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Serum resistin positively correlates with serum lipids, but not with insulin resistance, in first-degree relatives of type-2 diabetes patients: an observational study in China.

Abstract To investigate whether serum resistin correlated with hypertension, obesity, dyslipidemia, or insulin resistance (IR) in Chinese type 2 diabetes mellitus (T2DM) patients and their first-degree relatives (DFDRs) in a case-control observational study.We determined the serum levels of resistin, plasma lipids, glucose, and insulin, and performed clinical assessments of hypertension, obesity, and IR for 42 T2DM patients, 74 of their DFDRs, and 51 healthy control participants with no family history of T2DM (NC group). The biochemical and clinical variables were compared between the 3 groups, and relationships between serum resistin and the other variables were evaluated using a Pearson correlation analysis.Significant trends were observed in the triglyceride, HbA1c, and resistin levels, in which the values observed in the DFDR group were intermediate to those of the T2DM and NC groups (P < .05 for all). A stratified analysis revealed significant trends in the resistin level and scores for homeostasis model assessment (HOMA) indexes for IR and insulin sensitivity in women and in the HbA1c and resistin levels in men (P < .05 for all), with DFDR subjects exhibiting intermediate values. The Pearson analysis showed that serum resistin positively correlated with total cholesterol and low-density lipoprotein cholesterol in the DFDR group only (P < .05 for both), and that resistin did not correlate significantly with HOMA indexes, blood glucose, insulin, HbA1c, triglyceride, high-density lipoprotein cholesterol, BMI, waist or hip circumference, or blood pressure.Our results suggest that elevated serum resistin might contribute to an increased risk of hyperlipidemia in DFDRs of Chinese T2DM patients.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28422857
OWN - NLM
STAT- In-Process
DA  - 20170419
LR  - 20170419
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 16
DP  - 2017 Apr
TI  - Serum resistin positively correlates with serum lipids, but not with insulin
      resistance, in first-degree relatives of type-2 diabetes patients: an
      observational study in China.
PG  - e6622
LID - 10.1097/MD.0000000000006622 [doi]
AB  - To investigate whether serum resistin correlated with hypertension, obesity,
      dyslipidemia, or insulin resistance (IR) in Chinese type 2 diabetes mellitus
      (T2DM) patients and their first-degree relatives (DFDRs) in a case-control
      observational study.We determined the serum levels of resistin, plasma lipids,
      glucose, and insulin, and performed clinical assessments of hypertension,
      obesity, and IR for 42 T2DM patients, 74 of their DFDRs, and 51 healthy control
      participants with no family history of T2DM (NC group). The biochemical and
      clinical variables were compared between the 3 groups, and relationships between 
      serum resistin and the other variables were evaluated using a Pearson correlation
      analysis.Significant trends were observed in the triglyceride, HbA1c, and
      resistin levels, in which the values observed in the DFDR group were intermediate
      to those of the T2DM and NC groups (P &lt; .05 for all). A stratified analysis
      revealed significant trends in the resistin level and scores for homeostasis
      model assessment (HOMA) indexes for IR and insulin sensitivity in women and in
      the HbA1c and resistin levels in men (P &lt; .05 for all), with DFDR subjects
      exhibiting intermediate values. The Pearson analysis showed that serum resistin
      positively correlated with total cholesterol and low-density lipoprotein
      cholesterol in the DFDR group only (P &lt; .05 for both), and that resistin did not 
      correlate significantly with HOMA indexes, blood glucose, insulin, HbA1c,
      triglyceride, high-density lipoprotein cholesterol, BMI, waist or hip
      circumference, or blood pressure.Our results suggest that elevated serum resistin
      might contribute to an increased risk of hyperlipidemia in DFDRs of Chinese T2DM 
      patients.
FAU - Niu, Xiao-Hong
AU  - Niu XH
AD  - aDepartment of Endocrinology bClinical Laboratory, Heji Hospital Affiliated to
      Changzhi Medical College, Changzhi, China.
FAU - Li, Li
AU  - Li L
FAU - Li, Jun-Yan
AU  - Li JY
FAU - Song, Qi
AU  - Song Q
FAU - Jin, Miao-Miao
AU  - Jin MM
FAU - Liu, Jin-Xia
AU  - Liu JX
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/04/20 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/20 06:00
AID - 10.1097/MD.0000000000006622 [doi]
AID - 00005792-201704210-00038 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Apr;96(16):e6622. doi: 10.1097/MD.0000000000006622.

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