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Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone: A case report.

Abstract Primary lymphomas of the uterine cervix are a rare disease. They are often misdiagnosed because of their rarity and because they can be easily confused with a squamous cell carcinoma of the cervix, as they are usually presented as exophytic mass with vaginal bleeding as their most common symptoms. Nevertheless, considering that both the prognosis and the treatment are completely different between them, differential diagnosis should be taken into account.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28489772
OWN - NLM
STAT- MEDLINE
DA  - 20170510
DCOM- 20170612
LR  - 20170612
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 19
DP  - 2017 May
TI  - Primary diffuse large B cell lymphoma of the uterine cervix successfully treated 
      by combined chemotherapy alone: A case report.
PG  - e6846
LID - 10.1097/MD.0000000000006846 [doi]
AB  - RATIONALE: Primary lymphomas of the uterine cervix are a rare disease. They are
      often misdiagnosed because of their rarity and because they can be easily
      confused with a squamous cell carcinoma of the cervix, as they are usually
      presented as exophytic mass with vaginal bleeding as their most common symptoms. 
      Nevertheless, considering that both the prognosis and the treatment are
      completely different between them, differential diagnosis should be taken into
      account. PATIENT CONCERNS: A case of a 51-year-old woman with a primary diffuse
      large B-cell lymphoma of the cervix is presented. DIAGNOSES: Diagnosis of this
      tumor was a challenge for pathologists and clinicians, as four biopsies were
      needed to achieve a final diagnosis. INTERVENTIONS: Patient was successfully
      treated with combined Rituximab and chemotherapy (R-CHOP) alone. OUTCOMES:
      Complete remission, confirmed through biopsy, was reached after six courses of
      chemotherapy. At 2-years follow up, patient is alive and free of disease.
      LESSONS: Considering that the prognosis and treatment of primary malignant
      lymphoma of the cervix are completely different than that of the squamous cell
      carcinoma, awareness of this disease should be considered in the differential
      diagnosis.
FAU - Cubo, Ana Maria
AU  - Cubo AM
AD  - aDepartment of Obstetrics and Gynecology bDepartment of Pathology cDepartment of 
      Radiology dDepartment of Hematology eUniversity Hospital of Salamanca (IBSAL-HUS)
      fCIBERONC, Salamanca, Spain.
FAU - Soto, Zandra Mileny
AU  - Soto ZM
FAU - Cruz, Miguel Angel
AU  - Cruz MA
FAU - Doyague, Maria Jose
AU  - Doyague MJ
FAU - Sancho, Veronica
AU  - Sancho V
FAU - Fraino, Aurymar
AU  - Fraino A
FAU - Blanco, Oscar
AU  - Blanco O
FAU - Puig, Noemi
AU  - Puig N
FAU - Alcoceba, Miguel
AU  - Alcoceba M
FAU - Gonzalez, Marcos
AU  - Gonzalez M
FAU - Sayagues, Jose Maria
AU  - Sayagues JM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antineoplastic Agents)
RN  - 4F4X42SYQ6 (Rituximab)
RN  - 5J49Q6B70F (Vincristine)
RN  - 80168379AG (Doxorubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - VB0R961HZT (Prednisone)
RN  - CHOP protocol
SB  - AIM
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Cervix Uteri/diagnostic imaging/drug effects/pathology
MH  - Cyclophosphamide/therapeutic use
MH  - Diagnosis, Differential
MH  - Doxorubicin/therapeutic use
MH  - Female
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/diagnosis/*drug therapy/pathology
MH  - Middle Aged
MH  - Prednisone/therapeutic use
MH  - Rituximab/*therapeutic use
MH  - Uterine Cervical Neoplasms/diagnosis/*drug therapy/pathology
MH  - Vincristine/therapeutic use
PMC - PMC5428606
EDAT- 2017/05/11 06:00
MHDA- 2017/06/13 06:00
CRDT- 2017/05/11 06:00
AID - 10.1097/MD.0000000000006846 [doi]
AID - 00005792-201705120-00039 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(19):e6846. doi: 10.1097/MD.0000000000006846.

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