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Is C-reactive protein a marker of obstructive sleep apnea?: A meta-analysis.

Abstract Obstructive sleep apnea (OSA) is a common disease, distinguished by recurrent episodes of upper airway obstruction during sleep, with an inflammatory component. C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) are markers of systemic inflammation and may serve as biomarkers of OSA.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28489776
OWN - NLM
STAT- MEDLINE
DA  - 20170510
DCOM- 20170612
LR  - 20170612
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 19
DP  - 2017 May
TI  - Is C-reactive protein a marker of obstructive sleep apnea?: A meta-analysis.
PG  - e6850
LID - 10.1097/MD.0000000000006850 [doi]
AB  - BACKGROUND: Obstructive sleep apnea (OSA) is a common disease, distinguished by
      recurrent episodes of upper airway obstruction during sleep, with an inflammatory
      component. C-reactive protein (CRP) and high-sensitivity C-reactive protein
      (hs-CRP) are markers of systemic inflammation and may serve as biomarkers of OSA.
      METHODS: Scientific studies published from January 1, 2006, to January 1, 2016
      were obtained via searches of PubMed, Embase, SCI, and China National Knowledge
      Internet (CNKI) using relevant terms. Studies concerning serum CRP level/ hs-CRP 
      in OSA patients were reviewed by 2 independent reviewers. Studies were included
      if they conform with our specific criteria of inclusion. Eligible studies were
      subjected to quality review, data extraction, and meta-analysis by using RevMan
      (version 5.2) and STATA (version 12.0). RESULTS: There were 15 studies that met
      inclusion criteria that included a total of 1297 subjects. Meta-analysis revealed
      that serum CRP levels in the OSA group were 1.98 mmol/L higher than those in
      control group (95% confidence interval: 1.39-2.58, P < .01). Similarly, serum
      hs-CRP levels in the OSA group were 1.57 mmol/L higher than that in the control
      group (95% confidence interval: 0.96-2.18, P < .01). Subgroup analysis showed
      greater differences between OSA patients and controls in the setting of obesity
      (body mass index)> = 30. The total weighted mean difference (WMD) between OSA and
      controls within the subgroup of subjects who had a CRP was 2.10; for hs-CRP, the 
      WMD was 2.49. Comparing OSA patients of mean apnea hypopnea index> = 15 and
      controls, the total WMD for the CRP subgroup was 2.19; for the hs-CRP subgroup,
      the WMD was 1.70. CONCLUSION: In our meta-analysis, serum CRP/hs-CRP levels were 
      discovered to be higher in OSA patients compared with control subjects. Those
      with higher body mass index and apnea hyponea index demonstrated larger
      differences in CRP/hs-CRP levels. These data are consistent with an inflammatory 
      component of OSA pathophysiology and support the role of CRP/hs-CRP as a
      biomarker in this disease.
FAU - Li, Kun
AU  - Li K
AD  - Department of Otolaryngology, Beijing An Zhen Hospital, Capital Medical
      University, Beijing, China.
FAU - Wei, Peng
AU  - Wei P
FAU - Qin, Yanwen
AU  - Qin Y
FAU - Wei, Yongxiang
AU  - Wei Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - AIM
SB  - IM
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Humans
MH  - Sleep Apnea, Obstructive/*blood
PMC - PMC5428610
EDAT- 2017/05/11 06:00
MHDA- 2017/06/13 06:00
CRDT- 2017/05/11 06:00
AID - 10.1097/MD.0000000000006850 [doi]
AID - 00005792-201705120-00043 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 May;96(19):e6850. doi: 10.1097/MD.0000000000006850.

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