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Immunohistological analysis of active sacroiliitis in patients with axial spondyloarthritis.

Abstract The sacroiliac joints (SIJs) are one of the most common sites involved in axial spondyloarthritis (axSpA), and there are few studies on the histopathology of the SIJ in this group of patients.Mononuclear cell infiltrates in the bone marrow and fibrous tissue resembling a pannus formation were the pathological features of early sacroiliitis in our previous study. We undertook a further immunohistological evaluation of these features in patients with axSpA.Biopsy specimens from the SIJ of 6 patients with established ankylosing spondylitis (AS) and 13 patients with nonradiographic axial spondyloarthritis (nr-axSpA) were analyzed. An immunohistological method was performed to examine the macrophages (CD163), T cells (CD3), and B cells (CD20).Mononuclear cell infiltrates in the bone marrow were observed in only 6 patients with nr-axSpA. Fibrous tissue was observed in all patients with established AS and 9 patients with nr-axSpA. Macrophage, T cell, and B cell infiltrates could be detected in both the bone marrow and fibrous tissue. All bone marrow specimens from 6 nr-axSpA patients exhibited CD163+ macrophage infiltrates; of these, 5 exhibited CD20+ B cell infiltrates and 3 exhibited CD3+ T cell infiltrates. Among the fibrous tissue specimens, all exhibited macrophage infiltrates, 9 exhibited B cell infiltrates, and 4 exhibited T cell infiltrates.In addition to macrophages and T cells, B cells are also involved in active sacroiliitis in patients with axSpA.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28422854
OWN - NLM
STAT- MEDLINE
DA  - 20170419
DCOM- 20170509
LR  - 20170509
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 16
DP  - 2017 Apr
TI  - Immunohistological analysis of active sacroiliitis in patients with axial
      spondyloarthritis.
PG  - e6605
LID - 10.1097/MD.0000000000006605 [doi]
AB  - The sacroiliac joints (SIJs) are one of the most common sites involved in axial
      spondyloarthritis (axSpA), and there are few studies on the histopathology of the
      SIJ in this group of patients.Mononuclear cell infiltrates in the bone marrow and
      fibrous tissue resembling a pannus formation were the pathological features of
      early sacroiliitis in our previous study. We undertook a further
      immunohistological evaluation of these features in patients with axSpA.Biopsy
      specimens from the SIJ of 6 patients with established ankylosing spondylitis (AS)
      and 13 patients with nonradiographic axial spondyloarthritis (nr-axSpA) were
      analyzed. An immunohistological method was performed to examine the macrophages
      (CD163), T cells (CD3), and B cells (CD20).Mononuclear cell infiltrates in the
      bone marrow were observed in only 6 patients with nr-axSpA. Fibrous tissue was
      observed in all patients with established AS and 9 patients with nr-axSpA.
      Macrophage, T cell, and B cell infiltrates could be detected in both the bone
      marrow and fibrous tissue. All bone marrow specimens from 6 nr-axSpA patients
      exhibited CD163+ macrophage infiltrates; of these, 5 exhibited CD20+ B cell
      infiltrates and 3 exhibited CD3+ T cell infiltrates. Among the fibrous tissue
      specimens, all exhibited macrophage infiltrates, 9 exhibited B cell infiltrates, 
      and 4 exhibited T cell infiltrates.In addition to macrophages and T cells, B
      cells are also involved in active sacroiliitis in patients with axSpA.
FAU - Peng, Jianhua
AU  - Peng J
AD  - First Affiliated Hospital of Shantou University Medical College, Shantou
      University Medical College, Shantou, Guangdong Province, China.
FAU - Gong, Yao
AU  - Gong Y
FAU - Zhang, Yuping
AU  - Zhang Y
FAU - Wang, Danmin
AU  - Wang D
FAU - Xiao, Zhengyu
AU  - Xiao Z
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - B-Lymphocytes/metabolism
MH  - Bone Marrow/pathology
MH  - Child
MH  - Female
MH  - Humans
MH  - Macrophages/metabolism
MH  - Male
MH  - Middle Aged
MH  - Radiology, Interventional
MH  - Sacroiliitis/*complications/*pathology
MH  - Spondylarthritis/*complications/*pathology
MH  - T-Lymphocytes/metabolism
MH  - Young Adult
PMC - PMC5406070
EDAT- 2017/04/20 06:00
MHDA- 2017/05/10 06:00
CRDT- 2017/04/20 06:00
AID - 10.1097/MD.0000000000006605 [doi]
AID - 00005792-201704210-00035 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Apr;96(16):e6605. doi: 10.1097/MD.0000000000006605.

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