OWN - NLM
DA - 20170420
LR - 20170420
IS - 1365-2796 (Electronic)
IS - 0954-6820 (Linking)
VI - 281
IP - 5
DP - 2017 May
TI - Eosinophilic esophagitis: unclear roles of IgE and eosinophils.
PG - 448-457
LID - 10.1111/joim.12568 [doi]
AB - Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the
oesophagus. Recognized as a distinct entity only two decades ago, the emergence
of the disease along with the availability of new technologies has rapidly opened
new research avenues and outlined the main features of the pathogenesis of EoE.
Yet, each advance in our understanding of the disease has raised new questions
about the previous consensus. Currently, new subsets of the disease challenge our
diagnostic criteria. For instance, it was believed that EoE did not respond to
proton pump inhibitor (PPI) therapy; however, it has now been shown that a
substantial proportion of EoE patients indeed respond to PPIs. In addition, a new
subset of patients not even presenting eosinophil infiltrates in the oesophagus
has also been described. Moreover, approaches for better understanding the
heritability of the disease bring into question the dogma of predominant genetic
involvement. Furthermore, the specificity and sensitivity of allergy testing for
targeted food avoidance is highly controversial, and the production of specific
antibodies in EoE now includes IgG4 in addition to IgE. In conclusion, EoE is
perceived as 'a moving target' and the aim of this review was to summarize the
current understanding of EoE pathogenesis.
CI - (c) 2016 The Association for the Publication of the Journal of Internal Medicine.
FAU - Blanchard, C
AU - Blanchard C
AD - Nestle Research Center, Lausanne, Switzerland.
FAU - Simon, D
AU - Simon D
AD - Department of Dermatology, Inselspital, Bern University Hospital, Bern,
FAU - Schoepfer, A
AU - Schoepfer A
AD - Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois (CHUV),
FAU - Straumann, A
AU - Straumann A
AD - Swiss EoE Clinic and EoE Research Network, Olten, Switzerland.
FAU - Simon, H-U
AU - Simon HU
AD - Institute of Pharmacology, University of Bern, Bern, Switzerland.
LA - eng
PT - Journal Article
DEP - 20161107
PL - England
TA - J Intern Med
JT - Journal of internal medicine
JID - 8904841
OTO - NOTNLM
OT - Eosinophilic esophagitis
OT - eosinophils
OT - immunoglobulin E
OT - pathogenesis
EDAT- 2017/04/21 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/21 06:00
AID - 10.1111/joim.12568 [doi]
PST - ppublish
SO - J Intern Med. 2017 May;281(5):448-457. doi: 10.1111/joim.12568. Epub 2016 Nov 7.