Epidemiology of Cryptosporidium in Pediatric Diarrheal Illnesses.
|Abstract||Cryptosporidium spp. is a zoonotic infection, now being recognized as a significant cause of diarrhea in both immunocompetent and immunocompromised hosts. However, there still exist significant knowledge gaps in its estimated global burden, epidemiology, diagnosis and management.|
The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS).
|Journal Title||indian pediatrics|
|Publication Year Start||2017-01-01|
PMID- 28474590 OWN - NLM STAT- MEDLINE DA - 20170505 DCOM- 20170601 LR - 20170601 IS - 0974-7559 (Electronic) IS - 0019-6061 (Linking) VI - 54 IP - 4 DP - 2017 Apr 15 TI - Epidemiology of Cryptosporidium in Pediatric Diarrheal Illnesses. PG - 299-309 AB - CONTEXT: Cryptosporidium spp. is a zoonotic infection, now being recognized as a significant cause of diarrhea in both immunocompetent and immunocompromised hosts. However, there still exist significant knowledge gaps in its estimated global burden, epidemiology, diagnosis and management. EVIDENCE ACQUISITION: A semi-systematic search was performed across PubMed to select studies on epidemiological burden of cryptosporidium diarrhea using the following keywords- ['crytosporidiosis' OR 'cryptosporidium'] AND ['diarrhea' OR 'diarrhoea']. Articles were included if participants were 'Humans', belonged to pediatric (0-18 y) age group, and were published after 1990. The results were compiled separately for acute and persistent diarrhea. RESULTS: Cryptosporidium spp is commonly detected in stools of both cases (acute/ persistent diarrhea) and asymptomatic controls. The prevalence is higher in children with diarrhea than non-diarrheal controls (1.7-35% vs 0.3-15%); varying widely across different studies. The positivity rate is higher in younger children (<2 years) suffering from diarrhea. The main symptoms associated with cryptosporidiosis include fever, vomiting and abdominal pain with propensity for prolonged duration of diarrhea. It predisposes to malnutrition, which is also a risk factor for cryptosporidiosis. The prevalence is higher in HIV positive patients; certain socio-demographic factors play a more important role than mere geographical distribution for infection. CONCLUSION: The high positivity rates during both acute and persistent diarrhea highlights the need to suspect this infection even in immunocompetent children. FAU - Dabas, Aashima AU - Dabas A AD - Departments of Pediatrics, $AIIMS; University College of Medical Sciences and Guru Teg Bahadur Hospital;and *Chacha Nehru Bal Chikitsalaya; Delhi and #Pediatric Biology Center, Translational Health Science and Technology Institute, Faridabad, Haryana; India. Correspondence to: Dr. Dheeraj Shah, Professor, Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110 095, India. [email protected] FAU - Shah, Dheeraj AU - Shah D FAU - Bhatnagar, Shinjini AU - Bhatnagar S FAU - Lodha, Rakesh AU - Lodha R LA - eng PT - Journal Article PT - Review PL - India TA - Indian Pediatr JT - Indian pediatrics JID - 2985062R SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Cryptosporidiosis/*epidemiology/parasitology MH - *Cryptosporidium MH - Diarrhea/*epidemiology/parasitology MH - Humans MH - Infant MH - Infant, Newborn EDAT- 2017/05/06 06:00 MHDA- 2017/06/02 06:00 CRDT- 2017/05/06 06:00 PST - ppublish SO - Indian Pediatr. 2017 Apr 15;54(4):299-309.
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