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Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study.

Abstract Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters. This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: <500 cell/mL; G2: >500 cell/mL) before (M0) and after (M1) cART initiation. We analyzed total antioxidant capacity (TAC), fat-soluble vitamins, malondialdehyde, 8-isoprostane, and DNA damage. Results. Results showed a decrease in TAC, retinol, α-tocopherol, and some carotenoids, in addition to a significant increase in DNA damage at M1. These changes were more evident in G2 subjects. Moreover, there was a significant 8-isoprostane increase at M1 in individuals belonging to G1. Conclusion. The results indicate that cART interfered in the redox system, mainly by reducing the antioxidant defenses. In addition, patients who had CD4+ T counts higher than 500 cells/mm(3) showed more susceptibility to genotoxicity, while patients with less CD4+ T counts displayed more damage triggered by lipoperoxidation. Considering the early beginning of cART, its chronic use, and its capacity to alter the redox status, further long-term studies on larger cohorts are needed to define the best time to initiate therapy and to investigate new strategies to delay the development of non-AIDS diseases.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title oxidative medicine and cellular longevity
Publication Year Start




PMID- 28421130
OWN - NLM
STAT- MEDLINE
DA  - 20170419
DCOM- 20170504
LR  - 20170504
IS  - 1942-0994 (Electronic)
IS  - 1942-0994 (Linking)
VI  - 2017
DP  - 2017
TI  - Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic
      HIV-Infected Individuals: A Longitudinal Study.
PG  - 9834803
LID - 10.1155/2017/9834803 [doi]
AB  - Background. The combination antiretroviral therapy (cART) increases the oxidative
      stress in HIV-infected people, which in turn favors the onset and aggravation of 
      non-AIDS comorbidities, a common situation affecting these individuals. We aimed 
      to evaluate the influence of cART initiation on oxidative stress parameters. This
      is a longitudinal study including 30 asymptomatic patients divided according to
      their CD4+ T cell count (G1: &lt;500 cell/mL; G2: &gt;500 cell/mL) before (M0) and
      after (M1) cART initiation. We analyzed total antioxidant capacity (TAC),
      fat-soluble vitamins, malondialdehyde, 8-isoprostane, and DNA damage. Results.
      Results showed a decrease in TAC, retinol, alpha-tocopherol, and some
      carotenoids, in addition to a significant increase in DNA damage at M1. These
      changes were more evident in G2 subjects. Moreover, there was a significant
      8-isoprostane increase at M1 in individuals belonging to G1. Conclusion. The
      results indicate that cART interfered in the redox system, mainly by reducing the
      antioxidant defenses. In addition, patients who had CD4+ T counts higher than 500
      cells/mm3 showed more susceptibility to genotoxicity, while patients with less
      CD4+ T counts displayed more damage triggered by lipoperoxidation. Considering
      the early beginning of cART, its chronic use, and its capacity to alter the redox
      status, further long-term studies on larger cohorts are needed to define the best
      time to initiate therapy and to investigate new strategies to delay the
      development of non-AIDS diseases.
FAU - Tasca, Karen Ingrid
AU  - Tasca KI
AUID- ORCID: 0000-0002-3664-3978
AD  - Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade
      Estadual Paulista (UNESP), Botucatu, SP, Brazil.
FAU - Caleffi, Juliana Trindade
AU  - Caleffi JT
AD  - Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade
      Estadual Paulista (UNESP), Botucatu, SP, Brazil.
FAU - Correa, Camila Renata
AU  - Correa CR
AUID- ORCID: 0000-0001-8493-5329
AD  - Department of Pathology, FMB, UNESP, Botucatu, SP, Brazil.
FAU - Gatto, Mariana
AU  - Gatto M
AD  - Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade
      Estadual Paulista (UNESP), Botucatu, SP, Brazil.
FAU - Tavares, Francilene Capel
AU  - Tavares FC
AD  - Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade
      Estadual Paulista (UNESP), Botucatu, SP, Brazil.
FAU - Camargo, Caio Cavassan
AU  - Camargo CC
AD  - Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade
      Estadual Paulista (UNESP), Botucatu, SP, Brazil.
FAU - Sartori, Alexandrina
AU  - Sartori A
AUID- ORCID: 0000-0003-4557-3331
AD  - Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade
      Estadual Paulista (UNESP), Botucatu, SP, Brazil.
FAU - Biasin, Mara
AU  - Biasin M
AD  - Department of Biomedical and Clinical Sciences, University of Milan, Milan,
      Italy.
FAU - de Souza, Lenice do Rosario
AU  - de Souza LDR
AD  - Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade
      Estadual Paulista (UNESP), Botucatu, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Anti-Retroviral Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - B7IN85G1HY (Dinoprost)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Adult
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Antioxidants/metabolism
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/cytology
MH  - Chromatography, High Pressure Liquid
MH  - DNA Damage
MH  - Dinoprost/analogs &amp; derivatives/analysis
MH  - Drug Therapy, Combination
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Malondialdehyde/analysis
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Reverse Transcriptase Inhibitors/therapeutic use
MH  - Young Adult
MH  - alpha-Tocopherol/metabolism
PMC - PMC5379093
EDAT- 2017/04/20 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/12/10 [received]
PHST- 2017/02/15 [revised]
PHST- 2017/02/20 [accepted]
AID - 10.1155/2017/9834803 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2017;2017:9834803. doi: 10.1155/2017/9834803. Epub 2017 Mar
      21.

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