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Metabolic syndrome, serum uric acid and renal risk in patients with T2D.

Abstract Metabolic Syndrome (Mets) and increased serum uric acid (SUA), are well known renal risk predictors and often coexist in patients with type 2 diabetes (T2D). Whether they independently contribute to the onset of CKD is at present unclear.
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Publication Year Start




PMID- 28423036
OWN - NLM
STAT- In-Process
DA  - 20170419
LR  - 20170419
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Metabolic syndrome, serum uric acid and renal risk in patients with T2D.
PG  - e0176058
LID - 10.1371/journal.pone.0176058 [doi]
AB  - BACKGROUND AND AIMS: Metabolic Syndrome (Mets) and increased serum uric acid
      (SUA), are well known renal risk predictors and often coexist in patients with
      type 2 diabetes (T2D). Whether they independently contribute to the onset of CKD 
      is at present unclear. METHODS AND RESULTS: Within the AMD Annals database we
      identified patients with T2D and normal renal function and urine albumin
      excretion at baseline and regular follow-up visits during a 4-year period. Blood 
      pressure, BMI, HDL, triglycerides, and SUA were available in 14,267 patients. The
      association between Mets and/or hyperuricemia (HU, top fifth gender specific
      quintile) and the occurrence of renal outcomes were evaluated. RESULTS: At
      baseline 59% of patients (n = 8,408) showed Mets and 18% (n = 2,584) HU. Over the
      4-year follow-up, 14% (n = 1,990) developed low eGFR (i.e. below 60 mL/min/1.73
      m2), and 26% (n = 3,740) albuminuria. After adjustment for confounders,
      BP>/=130/85, low HDL, triglycerides >/=150 and HU were independently related to
      the development of low eGFR (1.57, P<0.001; 1.13, P = 0.056; 1.18, P = 0.008;
      1.26, P = 0.001) and of albuminuria (1.35, P<0.001; 1.18, P = 0.001; 1.15, P =
      0.002; 1.24, P = 0.001), respectively. The incidence of low eGFR was higher in
      patients with HU independent of the presence or absence of Mets (21%, OR 1.30, p 
      = 0.009 and 20%, 1.57, p<0.000 respectively), while albuminuria occurred more
      frequently in those with Mets and HU (32%, OR 1.25, p = 0.005) as compared to the
      reference group. CONCLUSIONS: HU and Mets are independent predictors of CKD and
      its individual components in patients with T2D.
FAU - Viazzi, Francesca
AU  - Viazzi F
AUID- ORCID: http://orcid.org/0000-0003-4219-7043
AD  - Universita degli Studi and IRCCS Azienda Ospedaliera Universitaria San
      Martino-IST, Genova, Italy.
FAU - Piscitelli, Pamela
AU  - Piscitelli P
AD  - Department of Medical Sciences, Scientific Institute "Casa Sollievo della
      Sofferenza", San Giovanni Rotondo (FG), Italy.
FAU - Giorda, Carlo
AU  - Giorda C
AD  - Diabetes and Metabolism Unit, ASL Turin 5, Chieri (TO), Italy.
FAU - Ceriello, Antonio
AU  - Ceriello A
AD  - Institut d'Investigacions Biomediques August Pii Sunyer (IDIBAPS) and Centro de
      Investigacion Biomedicaen Red de Diabetes y Enfermedades Metabolicas Asociadas
      (CIBERDEM), Barcelona, Spain.
AD  - Department of Cardiovascular and Metabolic Diseases, IRCCS Gruppo Multimedica,
      Sesto San Giovanni, Milano, Italy.
FAU - Genovese, Stefano
AU  - Genovese S
AD  - Department of Cardiovascular and Metabolic Diseases, IRCCS Gruppo Multimedica,
      Sesto San Giovanni, Milano, Italy.
FAU - Russo, Giuseppina
AU  - Russo G
AD  - Department of Clinical and Experimental Medicine, University of Messina, Messina,
      Italy.
FAU - Guida, Pietro
AU  - Guida P
AD  - Associazione Medici Diabetologi, Rome, Italy.
FAU - Fioretto, Paola
AU  - Fioretto P
AD  - Department of Medicine, University of Padua, Padova, Italy.
FAU - De Cosmo, Salvatore
AU  - De Cosmo S
AD  - Department of Medical Sciences, Scientific Institute "Casa Sollievo della
      Sofferenza", San Giovanni Rotondo (FG), Italy.
FAU - Pontremoli, Roberto
AU  - Pontremoli R
AD  - Universita degli Studi and IRCCS Azienda Ospedaliera Universitaria San
      Martino-IST, Genova, Italy.
CN  - AMD-Annals Study Group
LA  - eng
PT  - Journal Article
DEP - 20170419
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
EDAT- 2017/04/20 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/04/20 06:00
PHST- 2017/01/25 [received]
PHST- 2017/04/04 [accepted]
AID - 10.1371/journal.pone.0176058 [doi]
AID - PONE-D-17-03377 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 19;12(4):e0176058. doi: 10.1371/journal.pone.0176058.
      eCollection 2017.

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