PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Tissue tropisms, infection kinetics, histologic lesions, and antibody response of the MR766 strain of Zika virus in a murine model.

Abstract The appearance of severe Zika virus (ZIKV) disease in the most recent outbreak has prompted researchers to respond through the development of tools to quickly characterize transmission and pathology. We describe here another such tool, a mouse model of ZIKV infection and pathogenesis using the MR766 strain of virus that adds to the growing body of knowledge regarding ZIKV kinetics in small animal models.
PMID
Related Publications

Mapping and Role of the CD8(+) T Cell Response During Primary Zika Virus Infection in Mice.

Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques.

Rescue of the 1947 Zika Virus Prototype Strain with a Cytomegalovirus Promoter-Driven cDNA Clone.

Characterization of Lethal Zika Virus Infection in AG129 Mice.

A guinea pig model of Zika virus infection.

Authors

Mayor MeshTerms
Keywords

Histology

Immunohistochemistry

Mouse model

Neutralizing antibody

Pathogenesis

Zika virus

Journal Title virology journal
Publication Year Start




PMID- 28420392
OWN - NLM
STAT- In-Process
DA  - 20170419
LR  - 20170421
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 14
IP  - 1
DP  - 2017 Apr 18
TI  - Tissue tropisms, infection kinetics, histologic lesions, and antibody response of
      the MR766 strain of Zika virus in a murine model.
PG  - 82
LID - 10.1186/s12985-017-0749-x [doi]
AB  - BACKGROUND: The appearance of severe Zika virus (ZIKV) disease in the most recent
      outbreak has prompted researchers to respond through the development of tools to 
      quickly characterize transmission and pathology. We describe here another such
      tool, a mouse model of ZIKV infection and pathogenesis using the MR766 strain of 
      virus that adds to the growing body of knowledge regarding ZIKV kinetics in small
      animal models. METHODS: We infected mice with the MR766 strain of ZIKV to
      determine infection kinetics via serum viremia. We further evaluated
      infection-induced lesions via histopathology and visualized viral antigen via
      immunohistochemical labeling. We also investigated the antibody response of
      recovered animals to both the MR766 and a strain from the current outbreak
      (PRVABC59). RESULTS: We demonstrate that the IRF3/7 DKO mouse is a susceptible,
      mostly non-lethal model well suited for the study of infection kinetics,
      pathological progression, and antibody response. Infected mice presented lesions 
      in tissues that have been associated with ZIKV infection in the human population,
      such as the eyes, male gonads, and central nervous system. In addition, we
      demonstrate that infection with the MR766 strain produces cross-neutralizing
      antibodies to the PRVABC59 strain of the Asian lineage. CONCLUSIONS: This model
      provides an additional tool for future studies into the transmission routes of
      ZIKV, as well as for the development of antivirals and other therapeutics, and
      should be included in the growing list of available tools for investigations of
      ZIKV infection and pathogenesis.
FAU - Kawiecki, Anna B
AU  - Kawiecki AB
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA, USA.
FAU - Mayton, E Handly
AU  - Mayton EH
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA, USA.
FAU - Dutuze, M Fausta
AU  - Dutuze MF
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA, USA.
FAU - Goupil, Brad A
AU  - Goupil BA
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA, USA.
FAU - Langohr, Ingeborg M
AU  - Langohr IM
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA, USA.
FAU - Del Piero, Fabio
AU  - Del Piero F
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA, USA.
FAU - Christofferson, Rebecca C
AU  - Christofferson RC
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA, USA. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170418
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
PMC - PMC5395720
OTO - NOTNLM
OT  - Histology
OT  - Immunohistochemistry
OT  - Mouse model
OT  - Neutralizing antibody
OT  - Pathogenesis
OT  - Zika virus
EDAT- 2017/04/20 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/20 06:00
PHST- 2017/02/03 [received]
PHST- 2017/04/07 [accepted]
AID - 10.1186/s12985-017-0749-x [doi]
AID - 10.1186/s12985-017-0749-x [pii]
PST - epublish
SO  - Virol J. 2017 Apr 18;14(1):82. doi: 10.1186/s12985-017-0749-x.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>