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Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

Abstract To determine the incidence rates of sudden unexpected death in epilepsy (SUDEP) in different epilepsy populations and address the question of whether risk factors for SUDEP have been identified.
PMID
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Authors

Mayor MeshTerms

Death, Sudden

Keywords
Journal Title neurology
Publication Year Start




PMID- 28438841
OWN - NLM
STAT- MEDLINE
DA  - 20170425
DCOM- 20170515
LR  - 20170515
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 88
IP  - 17
DP  - 2017 Apr 25
TI  - Practice guideline summary: Sudden unexpected death in epilepsy incidence rates
      and risk factors: Report of the Guideline Development, Dissemination, and
      Implementation Subcommittee of the American Academy of Neurology and the American
      Epilepsy Society.
PG  - 1674-1680
LID - 10.1212/WNL.0000000000003685 [doi]
AB  - OBJECTIVE: To determine the incidence rates of sudden unexpected death in
      epilepsy (SUDEP) in different epilepsy populations and address the question of
      whether risk factors for SUDEP have been identified. METHODS: Systematic review
      of evidence; modified Grading Recommendations Assessment, Development, and
      Evaluation process for developing conclusions; recommendations developed by
      consensus. RESULTS: Findings for incidence rates based on 12 Class I studies
      include the following: SUDEP risk in children with epilepsy (aged 0-17 years) is 
      0.22/1,000 patient-years (95% confidence interval [CI] 0.16-0.31) (moderate
      confidence in evidence). SUDEP risk increases in adults to 1.2/1,000
      patient-years (95% CI 0.64-2.32) (low confidence in evidence). The major risk
      factor for SUDEP is the occurrence of generalized tonic-clonic seizures (GTCS);
      the SUDEP risk increases in association with increasing frequency of GTCS
      occurrence (high confidence in evidence). RECOMMENDATIONS: Level B: Clinicians
      caring for young children with epilepsy should inform parents/guardians that in 1
      year, SUDEP typically affects 1 in 4,500 children; therefore, 4,499 of 4,500
      children will not be affected. Clinicians should inform adult patients with
      epilepsy that SUDEP typically affects 1 in 1,000 adults with epilepsy per year;
      therefore, annually 999 of 1,000 adults will not be affected. For persons with
      epilepsy who continue to experience GTCS, clinicians should continue to actively 
      manage epilepsy therapies to reduce seizures and SUDEP risk while incorporating
      patient preferences and weighing the risks and benefits of any new approach.
      Clinicians should inform persons with epilepsy that seizure freedom, particularly
      freedom from GTCS, is strongly associated with decreased SUDEP risk.
CI  - (c) 2017 American Academy of Neurology.
FAU - Harden, Cynthia
AU  - Harden C
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Tomson, Torbjorn
AU  - Tomson T
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Gloss, David
AU  - Gloss D
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Buchhalter, Jeffrey
AU  - Buchhalter J
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Cross, J Helen
AU  - Cross JH
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Donner, Elizabeth
AU  - Donner E
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - French, Jacqueline A
AU  - French JA
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Gil-Nagel, Anthony
AU  - Gil-Nagel A
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Hesdorffer, Dale C
AU  - Hesdorffer DC
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Smithson, W Henry
AU  - Smithson WH
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Spitz, Mark C
AU  - Spitz MC
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Walczak, Thaddeus S
AU  - Walczak TS
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Sander, Josemir W
AU  - Sander JW
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
FAU - Ryvlin, Philippe
AU  - Ryvlin P
AD  - From the Department of Neurology (C.H.), Mount Sinai Health System, New York, NY;
      Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm,
      Sweden; Department of Neurology (D.G.), CAMC Physicians, Charleston, WV;
      Departments of Pediatrics and Clinical Neurosciences (J.B.), Alberta Children's
      Hospital, University of Calgary, Canada; Department of Clinical Neurosciences,
      Institute of Child Health (J.H.C.), and Institute of Neurology (J.W.S.),
      University College London; Great Ormond Street Hospital for Children NHS
      Foundation Trust (J.H.C.), London, UK; Department of Paediatrics (E.D.), Division
      of Neurology, The Hospital for Sick Children, University of Toronto, Canada;
      Department of Neurology (J.A.F.), New York University Langone Comprehensive
      Epilepsy Center, New York; Department of Neurology (A.G.-N.), Hospital Ruber
      Internacional, Madrid, Spain; Gertrude H. Sergievsky Center and Department of
      Epidemiology (D.C.H.), Columbia University Medical Center, New York, NY;
      Department of General Practice (W.H.S.), University College Cork, Ireland;
      Anschutz Outpatient Pavilion (M.C.S.), University of Colorado Health, Aurora;
      Neurology Clinic (T.S.W.), University of Minnesota, Minneapolis; Stichting
      Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands; and
      the Department of Clinical Neurosciences (P.R.), CHUV, Lausanne, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - AIM
SB  - IM
MH  - *Death, Sudden/prevention & control
MH  - Epilepsy/*mortality/therapy
MH  - Humans
MH  - Incidence
MH  - Risk Factors
EDAT- 2017/04/26 06:00
MHDA- 2017/05/16 06:00
CRDT- 2017/04/26 06:00
PHST- 2016/06/24 [received]
PHST- 2016/11/02 [accepted]
AID - WNL.0000000000003685 [pii]
AID - 10.1212/WNL.0000000000003685 [doi]
PST - ppublish
SO  - Neurology. 2017 Apr 25;88(17):1674-1680. doi: 10.1212/WNL.0000000000003685.

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