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Teriparatide as a nonoperative treatment for tibial and femoral fracture nonunion: A case report.

Abstract Fracture nonunion is a great challenge for orthopedic surgeons. Many surgical interventions are associated with significant pain and heavy economic burden. Therefore, our aim was to evaluate the outcomes of a new nonoperative treatment for fracture nonunion.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28422848
OWN - NLM
STAT- In-Process
DA  - 20170419
LR  - 20170430
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 16
DP  - 2017 Apr
TI  - Teriparatide as a nonoperative treatment for tibial and femoral fracture
      nonunion: A case report.
PG  - e6571
LID - 10.1097/MD.0000000000006571 [doi]
AB  - RATIONALE: Fracture nonunion is a great challenge for orthopedic surgeons. Many
      surgical interventions are associated with significant pain and heavy economic
      burden. Therefore, our aim was to evaluate the outcomes of a new nonoperative
      treatment for fracture nonunion. PATIENT CONCERNS: A 44-year-old man suffered
      closed fractures of the right tibia and left femur. Eleven months after surgery, 
      there was no radiographic healing between fracture fragments. DIAGNOSES: Fracture
      nonunion of the right tibia and left femur. INTERVENTIONS: The patient received
      systemic treatment with teriparatide (recombinant human Parathyroid Hormone 1-34)
      20 mug/d for 8 months, with further observation at 4 months after
      discontinuation. During treatment, bone metabolic markers were measured to
      evaluate metabolic activity of osteoblasts and osteoclasts. The Ethics Committee 
      of Qilu Hospital of Shandong University approved this study. OUTCOMES:
      Satisfactory healing of fracture nonunion was obtained without further
      intervention. LESSONS: Anabolic treatment with teriparatide showed a positive
      effect on healing of fracture nonunion. Evaluation of bone metabolic markers
      during treatment is necessary to observe the curative effect. In view of the
      positive effect of teriparatide on healing of fracture nonunion in numerous
      animal models and clinical studies, it may be a promising alternative treatment
      for fracture nonunion in patients who are not suitable for surgical intervention.
FAU - Xiaofeng, Li
AU  - Xiaofeng L
AD  - Department of Orthopedics, Qilu Hospital of Shandong University, Ji'nan, Shandong
      Province, China.
FAU - Daxia, Xu
AU  - Daxia X
FAU - Yunzhen, Chen
AU  - Yunzhen C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
PMC - PMC5406064
EDAT- 2017/04/20 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/20 06:00
AID - 10.1097/MD.0000000000006571 [doi]
AID - 00005792-201704210-00029 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Apr;96(16):e6571. doi: 10.1097/MD.0000000000006571.

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