PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

LincRNa-p21: function and mechanism in cancer.

Abstract In view of the rapid development of gene chips and high-throughput sequencing technology, noncoding RNAs (ncRNas) form a high percentage of the mammalian genome. Two major subgroups of ncRNAs that have been identified are the long ncRNAs (lncRNas) and the microRNAs. A number of studies in the past few years have showed crucial functions for lncRNas in cancer. LincRNa-p21 as a p53-dependent transcriptional target gene and a potential diagnostic marker is involved in proliferation, cell cycle, metabolism and reprogramming. In addition, more researches revealed that lincRNa-p21 is associated with cancer progression and contributed to the treatment and prognosis of cancer. In this review, we briefly summarize the function and molecular mechanisms of lincRNa-p21 in cancer and its regulation for the genes expression .
PMID
Related Publications

The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.

Long intragenic non-coding RNA lincRNA-p21 suppresses development of human prostate cancer.

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.

LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity.

LincRNA-p21: Implications in Human Diseases.

Authors

Mayor MeshTerms
Keywords

Cancer

Genes expression

LincRNa-p21

Long noncoding RNAs

Journal Title medical oncology (northwood, london, england)
Publication Year Start




PMID- 28425074
OWN - NLM
STAT- In-Process
DA  - 20170420
LR  - 20170420
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 34
IP  - 5
DP  - 2017 May
TI  - LincRNa-p21: function and mechanism in cancer.
PG  - 98
LID - 10.1007/s12032-017-0959-5 [doi]
AB  - In view of the rapid development of gene chips and high-throughput sequencing
      technology, noncoding RNAs (ncRNas) form a high percentage of the mammalian
      genome. Two major subgroups of ncRNAs that have been identified are the long
      ncRNAs (lncRNas) and the microRNAs. A number of studies in the past few years
      have showed crucial functions for lncRNas in cancer. LincRNa-p21 as a
      p53-dependent transcriptional target gene and a potential diagnostic marker is
      involved in proliferation, cell cycle, metabolism and reprogramming. In addition,
      more researches revealed that lincRNa-p21 is associated with cancer progression
      and contributed to the treatment and prognosis of cancer. In this review, we
      briefly summarize the function and molecular mechanisms of lincRNa-p21 in cancer 
      and its regulation for the genes expression .
FAU - Chen, Shaoyun
AU  - Chen S
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Liang, Hairong
AU  - Liang H
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Yang, Hui
AU  - Yang H
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Zhou, Kairu
AU  - Zhou K
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Xu, Longmei
AU  - Xu L
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Liu, Jiaxian
AU  - Liu J
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Lai, Bei
AU  - Lai B
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Song, Li
AU  - Song L
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Luo, Hao
AU  - Luo H
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China.
FAU - Peng, Jianming
AU  - Peng J
AD  - Huizhou Prevention and Treatment Centre for Occupational Disease, Huizhou,
      516000, China.
FAU - Liu, Zhidong
AU  - Liu Z
AD  - Huizhou Prevention and Treatment Centre for Occupational Disease, Huizhou,
      516000, China.
FAU - Xiao, Yongmei
AU  - Xiao Y
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment,
      Department of Toxicology, School of Public Health, Sun Yat-sen University,
      Guangzhou, 510080, China.
FAU - Chen, Wen
AU  - Chen W
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment,
      Department of Toxicology, School of Public Health, Sun Yat-sen University,
      Guangzhou, 510080, China.
FAU - Tang, Huanwen
AU  - Tang H
AD  - Department of Environmental and Occupational Health, Dongguan Key Laboratory of
      Environmental Medicine, School of Public Health, Guangdong Medical University,
      Dongguan, 523808, China. [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170419
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
OTO - NOTNLM
OT  - Cancer
OT  - Genes expression
OT  - LincRNa-p21
OT  - Long noncoding RNAs
EDAT- 2017/04/21 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/21 06:00
PHST- 2017/03/28 [received]
PHST- 2017/04/12 [accepted]
AID - 10.1007/s12032-017-0959-5 [doi]
AID - 10.1007/s12032-017-0959-5 [pii]
PST - ppublish
SO  - Med Oncol. 2017 May;34(5):98. doi: 10.1007/s12032-017-0959-5. Epub 2017 Apr 19.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>