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Bacterial screening of platelet components by National Health Service Blood and Transplant, an effective risk reduction measure.

Abstract Bacterial contamination of blood components remains a major cause of sepsis in transfusion medicine. Between 2006 and 2010 in the 5 years before the introduction of bacterial screening of platelet (PLT) components by National Health Service Blood and Transplant (NHSBT), seven cases of PLT component-associated transmission of bacterial infection were recorded for 10 patients, three of which were fatal.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title transfusion
Publication Year Start




PMID- 28425610
OWN - NLM
STAT- MEDLINE
DA  - 20170420
DCOM- 20170504
LR  - 20170504
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 57
IP  - 5
DP  - 2017 May
TI  - Bacterial screening of platelet components by National Health Service Blood and
      Transplant, an effective risk reduction measure.
PG  - 1122-1131
LID - 10.1111/trf.14085 [doi]
AB  - BACKGROUND: Bacterial contamination of blood components remains a major cause of 
      sepsis in transfusion medicine. Between 2006 and 2010 in the 5 years before the
      introduction of bacterial screening of platelet (PLT) components by National
      Health Service Blood and Transplant (NHSBT), seven cases of PLT
      component-associated transmission of bacterial infection were recorded for 10
      patients, three of which were fatal. STUDY DESIGN AND METHODS: Sampling of
      individual PLT components was undertaken at 36 to 48 hours after donation and
      tested in the BacT/ALERT system with 8 mL inoculated into each of aerobic and
      anaerobic culture bottles. Bottles were incubated until the end of the 7-day
      shelf life and initial reactive bottles were examined for contamination.
      Bacterial screened time-expired PLTs were tested as in the screen method.
      RESULTS: From February 2011 to September 2015, a total of 1,239,029 PLT
      components were screened. Initial-reactive, confirmed-positive, and
      false-positive rates were 0.37, 0.03, and 0.19%, respectively. False-negative
      cultures, all with Staphylococcus aureus, occurred on four occasions; three were 
      visually detected before transfusion and one confirmed transmission resulted in
      patient morbidity. The NHSBT screening protocol effectively reduced the number of
      clinically adverse transfusion transmissions by 90% in this reporting period,
      compared to a similar time period before implementation. Delayed testing of 4515 
      time-expired PLT units after screening revealed no positives. CONCLUSION: The
      implementation of bacterial screening of PLT components with the NHSBT BacT/ALERT
      protocol was an effective risk reduction measure and increased the safety of the 
      blood supply.
CI  - (c) 2017 AABB.
FAU - McDonald, Carl
AU  - McDonald C
AD  - NHS Blood and Transplant, London, UK.
FAU - Allen, Jennifer
AU  - Allen J
AD  - NHS Blood and Transplant, London, UK.
FAU - Brailsford, Susan
AU  - Brailsford S
AD  - NHS Blood and Transplant, London, UK.
FAU - Roy, Anjana
AU  - Roy A
AD  - NHS Blood and Transplant, London, UK.
FAU - Ball, Joanne
AU  - Ball J
AD  - NHS Blood and Transplant, London, UK.
FAU - Moule, Richard
AU  - Moule R
AD  - NHS Blood and Transplant, London, UK.
FAU - Vasconcelos, Mariza
AU  - Vasconcelos M
AD  - NHS Blood and Transplant, London, UK.
FAU - Morrison, Rachael
AU  - Morrison R
AD  - NHS Blood and Transplant, London, UK.
FAU - Pitt, Tyrone
AU  - Pitt T
AD  - NHS Blood and Transplant, London, UK.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
MH  - Bacterial Infections/*prevention & control/transmission
MH  - Bacteriological Techniques/methods
MH  - Blood Banks/methods
MH  - Blood Platelets/*microbiology
MH  - Humans
MH  - National Health Programs
MH  - Platelet Transfusion/*adverse effects
MH  - Plateletpheresis/standards
MH  - Risk Reduction Behavior
MH  - Staphylococcus aureus/isolation & purification
MH  - Time Factors
EDAT- 2017/04/21 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/04/21 06:00
PHST- 2016/07/18 [received]
PHST- 2017/01/19 [revised]
PHST- 2017/01/19 [accepted]
AID - 10.1111/trf.14085 [doi]
PST - ppublish
SO  - Transfusion. 2017 May;57(5):1122-1131. doi: 10.1111/trf.14085.

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