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PMID- 28474590
DA  - 20170505
DCOM- 20170601
LR  - 20170601
IS  - 0974-7559 (Electronic)
IS  - 0019-6061 (Linking)
VI  - 54
IP  - 4
DP  - 2017 Apr 15
TI  - Epidemiology of Cryptosporidium in Pediatric Diarrheal Illnesses.
PG  - 299-309
AB  - CONTEXT: Cryptosporidium spp. is a zoonotic infection, now being recognized as a 
      significant cause of diarrhea in both immunocompetent and immunocompromised
      hosts. However, there still exist significant knowledge gaps in its estimated
      global burden, epidemiology, diagnosis and management. EVIDENCE ACQUISITION: A
      semi-systematic search was performed across PubMed to select studies on
      epidemiological burden of cryptosporidium diarrhea using the following keywords- 
      ['crytosporidiosis' OR 'cryptosporidium'] AND ['diarrhea' OR 'diarrhoea'].
      Articles were included if participants were 'Humans', belonged to pediatric (0-18
      y) age group, and were published after 1990. The results were compiled separately
      for acute and persistent diarrhea. RESULTS: Cryptosporidium spp is commonly
      detected in stools of both cases (acute/ persistent diarrhea) and asymptomatic
      controls. The prevalence is higher in children with diarrhea than non-diarrheal
      controls (1.7-35% vs 0.3-15%); varying widely across different studies. The
      positivity rate is higher in younger children (<2 years) suffering from diarrhea.
      The main symptoms associated with cryptosporidiosis include fever, vomiting and
      abdominal pain with propensity for prolonged duration of diarrhea. It predisposes
      to malnutrition, which is also a risk factor for cryptosporidiosis. The
      prevalence is higher in HIV positive patients; certain socio-demographic factors 
      play a more important role than mere geographical distribution for infection.
      CONCLUSION: The high positivity rates during both acute and persistent diarrhea
      highlights the need to suspect this infection even in immunocompetent children.
FAU - Dabas, Aashima
AU  - Dabas A
AD  - Departments of Pediatrics, $AIIMS; University College of Medical Sciences and
      Guru Teg Bahadur Hospital;and *Chacha Nehru Bal Chikitsalaya; Delhi and
      #Pediatric Biology Center, Translational Health Science and Technology Institute,
      Faridabad, Haryana; India. Correspondence to: Dr. Dheeraj Shah, Professor,
      Department of Pediatrics, University College of Medical Sciences and Guru Teg
      Bahadur Hospital, Dilshad Garden, Delhi 110 095, India. [email protected]
FAU - Shah, Dheeraj
AU  - Shah D
FAU - Bhatnagar, Shinjini
AU  - Bhatnagar S
FAU - Lodha, Rakesh
AU  - Lodha R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cryptosporidiosis/*epidemiology/parasitology
MH  - *Cryptosporidium
MH  - Diarrhea/*epidemiology/parasitology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
EDAT- 2017/05/06 06:00
MHDA- 2017/06/02 06:00
CRDT- 2017/05/06 06:00
PST - ppublish
SO  - Indian Pediatr. 2017 Apr 15;54(4):299-309.

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