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Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report.

Abstract Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection.
PMID
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Authors

Mayor MeshTerms
Keywords

Acute disseminate encephalomyelitis

Antecedent infection

Case report

Epstein–Barr virus

Myelin oligodendrocyte glycoprotein

Transverse myelitis

Journal Title bmc neurology
Publication Year Start




PMID- 28420330
OWN - NLM
STAT- In-Process
DA  - 20170419
LR  - 20170423
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Apr 19
TI  - Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a
      primary EBV infection: a case report.
PG  - 76
LID - 10.1186/s12883-017-0858-6 [doi]
AB  - BACKGROUND: Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are
      detected in various demyelinating diseases, such as pediatric acute disseminated 
      encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4
      antibody-seronegative neuromyelitis optica spectrum disorder. We present a
      patient who developed anti-MOG antibody-positive ADEM following infectious
      mononucleosis (IM) due to Epstein-Barr virus (EBV) infection. CASE PRESENTATION: 
      A 36-year-old healthy man developed paresthesia of bilateral lower extremities
      and urinary retention 8 days after the onset of IM due to primary EBV infection. 
      The MRI revealed the lesions in the cervical spinal cord, the conus medullaris,
      and the internal capsule. An examination of the cerebrospinal fluid revealed
      pleocytosis. Cell-based immunoassays revealed positivity for anti-MOG antibody
      with a titer of 1:1024 and negativity for anti-aquaporin-4 antibody. His symptoms
      quickly improved after steroid pulse therapy followed by oral betamethasone.
      Anti-MOG antibody titer at the 6-month follow-up was negative. CONCLUSIONS: This 
      case suggests that primary EBV infection would trigger anti-MOG antibody-positive
      ADEM. Adult ADEM patients can be positive for anti-MOG antibody, the titers of
      which correlate well with the neurological symptoms.
FAU - Nakamura, Yoshitsugu
AU  - Nakamura Y
AD  - Division of Neurology, Department of Internal Medicine IV, Osaka Medical College,
      Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan. [email protected]
FAU - Nakajima, Hideto
AU  - Nakajima H
AD  - Division of Neurology, Department of Internal Medicine IV, Osaka Medical College,
      Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
FAU - Tani, Hiroki
AU  - Tani H
AD  - Division of Neurology, Department of Internal Medicine IV, Osaka Medical College,
      Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
FAU - Hosokawa, Takafumi
AU  - Hosokawa T
AD  - Division of Neurology, Department of Internal Medicine IV, Osaka Medical College,
      Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
FAU - Ishida, Shimon
AU  - Ishida S
AD  - Division of Neurology, Department of Internal Medicine IV, Osaka Medical College,
      Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
FAU - Kimura, Fumiharu
AU  - Kimura F
AD  - Division of Neurology, Department of Internal Medicine IV, Osaka Medical College,
      Daigakumachi 2-7, Takatsukishi, Osaka, 569-8686, Japan.
FAU - Kaneko, Kimihiko
AU  - Kaneko K
AD  - Division of Neurology, Tohoku University School of Medicine, Seiryomachi 1-1,
      Aobaku, Sendai, 980-8574, Japan.
FAU - Takahashi, Toshiyuki
AU  - Takahashi T
AD  - Division of Neurology, NHO Yonezawa Hospital, Ozimisawa 26100-1, Yonezawashi,
      Yamagata, 992-1202, Japan.
FAU - Nakashima, Ichiro
AU  - Nakashima I
AD  - Division of Neurology, Tohoku University School of Medicine, Seiryomachi 1-1,
      Aobaku, Sendai, 980-8574, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170419
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
PMC - PMC5395865
OTO - NOTNLM
OT  - Acute disseminate encephalomyelitis
OT  - Antecedent infection
OT  - Case report
OT  - Epstein-Barr virus
OT  - Myelin oligodendrocyte glycoprotein
OT  - Transverse myelitis
EDAT- 2017/04/20 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/12/21 [received]
PHST- 2017/04/11 [accepted]
AID - 10.1186/s12883-017-0858-6 [doi]
AID - 10.1186/s12883-017-0858-6 [pii]
PST - epublish
SO  - BMC Neurol. 2017 Apr 19;17(1):76. doi: 10.1186/s12883-017-0858-6.

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