PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Crystalglobulinemia manifesting as chronic arthralgia and acute limb ischemia: A clinical case report.

Abstract Crystalglobulinemia is a rare disease caused by monoclonal immunoglobulins, characterized by irreversible crystallization on refrigeration. It causes systemic symptoms including purpura, arthralgia, and vessel occlusive conditions to be exacerbated by exposure to cold. We report a patient with crystalglobulinemia associated with monoclonal gammopathy of undetermined significance (MGUS) manifesting as chronic arthralgia and recurrent acute arterial occlusion.
PMID
Related Publications

Long-term follow-up of patients with monoclonal gammopathy of undetermined significance after kidney transplantation.

Crystalglobulinemia with fulminant course with cylinder-like bodies on peripheral blood smear.

Monoclonal gammopathy of undetermined significance and asymptomatic multiple myelom in the year 2014 .

Fatal Cryocrystalglobulinemia With Intravascular and Renal Tubular Crystalline Deposits.

Laminar crystal deposition in large vessels in a patient with crystalglobulinemia.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28422865
OWN - NLM
STAT- In-Process
DA  - 20170419
LR  - 20170419
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 16
DP  - 2017 Apr
TI  - Crystalglobulinemia manifesting as chronic arthralgia and acute limb ischemia: A 
      clinical case report.
PG  - e6643
LID - 10.1097/MD.0000000000006643 [doi]
AB  - RATIONALE: Crystalglobulinemia is a rare disease caused by monoclonal
      immunoglobulins, characterized by irreversible crystallization on refrigeration. 
      It causes systemic symptoms including purpura, arthralgia, and vessel occlusive
      conditions to be exacerbated by exposure to cold. We report a patient with
      crystalglobulinemia associated with monoclonal gammopathy of undetermined
      significance (MGUS) manifesting as chronic arthralgia and recurrent acute
      arterial occlusion. PRESENTING CONCERNS: A 61-year-old man, who had been
      diagnosed with MGUS and who had arthralgia of unknown origin, presented with
      recurrent acute limb ischemia after surgical thromboembolectomy. Refrigeration of
      his serum formed precipitates that looked like needle-shaped crystals. These
      crystals did not dissolve with warming, which is not a characteristic of
      cryoglobulins. Skin biopsy results showed crystal-liked eosinophilic bodies in
      small vessels and we diagnosed crystalglobulinemia. INTERVENTION AND OUTCOMES:
      Although he underwent above-knee amputation, he was treated with a bortezomib and
      dexamethasone-based chemotherapeutic regimen, following lenalidomide maintenance 
      therapy. Finally, he achieved complete remission and serum crystalglobulins
      diminished. LESSONS: Monoclonal gammopathy, previously diagnosed as MGUS, can
      cause systemic symptoms and thrombotic conditions by producing pathologic
      immunoglobulins, such as crystalglobulins. In such situations, MGUS, even when it
      has not progressed to multiple myeloma, can be a target of aggressive
      chemotherapy. Crystalglobulinemia should be considered for patients with
      monoclonal gammopathy manifesting as systemic and thrombotic symptoms exacerbated
      by cooling.
FAU - Abe, Nobuya
AU  - Abe N
AD  - Department of Rheumatology, NTT Sapporo Medical Center, Sapporo, Japan.
FAU - Tomita, Tomoko
AU  - Tomita T
FAU - Bohgaki, Miyuki
AU  - Bohgaki M
FAU - Kasahara, Hideki
AU  - Kasahara H
FAU - Koike, Takao
AU  - Koike T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/04/20 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/20 06:00
AID - 10.1097/MD.0000000000006643 [doi]
AID - 00005792-201704210-00046 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Apr;96(16):e6643. doi: 10.1097/MD.0000000000006643.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>