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The levels of triglyceride and total cholesterol in methamphetamine dependence.

Abstract The serum triglyceride (TG) and total cholesterol (TC) levels have been reported altered in the traditional drug-dependence (such as marijuana and heroin). However, studies assessing the relationships among serum TC, TG, and methamphetamine (MA)-dependence have not been described well. In this study, our aim is to explore the serum TG and TC levels in large sample of MA-dependent patients. A retrospective study was conducted in 938 MA-dependent patients who were recruited between February 2, 2008 and March 11, 2013, with social characteristics and drug-dependence history (duration of MA use, routes of drug administration, and daily dose were collected). Then, the serum levels of TC, TG, glucose (GLU), body mass index (BMI), and blood pressure were measured among the participants. Meanwhile, 985 age- and gender-matched healthy people in the physical examination center were selected as control group. Compared with the control group, significant decreases of TC, TG, GLU, and BMI were observed in MA-dependent patients (P < 0.05). Besides, we found that the daily dose of MA use was associated with TC (β = -0.079, P = 0.015) and the duration of MA use was independently related to BMI (β = -0.071, P = 0.031). This study demonstrated that the levels of TC, TG, GLU, and BMI factors altered in the MA-dependent patients. In addition, there is a negative association between MA dependence and TC and BMI.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28422859
OWN - NLM
STAT- MEDLINE
DA  - 20170419
DCOM- 20170509
LR  - 20170509
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 16
DP  - 2017 Apr
TI  - The levels of triglyceride and total cholesterol in methamphetamine dependence.
PG  - e6631
LID - 10.1097/MD.0000000000006631 [doi]
AB  - The serum triglyceride (TG) and total cholesterol (TC) levels have been reported 
      altered in the traditional drug-dependence (such as marijuana and heroin).
      However, studies assessing the relationships among serum TC, TG, and
      methamphetamine (MA)-dependence have not been described well. In this study, our 
      aim is to explore the serum TG and TC levels in large sample of MA-dependent
      patients. A retrospective study was conducted in 938 MA-dependent patients who
      were recruited between February 2, 2008 and March 11, 2013, with social
      characteristics and drug-dependence history (duration of MA use, routes of drug
      administration, and daily dose were collected). Then, the serum levels of TC, TG,
      glucose (GLU), body mass index (BMI), and blood pressure were measured among the 
      participants. Meanwhile, 985 age- and gender-matched healthy people in the
      physical examination center were selected as control group. Compared with the
      control group, significant decreases of TC, TG, GLU, and BMI were observed in
      MA-dependent patients (P &lt; 0.05). Besides, we found that the daily dose of MA use
      was associated with TC (beta = -0.079, P = 0.015) and the duration of MA use was 
      independently related to BMI (beta = -0.071, P = 0.031). This study demonstrated 
      that the levels of TC, TG, GLU, and BMI factors altered in the MA-dependent
      patients. In addition, there is a negative association between MA dependence and 
      TC and BMI.
FAU - Zhang, Meijuan
AU  - Zhang M
AD  - aDepartment of Clinical Laboratory bDepartment of Neurology, The First Affiliated
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Lv, Dezhao
AU  - Lv D
FAU - Zhou, Wu
AU  - Zhou W
FAU - Ji, Lili
AU  - Ji L
FAU - Zhou, Beibei
AU  - Zhou B
FAU - Chen, Han
AU  - Chen H
FAU - Gu, Yingying
AU  - Gu Y
FAU - Zhao, Jiyun
AU  - Zhao J
FAU - He, Jincai
AU  - He J
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamine-Related Disorders/*blood
MH  - Blood Glucose
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Cholesterol/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Socioeconomic Factors
MH  - Triglycerides/*blood
MH  - Young Adult
PMC - PMC5406075
EDAT- 2017/04/20 06:00
MHDA- 2017/05/10 06:00
CRDT- 2017/04/20 06:00
AID - 10.1097/MD.0000000000006631 [doi]
AID - 00005792-201704210-00040 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Apr;96(16):e6631. doi: 10.1097/MD.0000000000006631.

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