivity. There was 
      no significant correlation between drusen area or volume and retinal sensitivity,
      nor between ONL volume and retinal sensitivity. CONCLUSION: In eyes with
      nonatrophic AMD, retinal sensitivity is correlated with the RPE + OS volume, but 
      not the ONL volume or the area or volume of drusen. [Ophthalmic Surg Lasers
      Imaging Retina. 2017;48:312-318.].
CI  - Copyright 2017, SLACK Incorporated.
FAU - Tepelus, Tudor C
AU  - Tepelus TC
FAU - Hariri, Amir H
AU  - Hariri AH
FAU - Al-Sheikh, Mayss
AU  - Al-Sheikh M
FAU - Sadda, SriniVas R
AU  - Sadda SR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
EDAT- 2017/04/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/06/22 [received]
PHST- 2017/01/24 [accepted]
AID - 10.3928/23258160-20170329-05 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2017 Apr 1;48(4):312-318. doi:
      10.3928/23258160-20170329-05.

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