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Dihydromyricetin Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Mice.

Abstract Diabetic cardiomyopathy (DCM) is an important cause of heart failure in diabetic patients. The present study sought to explore the potential effects of dihydromyricetin (DHM) on DCM and its possible mechanism. A diabetic model was induced by intraperitoneal injection of streptozotocin (STZ) in C57BL/6J mice. Two weeks after the STZ injection, mice were randomly allocated into the following 4 groups for treatment: the control group (CON), the control treated with DHM group (CON + DHM), the diabetes group (DM), and the diabetes treated with DHM group (DM + DHM). DHM was dissolved in distilled water and administered daily by gavage. For 14 weeks, the CON + DHM group and DM + DHM group were given a dose of 100 mg/kg/day DHM (Sigma-Aldrich), while the CON and DM groups were intragastrically given equivalent volumes of distilled water. Assessments and comparisons were made among the groups based on cardiac function and structural changes, inflammation factors, markers of oxidative stress, mitochondria function, apoptosis, and autophagy. The DHM treatment normalized body weight, preserved cardiac function, attenuated oxidative stress (MDA, SOD, and GSH-Px), reduced the levels of inflammation factors (IL-6, TNF-α), alleviated pathological changes, improved mitochondrial function (ATP content, CS activity, and complex Ι/ΙΙ/ΙΙΙ/ΙV/V activities), inhibited cardiac apoptosis, and restored autophagy in diabetic mice. DHM may have a great therapeutic potential in the treatment of DCM.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28421194
OWN - NLM
STAT- MEDLINE
DA  - 20170419
DCOM- 20170501
LR  - 20170501
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Dihydromyricetin Protects against Diabetic Cardiomyopathy in
      Streptozotocin-Induced Diabetic Mice.
PG  - 3764370
LID - 10.1155/2017/3764370 [doi]
AB  - Diabetic cardiomyopathy (DCM) is an important cause of heart failure in diabetic 
      patients. The present study sought to explore the potential effects of
      dihydromyricetin (DHM) on DCM and its possible mechanism. A diabetic model was
      induced by intraperitoneal injection of streptozotocin (STZ) in C57BL/6J mice.
      Two weeks after the STZ injection, mice were randomly allocated into the
      following 4 groups for treatment: the control group (CON), the control treated
      with DHM group (CON + DHM), the diabetes group (DM), and the diabetes treated
      with DHM group (DM + DHM). DHM was dissolved in distilled water and administered 
      daily by gavage. For 14 weeks, the CON + DHM group and DM + DHM group were given 
      a dose of 100 mg/kg/day DHM (Sigma-Aldrich), while the CON and DM groups were
      intragastrically given equivalent volumes of distilled water. Assessments and
      comparisons were made among the groups based on cardiac function and structural
      changes, inflammation factors, markers of oxidative stress, mitochondria
      function, apoptosis, and autophagy. The DHM treatment normalized body weight,
      preserved cardiac function, attenuated oxidative stress (MDA, SOD, and GSH-Px),
      reduced the levels of inflammation factors (IL-6, TNF-alpha), alleviated
      pathological changes, improved mitochondrial function (ATP content, CS activity, 
      and complex Iota/IotaIota/IotaIotaIota/IotaV/V activities), inhibited cardiac
      apoptosis, and restored autophagy in diabetic mice. DHM may have a great
      therapeutic potential in the treatment of DCM.
FAU - Wu, Bin
AU  - Wu B
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
FAU - Lin, Jie
AU  - Lin J
AUID- ORCID: 0000-0002-0150-0264
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
FAU - Luo, Jian
AU  - Luo J
AD  - Department of Internal Medicine (VIP), The First Affiliated Hospital, Xinjiang
      Medical University, Urumqi, Xinjiang 830000, China.
FAU - Han, Dong
AU  - Han D
AUID- ORCID: 0000-0002-0545-3338
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
FAU - Fan, Miaomiao
AU  - Fan M
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
FAU - Guo, Tao
AU  - Guo T
AUID- ORCID: 0000-0003-0098-4137
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
FAU - Tao, Ling
AU  - Tao L
AUID- ORCID: 0000-0002-7076-1185
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
FAU - Yuan, Ming
AU  - Yuan M
AUID- ORCID: 0000-0002-8343-2567
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
FAU - Yi, Fu
AU  - Yi F
AUID- ORCID: 0000-0002-5500-838X
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi 710032, China.
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biomarkers)
RN  - 0 (Flavonols)
RN  - 0 (dihydromyricetin)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Autophagy/drug effects
MH  - Biomarkers/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism/pathology
MH  - Diabetic Cardiomyopathies/etiology/metabolism/pathology/*prevention & control
MH  - Flavonols/*pharmacology
MH  - Inflammation/drug therapy/metabolism/pathology
MH  - Male
MH  - Mice
MH  - Oxidative Stress/drug effects
PMC - PMC5379084
COI - The authors confirm that this paper's content has no conflict of interests.
EDAT- 2017/04/20 06:00
MHDA- 2017/05/02 06:00
CRDT- 2017/04/20 06:00
PHST- 2016/09/02 [received]
PHST- 2016/12/05 [revised]
PHST- 2016/12/13 [accepted]
AID - 10.1155/2017/3764370 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:3764370. doi: 10.1155/2017/3764370. Epub 2017 Mar 21.

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