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Clinical Significance of Preoperative Albumin and Globulin Ratio in Patients with Gastric Cancer Undergoing Treatment.

Abstract Background. The pretreatment albumin and globulin ratio (AGR) was an inflammation-associated factor which was related to the overall survival in various malignancies. The aim of this study was to evaluate the prognostic value of AGR in patients with gastric cancer. Method. This retrospective study included 862 cases pathologically diagnosed with gastric cancer. All patients were randomly divided into the testing group (431 cases) and validation group (431 cases). The relationships of AGR with clinicopathologic characteristics and prognosis were analyzed by Kaplan-Meier and Cox regression methods. Results. In the testing group, the median overall survival was 26.90 months and the cutoff value of AGR was 1.50 based on R language. Kaplan-Meier analysis showed that lower AGR was correlated with poorer overall survival. Multivariate analysis demonstrated that AGR was an independent prognostic factor for overall survival (HR: 0.584, 95% CI = 0.351-0.973, and p = 0.039). In the validation group, the median overall survival was 24.10 months. Lower AGR (≤1.50) also had a significantly poorer overall survival by Kaplan-Meier analysis. According to multivariate analysis, the AGR was also confirmed to be an independent prognostic factor for overall survival (HR: 0.578, 95% CI = 0.373-0.897, and p = 0.015). Conclusions. Our study suggested that the pretreatment AGR could be a prognostic biomarker for overall survival in patients with gastric cancer.
PMID
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Authors

Mayor MeshTerms

Preoperative Care

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28424782
OWN - NLM
STAT- MEDLINE
DA  - 20170420
DCOM- 20170508
LR  - 20170508
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Clinical Significance of Preoperative Albumin and Globulin Ratio in Patients with
      Gastric Cancer Undergoing Treatment.
PG  - 3083267
LID - 10.1155/2017/3083267 [doi]
AB  - Background. The pretreatment albumin and globulin ratio (AGR) was an
      inflammation-associated factor which was related to the overall survival in
      various malignancies. The aim of this study was to evaluate the prognostic value 
      of AGR in patients with gastric cancer. Method. This retrospective study included
      862 cases pathologically diagnosed with gastric cancer. All patients were
      randomly divided into the testing group (431 cases) and validation group (431
      cases). The relationships of AGR with clinicopathologic characteristics and
      prognosis were analyzed by Kaplan-Meier and Cox regression methods. Results. In
      the testing group, the median overall survival was 26.90 months and the cutoff
      value of AGR was 1.50 based on R language. Kaplan-Meier analysis showed that
      lower AGR was correlated with poorer overall survival. Multivariate analysis
      demonstrated that AGR was an independent prognostic factor for overall survival
      (HR: 0.584, 95% CI = 0.351-0.973, and p = 0.039). In the validation group, the
      median overall survival was 24.10 months. Lower AGR (</=1.50) also had a
      significantly poorer overall survival by Kaplan-Meier analysis. According to
      multivariate analysis, the AGR was also confirmed to be an independent prognostic
      factor for overall survival (HR: 0.578, 95% CI = 0.373-0.897, and p = 0.015).
      Conclusions. Our study suggested that the pretreatment AGR could be a prognostic 
      biomarker for overall survival in patients with gastric cancer.
FAU - Mao, Min-Jie
AU  - Mao MJ
AD  - Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
FAU - Wei, Xiao-Li
AU  - Wei XL
AD  - Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key
      Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer
      Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060, China.
FAU - Sheng, Hui
AU  - Sheng H
AD  - Department of Experimental Research, Sun Yat-sen University Cancer Center, State 
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
FAU - Wang, Xue-Ping
AU  - Wang XP
AD  - Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
FAU - Li, Xiao-Hui
AU  - Li XH
AD  - Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
FAU - Liu, Yi-Jun
AU  - Liu YJ
AD  - Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
FAU - Xing, Shan
AU  - Xing S
AD  - Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
FAU - Huang, Qi
AU  - Huang Q
AD  - Guangdong Medical University, 1 Xin Cheng Road, Songshan Hu, Dongguan, Guangdong 
      Province 523808, China.
FAU - Dai, Shu-Qin
AU  - Dai SQ
AUID- ORCID: 0000-0003-2586-6989
AD  - Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
FAU - Liu, Wan-Li
AU  - Liu WL
AUID- ORCID: 0000-0002-2358-5182
AD  - Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State
      Key Laboratory of Oncology in South China, Collaborative Innovation Center for
      Cancer Medicine, 651 Dong Feng Road East, Guangzhou, Guangdong Province 510060,
      China.
LA  - eng
PT  - Journal Article
DEP - 20170323
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Globulins)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Female
MH  - Globulins/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Preoperative Care
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Serum Albumin/*metabolism
MH  - Stomach Neoplasms/*blood/pathology/*surgery
PMC - PMC5382292
EDAT- 2017/04/21 06:00
MHDA- 2017/05/10 06:00
CRDT- 2017/04/21 06:00
PHST- 2016/12/13 [received]
PHST- 2017/03/08 [revised]
PHST- 2017/03/13 [accepted]
AID - 10.1155/2017/3083267 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:3083267. doi: 10.1155/2017/3083267. Epub 2017 Mar 23.

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