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First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural Congenital Abnormalities Measured in Virtual Reality: An Observational Study.

Abstract Background. With the introduction of three-dimensional (3D) ultrasound it has become possible to measure volumes. The relative increase in embryonic volume (EV) is much larger than that of the crown-rump length (CRL) over the same time period. We examined whether EV is a better parameter to determine growth restriction in fetuses with structural congenital abnormalities. Study Design, Subjects, and Outcome Measures. CRL and EV were measured using a Virtual Reality (VR) system in prospectively collected 3D ultrasound volumes of 56 fetuses diagnosed with structural congenital abnormalities in the first trimester of pregnancy (gestational age 7(+5) to 14(+5) weeks). Measured CRL and EV were converted to z-scores and to percentages of the expected mean using previously published reference curves of euploid fetuses. The one-sample t-test was performed to test significance. Results. The EV was smaller than expected for GA in fetuses with structural congenital abnormalities (-35%  p < 0.001, z-score -1.44  p < 0.001), whereas CRL was not (-6.43%  p = 0.118, z-score -0.43  p = 0.605). Conclusions. CRL is a less reliable parameter to determine growth restriction in fetuses with structural congenital abnormalities as compared with EV. By measuring EV, growth restriction in first-trimester fetuses with structural congenital abnormalities becomes more evident and enables an earlier detection of these cases.
PMID
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Authors

Mayor MeshTerms

Congenital Abnormalities

Fetus

Imaging, Three-Dimensional

Pregnancy Trimester, First

Ultrasonography

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28421190
OWN - NLM
STAT- MEDLINE
DA  - 20170419
DCOM- 20170501
LR  - 20170501
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural
      Congenital Abnormalities Measured in Virtual Reality: An Observational Study.
PG  - 1953076
LID - 10.1155/2017/1953076 [doi]
AB  - Background. With the introduction of three-dimensional (3D) ultrasound it has
      become possible to measure volumes. The relative increase in embryonic volume
      (EV) is much larger than that of the crown-rump length (CRL) over the same time
      period. We examined whether EV is a better parameter to determine growth
      restriction in fetuses with structural congenital abnormalities. Study Design,
      Subjects, and Outcome Measures. CRL and EV were measured using a Virtual Reality 
      (VR) system in prospectively collected 3D ultrasound volumes of 56 fetuses
      diagnosed with structural congenital abnormalities in the first trimester of
      pregnancy (gestational age 7+5 to 14+5 weeks). Measured CRL and EV were converted
      to z-scores and to percentages of the expected mean using previously published
      reference curves of euploid fetuses. The one-sample t-test was performed to test 
      significance. Results. The EV was smaller than expected for GA in fetuses with
      structural congenital abnormalities (-35% p &lt; 0.001, z-score -1.44 p &lt; 0.001),
      whereas CRL was not (-6.43% p = 0.118, z-score -0.43 p = 0.605). Conclusions. CRL
      is a less reliable parameter to determine growth restriction in fetuses with
      structural congenital abnormalities as compared with EV. By measuring EV, growth 
      restriction in first-trimester fetuses with structural congenital abnormalities
      becomes more evident and enables an earlier detection of these cases.
FAU - Baken, L
AU  - Baken L
AUID- ORCID: 0000-0002-6980-8564
AD  - Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal
      Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam,
      Netherlands.
FAU - Benoit, B
AU  - Benoit B
AD  - Department of Obstetrics and Gynecology, Princess Grace Hospital, Monaco-Ville,
      Monaco.
FAU - Koning, A H J
AU  - Koning AHJ
AD  - Department of Bioinformatics, Erasmus MC, University Medical Center Rotterdam,
      Rotterdam, Netherlands.
FAU - van der Spek, P J
AU  - van der Spek PJ
AD  - Department of Bioinformatics, Erasmus MC, University Medical Center Rotterdam,
      Rotterdam, Netherlands.
FAU - Steegers, E A P
AU  - Steegers EAP
AD  - Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal
      Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam,
      Netherlands.
FAU - Exalto, N
AU  - Exalto N
AD  - Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal
      Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam,
      Netherlands.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170321
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Adult
MH  - *Congenital Abnormalities/diagnostic imaging
MH  - Female
MH  - Fetal Growth Retardation/*diagnostic imaging
MH  - *Fetus
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Pregnancy
MH  - *Pregnancy Trimester, First
MH  - *Ultrasonography
PMC - PMC5379074
EDAT- 2017/04/20 06:00
MHDA- 2017/05/02 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/11/16 [received]
PHST- 2017/02/08 [revised]
PHST- 2017/03/02 [accepted]
AID - 10.1155/2017/1953076 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:1953076. doi: 10.1155/2017/1953076. Epub 2017 Mar 21.

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