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Cytokine and adipokine are biofactors can act in blood and colostrum of obese mothers.

Abstract Breast milk contains bioactive components that contribute to newborn development. However, colostrum may undergo biochemical and immunological changes as a function of maternal overweight and obesity. To investigate this hypothesis, this study determined the levels of hormones and immunological markers in the serum and colostrum of overweight and obese mothers. Colostrum and serum samples were collected from 15 normoweight, 15 overweight, and 15 obese women for determination of leptin, adiponectin, cytokines (TNF-α, IL-6, IL-10), and C-reactive protein (CRP). Obese mothers exhibited higher levels of serum TNF-α, IL-6, and CRP, serum and colostrum leptin and colostrum adiponectin and lower levels of serum adiponectin. Leptin levels in maternal serum and colostrum were positively correlated, as was pre-pregnancy BMI and serum TNF-α, IL-6, CRP, and leptin. Adiponectin levels in colostrum and serum were negatively correlated. The results suggest that obesity changes hormonal and immunological components of maternal serum and colostrum. The modifications can have short-term and long-term effects on newborn development. © 2016 BioFactors, 43(2):243-250, 2017.
PMID
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Authors

Mayor MeshTerms
Keywords

adiponectin

cytokines

leptin

maternal obesity

Journal Title biofactors (oxford, england)
Publication Year Start




PMID- 28419655
OWN - NLM
STAT- In-Process
DA  - 20170418
LR  - 20170418
IS  - 1872-8081 (Electronic)
IS  - 0951-6433 (Linking)
VI  - 43
IP  - 2
DP  - 2017 Mar
TI  - Cytokine and adipokine are biofactors can act in blood and colostrum of obese
      mothers.
PG  - 243-250
LID - 10.1002/biof.1339 [doi]
AB  - Breast milk contains bioactive components that contribute to newborn development.
      However, colostrum may undergo biochemical and immunological changes as a
      function of maternal overweight and obesity. To investigate this hypothesis, this
      study determined the levels of hormones and immunological markers in the serum
      and colostrum of overweight and obese mothers. Colostrum and serum samples were
      collected from 15 normoweight, 15 overweight, and 15 obese women for
      determination of leptin, adiponectin, cytokines (TNF-alpha, IL-6, IL-10), and
      C-reactive protein (CRP). Obese mothers exhibited higher levels of serum
      TNF-alpha, IL-6, and CRP, serum and colostrum leptin and colostrum adiponectin
      and lower levels of serum adiponectin. Leptin levels in maternal serum and
      colostrum were positively correlated, as was pre-pregnancy BMI and serum
      TNF-alpha, IL-6, CRP, and leptin. Adiponectin levels in colostrum and serum were 
      negatively correlated. The results suggest that obesity changes hormonal and
      immunological components of maternal serum and colostrum. The modifications can
      have short-term and long-term effects on newborn development. (c) 2016
      BioFactors, 43(2):243-250, 2017.
CI  - (c) 2016 International Union of Biochemistry and Molecular Biology.
FAU - Fujimori, Mahmi
AU  - Fujimori M
AD  - Department of Maternal and Child Health, School of Public Health, University of
      Sao Paulo (USP), Sao Paulo, SP, Brazil.
FAU - Franca, Eduardo Luzia
AU  - Franca EL
AD  - Department of Biomedicine, Institute of Biological and Health Science - Federal
      University of Mato Grosso, Barra do Garcas, MT, Brazil.
FAU - Morais, Tassiane Cristina
AU  - Morais TC
AD  - Department of Maternal and Child Health, School of Public Health, University of
      Sao Paulo (USP), Sao Paulo, SP, Brazil.
FAU - Fiorin, Vanessa
AU  - Fiorin V
AD  - Laboratory of Scientific Writing, Department of Morphology and Physiology, School
      of Medicine of ABC, Santo Andre, SP, Brazil.
FAU - de Abreu, Luiz Carlos
AU  - de Abreu LC
AD  - Department of Maternal and Child Health, School of Public Health, University of
      Sao Paulo (USP), Sao Paulo, SP, Brazil.
AD  - Laboratory of Scientific Writing, Department of Morphology and Physiology, School
      of Medicine of ABC, Santo Andre, SP, Brazil.
FAU - Honorio-Franca, Adenilda Cristina
AU  - Honorio-Franca AC
AD  - Department of Biomedicine, Institute of Biological and Health Science - Federal
      University of Mato Grosso, Barra do Garcas, MT, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20161107
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
OTO - NOTNLM
OT  - adiponectin
OT  - cytokines
OT  - leptin
OT  - maternal obesity
EDAT- 2017/04/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/04/19 06:00
PHST- 2016/07/06 [received]
PHST- 2016/09/06 [revised]
PHST- 2016/09/16 [accepted]
AID - 10.1002/biof.1339 [doi]
PST - ppublish
SO  - Biofactors. 2017 Mar;43(2):243-250. doi: 10.1002/biof.1339. Epub 2016 Nov 7.

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