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The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke.

Abstract We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p < 0.05), B12 level (r = -0.410, p < 0.01), and vitamin D levels (r = -0.465, p < 0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28424785
OWN - NLM
STAT- In-Process
DA  - 20170420
LR  - 20170423
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional
      Outcome after First-Ever Ischaemic Stroke.
PG  - 5489057
LID - 10.1155/2017/5489057 [doi]
AB  - We explored the relationship between acute ischaemic stroke (IS) early functional
      outcome and serum levels of homocysteine, vitamin B12, and D in a
      noninterventional prospective clinical study. We enrolled 50 patients with
      first-ever IS and performed laboratory tests and functional assessment at three
      time points: on admission and three and six months after stroke. Modified Rankin 
      Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all
      participants by trained examiner blinded to laboratory data. Patients did not
      receive treatment that might alter laboratory data. Admission NIHSS correlated
      with homocysteine levels (r = 0.304, p &lt; 0.05), B12 level (r = -0.410, p &lt; 0.01),
      and vitamin D levels (r = -0.465, p &lt; 0.01). Functional outcome measures (BI and 
      mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3
      and 6 months. However, a positive correlation with vitamin B12 levels was
      detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin 
      B12 levels were associated with better functional outcome at follow-up.
FAU - Markisic, Merdin
AU  - Markisic M
AD  - General Hospital, Unit of Neurology, Svetog Save Street No. 33, Berane,
      Montenegro.
FAU - Pavlovic, Aleksandra M
AU  - Pavlovic AM
AD  - Faculty of Medicine, University of Belgrade, Neurology Clinic, Clinical Center of
      Serbia, Dr. Subotica Street No. 6, 11 000 Belgrade, Serbia.
FAU - Pavlovic, Dragan M
AU  - Pavlovic DM
AUID- ORCID: 0000-0001-6054-6572
AD  - Faculty for Special Education and Rehabilitation, University of Belgrade, Visokog
      Stevana Street No. 2, 11 000 Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20170323
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
PMC - PMC5382296
EDAT- 2017/04/21 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/21 06:00
PHST- 2017/01/11 [received]
PHST- 2017/03/04 [revised]
PHST- 2017/03/09 [accepted]
AID - 10.1155/2017/5489057 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:5489057. doi: 10.1155/2017/5489057. Epub 2017 Mar 23.

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