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Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis.

Abstract Although human T-lymphotropic virus type 1 (HTLV-1) infection is a prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), specific provirus mutations in HAM/TSP have not yet been reported. In this study, we examined whether HAM/TSP patients had the disease-specific genomic variants of HTLV-1 by analyzing entire sequences of HTLV-1 proviruses in these patients, including familial cases. In addition, we investigated the genetic variants of host restriction factors conferring antiretroviral activity to determine which mutations may be related to resistance or susceptibility to HAM/TSP.
PMID
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Authors

Mayor MeshTerms

Genetic Predisposition to Disease

Genotype

Keywords

HAM/TSP

HTLV-1

TRIM5α

Transcontinental subtype

Journal Title retrovirology
Publication Year Start




PMID- 28420387
OWN - NLM
STAT- MEDLINE
DA  - 20170419
DCOM- 20170424
LR  - 20170424
IS  - 1742-4690 (Electronic)
IS  - 1742-4690 (Linking)
VI  - 14
IP  - 1
DP  - 2017 Apr 19
TI  - Effects of host restriction factors and the HTLV-1 subtype on susceptibility to
      HTLV-1-associated myelopathy/tropical spastic paraparesis.
PG  - 26
LID - 10.1186/s12977-017-0350-9 [doi]
AB  - BACKGROUND: Although human T-lymphotropic virus type 1 (HTLV-1) infection is a
      prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic
      paraparesis (HAM/TSP), specific provirus mutations in HAM/TSP have not yet been
      reported. In this study, we examined whether HAM/TSP patients had the
      disease-specific genomic variants of HTLV-1 by analyzing entire sequences of
      HTLV-1 proviruses in these patients, including familial cases. In addition, we
      investigated the genetic variants of host restriction factors conferring
      antiretroviral activity to determine which mutations may be related to resistance
      or susceptibility to HAM/TSP. RESULTS: The subjects included 30 patients with
      familial HAM/TSP (f-HAM/TSP), 92 patients with sporadic HAM/TSP (s-HAM/TSP), and 
      89 asymptomatic HTLV-1 carriers (ACs). In all 211 samples, 37 samples (18%) were 
      classified into transcontinental subtype and 174 samples (82%) were classified as
      Japanese subtype. Among three groups, the percentage of transcontinental subtype 
      in f-HAM/TSP, s-HAM/TSP and ACs was 33, 23 and 7%, respectively. The frequency of
      transcontinental subtype was significantly higher in both f-HAM/TSP (p < 0.001)
      and s-HAM/TSP (p < 0.001) than in ACs. Fifty mutations in HTLV-1 sequences were
      significantly more frequent in HAM/TSP patients than in ACs, however, they were
      common only in transcontinental subtype. Among these mutations, ten common
      mutations causing amino acid changes in the HTLV-1 sequences were specific to the
      transcontinental subtype. We examined host restriction factors, and detected a
      rare variant in TRIM5alpha in HAM/TSP patients. The patients with TRIM5alpha 136Q
      showed lower proviral loads (PVLs) than those with 136R (354 vs. 654 copies/104
      PBMC, p = 0.003). The patients with the 304L variant of TRIM5alpha had
      significantly higher PVLs than those with 304H (1669 vs. 595 copies/104 PBMC, p =
      0.025). We could not find any HAM/TSP-specific mutations of host restriction
      factors. CONCLUSIONS: Transcontinental subtype is susceptible to HAM/TSP,
      especially in familial cases. Ten common mutations causing amino acid changes in 
      the HTLV-1 gene were specific to the transcontinental subtype. TRIM5alpha
      polymorphisms were associated with PVLs, indicating that TRIM5alpha could be
      implicated in HTLV-1 replication.
FAU - Nozuma, Satoshi
AU  - Nozuma S
AD  - Department of Neurology and Geriatrics, Kagoshima University Graduate School of
      Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
FAU - Matsuura, Eiji
AU  - Matsuura E
AUID- ORCID: http://orcid.org/0000-0001-8215-8853
AD  - Department of Neurology and Geriatrics, Kagoshima University Graduate School of
      Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
      [email protected]
FAU - Kodama, Daisuke
AU  - Kodama D
AD  - Division of Molecular Pathology, Center for Chronic Viral Diseases, Kagoshima
      University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka,
      Kagoshima, 890-8520, Japan.
FAU - Tashiro, Yuichi
AU  - Tashiro Y
AD  - Department of Neurology and Geriatrics, Kagoshima University Graduate School of
      Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
FAU - Matsuzaki, Toshio
AU  - Matsuzaki T
AD  - Division of Molecular Pathology, Center for Chronic Viral Diseases, Kagoshima
      University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka,
      Kagoshima, 890-8520, Japan.
FAU - Kubota, Ryuji
AU  - Kubota R
AD  - Division of Molecular Pathology, Center for Chronic Viral Diseases, Kagoshima
      University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka,
      Kagoshima, 890-8520, Japan.
FAU - Izumo, Shuji
AU  - Izumo S
AD  - Division of Molecular Pathology, Center for Chronic Viral Diseases, Kagoshima
      University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka,
      Kagoshima, 890-8520, Japan.
FAU - Takashima, Hiroshi
AU  - Takashima H
AD  - Department of Neurology and Geriatrics, Kagoshima University Graduate School of
      Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170419
PL  - England
TA  - Retrovirology
JT  - Retrovirology
JID - 101216893
RN  - 0 (Carrier Proteins)
RN  - 0 (Immunologic Factors)
RN  - 0 (TRIM5 protein, human)
SB  - IM
MH  - Amino Acid Substitution
MH  - Carrier Proteins/*genetics
MH  - *Genetic Predisposition to Disease
MH  - *Genotype
MH  - Human T-lymphotropic virus 1/classification/*genetics/*immunology
MH  - Humans
MH  - Immunologic Factors/*genetics
MH  - Mutation
MH  - Paraparesis, Tropical Spastic/*immunology
MH  - Polymorphism, Genetic
MH  - Proviruses/genetics
MH  - Viral Load
PMC - PMC5395872
OTO - NOTNLM
OT  - HAM/TSP
OT  - HTLV-1
OT  - TRIM5alpha
OT  - Transcontinental subtype
EDAT- 2017/04/20 06:00
MHDA- 2017/04/25 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/07/18 [received]
PHST- 2017/04/10 [accepted]
AID - 10.1186/s12977-017-0350-9 [doi]
AID - 10.1186/s12977-017-0350-9 [pii]
PST - epublish
SO  - Retrovirology. 2017 Apr 19;14(1):26. doi: 10.1186/s12977-017-0350-9.

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