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Comparing the curative efficacy of topical treatment with thiamphenicol and oxytetracycline on digital dermatitis lesions in dairy cattle.

Abstract The efficacy of two topically applied antibiotics for the treatment of painful ulcerative stage of bovine digital dermatitis (BDD) lesions was compared in a clinical trial conducted on five dairy farms in the Netherlands during the autumn of 2015. A total of 109 cows with an ulcerative (M2) stage of BDD were randomly appointed a treatment with an antibiotic-based spray. One treatment contained thiamphenicol as active ingredient (TAF). The other treatment had oxytetracycline as active ingredient (ENG). The experimental unit for this study was the hind claw with the presence of an ulcerative BDD lesion. On day 0, claws with ulcerative BDD lesions were trimmed, cleaned, photographed and thereafter treated randomly either with TAF or ENG. Cure was defined as the transition of an ulcerative lesion into a non-painful chronic (M4) or into a healed (M0) stage of BDD at day 28 post-treatment. The cure rate at day 28 of M2 BDD lesions treated with TAF was 89 per cent (95 per cent CI 0.78 to 0.94), and for ENG 75 per cent (95 per cent CI 0.67 to 0.86). So the difference in cure rate was 14 per cent (95 per cent CI 0.00 to 0.27), which was statistically significant. The P value in this experiment is very close to 0.05 indicating that the effect is quite small. If a two-sided test would be used, the small significant effect, in this experiment, will disappear. Overall, the significant better curative effect of TAF on BDD M2 lesions was small, compared with ENG.
PMID
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Authors

Mayor MeshTerms
Keywords

Bacterial diseases

Case-control studies

Cattle

Clinical practice

Dairy cattle

Pain

Journal Title the veterinary record
Publication Year Start




PMID- 28465327
OWN - NLM
STAT- MEDLINE
DA  - 20170503
DCOM- 20170524
LR  - 20170524
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 180
IP  - 20
DP  - 2017 May 20
TI  - Comparing the curative efficacy of topical treatment with thiamphenicol and
      oxytetracycline on digital dermatitis lesions in dairy cattle.
PG  - 500
LID - 10.1136/vr.103758 [doi]
AB  - The efficacy of two topically applied antibiotics for the treatment of painful
      ulcerative stage of bovine digital dermatitis (BDD) lesions was compared in a
      clinical trial conducted on five dairy farms in the Netherlands during the autumn
      of 2015. A total of 109 cows with an ulcerative (M2) stage of BDD were randomly
      appointed a treatment with an antibiotic-based spray. One treatment contained
      thiamphenicol as active ingredient (TAF). The other treatment had oxytetracycline
      as active ingredient (ENG). The experimental unit for this study was the hind
      claw with the presence of an ulcerative BDD lesion. On day 0, claws with
      ulcerative BDD lesions were trimmed, cleaned, photographed and thereafter treated
      randomly either with TAF or ENG. Cure was defined as the transition of an
      ulcerative lesion into a non-painful chronic (M4) or into a healed (M0) stage of 
      BDD at day 28 post-treatment. The cure rate at day 28 of M2 BDD lesions treated
      with TAF was 89 per cent (95 per cent CI 0.78 to 0.94), and for ENG 75 per cent
      (95 per cent CI 0.67 to 0.86). So the difference in cure rate was 14 per cent (95
      per cent CI 0.00 to 0.27), which was statistically significant. The P value in
      this experiment is very close to 0.05 indicating that the effect is quite small. 
      If a two-sided test would be used, the small significant effect, in this
      experiment, will disappear. Overall, the significant better curative effect of
      TAF on BDD M2 lesions was small, compared with ENG.
CI  - British Veterinary Association.
FAU - Holzhauer, M
AU  - Holzhauer M
AD  - GD Animal Health, P.O. Box 9, Deventer 7400 AA, The Netherlands.
FAU - Ploegmakers-van Deventer, R
AU  - Ploegmakers-van Deventer R
AD  - Dechra Veterinary Products, P.O. Box 179, Bladel 5530 AD, The Netherlands.
FAU - Smits, D
AU  - Smits D
AD  - GD Animal Health, P.O. Box 9, Deventer 7400 AA, The Netherlands.
FAU - Swart, W
AU  - Swart W
AD  - GD Animal Health, P.O. Box 9, Deventer 7400 AA, The Netherlands.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170502
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 0 (Anti-Bacterial Agents)
RN  - FLQ7571NPM (Thiamphenicol)
RN  - X20I9EN955 (Oxytetracycline)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/*therapeutic use
MH  - Cattle
MH  - Cattle Diseases/*drug therapy
MH  - Digital Dermatitis/*drug therapy
MH  - Female
MH  - Oxytetracycline/administration & dosage/*therapeutic use
MH  - Thiamphenicol/administration & dosage/*therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - *Bacterial diseases
OT  - *Case-control studies
OT  - *Cattle
OT  - *Clinical practice
OT  - *Dairy cattle
OT  - *Pain
EDAT- 2017/05/04 06:00
MHDA- 2017/05/26 06:00
CRDT- 2017/05/04 06:00
PHST- 2017/03/04 [accepted]
AID - vr.103758 [pii]
AID - 10.1136/vr.103758 [doi]
PST - ppublish
SO  - Vet Rec. 2017 May 20;180(20):500. doi: 10.1136/vr.103758. Epub 2017 May 2.

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